Microarrays provide a high-throughput means of identifying Myb-regulated target genes. They also provide a rich assay for measuring changes in Myb protein activity that goes far beyond the qualitative and less relevant results obtained using conventional plasmid-based reporter gene assays. Although there are several significant drawbacks to using these assays, they offer important advantages that can help dissect the complex transcriptional activities displayed by Myb proteins in various cell types.
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© 2004 Kluwer Academic Publishers
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Ness, S.A. (2004). The Microarray Big Bang. In: Frampton, J. (eds) Myb Transcription Factors: Their Role in Growth, Differentiation and Disease. Proteins and Cell Regulation, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2869-4_14
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DOI: https://doi.org/10.1007/978-1-4020-2869-4_14
Publisher Name: Springer, Dordrecht
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