Advertisement

The Role Of C-Myb In Gastrointestinal Tract Development And Carcinogenesis

  • Robert G. Ramsay
  • Daniel Ciznadji
  • Gabriella Zupi
Part of the Proteins and Cell Regulation book series (PROR, volume 2)

The list of cancers in which c-Myb appears to play a role includes tumours of the upper gastrointestinal (GI) tract, colon, pancreas, melanocytes, brain and breast. This review focuses on the involvement of c-Myb in normal and neoplastic colon cells. Expression of c-myb RNA in rat, mouse and human colons is similar to, or exceeds, that observed in haemopoietic cells. In the colon c-Myb is essential for development, Bcl-2 expression and recovery from cyto-toxic damage. As in the blood system, elongation of c-myb transcripts is tightly regulated in the GI tract. Over expression of c-Myb in colon cell lines blocks differentiation, thus satisfying an important foundation for malignant transformation. c-myb expression increases during colon and oesophageal adenocarcinoma progression and in colon cancer. The level of c-myb expression in GI tract tumours has prognostic significance for patient survival.

Keywords

Adenomatous Polyposis Coli Colonic Crypt Human Colon Carcinoma Cell Line Colon Cell Line Haemopoietic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Robert G. Ramsay
    • 1
  • Daniel Ciznadji
    • 1
  • Gabriella Zupi
    • 2
  1. 1.Differentiation and Transcription LaboratoryPeter MacCallum Cancer InstituteAustralia
  2. 2.Experimental Chemotherapy LaboratoryRegina Elena Cancer InstituteItaly

Personalised recommendations