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P53, P63, and P73: Internecine Relations?

  • Frank McKeon
  • Annie Yang

The discoveries of p63 and p73 as genes related to the vaunted tumor suppressor p53 launched questions that remain largely unanswered, and fuel controversy and debate. Do these homologs behave like p53? Do they also act in tumor suppression? What were their origins – spin-offs of an ancestral p53 gene, or, in fact, predecessors of this famed ‘guardian of the genome’? In vivo studies clearly reveal distinct physiological roles for p53, p63, and p73. But do these belie cooperative or antagonistic interactions within the p53 gene family?

Keywords

Proliferative Potential Epithelial Stem Cell Cortical Lamination Sterile Alpha Motif INK4A Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2007

Authors and Affiliations

  • Frank McKeon
    • 1
  • Annie Yang
    • 2
  1. 1.Department of Cell BiologyHarvard Medical SchoolBostonUSA
  2. 2.Department of Biological Chemistry and Molecular PharmacologyHarvard Medical SchoolBostonUSA

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