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Cytokinin Regulation of the Cell Division Cycle

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Plant Hormones

Abstract

Contrary to the situation in animal systems, plant shape and size are predominantly determined by developmental programs that govern the timely initiation and outgrowth of meristems. In plants, meristematic zones almost exclusively constitute the regions of dividing cells. The role of mitotic cell division in morphogenetic and developmental processes has been the subject of intense debate, but the present view seems to acknowledge the importance of proper cell division regulation for the correct elaboration and execution of developmental programs (29)

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References

  1. Breyne P, Dreesen R, Vandepoele K, De Veylder L, Van Breusegem F, Callewaert L, Rombauts S, Raes J, Cannoot B, Engler G, Inze D, Zabeau M (2002) Transcriptome analysis during cell division in plants. Proc Natl Acad Sci U S A 99: 14825-14830

    Article  CAS  PubMed  Google Scholar 

  2. Bryant J, Francis D (2001) Plant growth regulators and the control of S-phase. In D. Francis, ed The plant cell cycle and its interfaces. Sheffield Academic Press; CRC Press, Sheffield, UK; Boca Raton, FL, pp 43-55

    Google Scholar 

  3. Brzobohaty B, Moore I, Kristoffersen P, Bako L, Campos N, Schell J, Palme K (1993) Figure 9. Tentative model for the action of zeatin at G2/M transtion in the tobacco BY-2 cell culture. Zeatin and auxin cooperate to up-regulate CDKA and cyclin B expression. The activity of the cyclin/CDK complex is enhanced by a stimulatory phosphorylation on the CDK moiety at Thr170 and is inhibited by a phosphorylation at Tyr15 (and possibly also Thr14) by Wee1-like kinase(s). Zeatin counteracts the Wee1 induced inhibition through the action of a cdc25-like phosphatase activity that removes the inhibitory phosphorylation(s) (amino acid numbering according to tobacco). Release of active cytokinin by a beta-glucosidase localized to the maize root meristem. Science 262: 1051-4

    Article  CAS  PubMed  Google Scholar 

  4. Carimi F, Zottini M, Formentin E, Terzi M, Lo Schiavo F (2003) Cytokinins: new apoptotic inducers in plants. Planta 216: 413-421

    CAS  PubMed  Google Scholar 

  5. Crowell DN, Salaz MS (1992) Inhibition of growth of cultured tobacco cells at low concentrations of lovastatin is reversed by cytokinin. Plant Physiol 100: 2090-2095

    Article  CAS  PubMed  Google Scholar 

  6. Das NK, Patau K, Skoog F (1956) Initiation and cell division by kinetin and indoleacetic acid in excised tobacco pith tissue. Physiol Plant 9: 640-651

    Article  CAS  Google Scholar 

  7. de O. Manes C, Van Montagu M, Prinsen E, Goethals K, Holsters M (2001) De novo cortical cell division triggered by the phytopathogen Rhodococcus fascians in tobacco. Mol Plant Microbe Interact 14: 189-195

    Article  Google Scholar 

  8. Dewitte W, Chiappetta A, Azmi A, Witters E, Strnad M, Rembur J, Noin M, Chriqui D, Van Onckelen H (1999) Dynamics of cytokinins in apical shoot meristems of a dayneutral tobacco during floral transition and flower formation. Plant Physiol 119: 111-122

    Article  CAS  PubMed  Google Scholar 

  9. Dewitte W, Murray JAH (2003) The plant cell cycle. Annu Rev Plant Biol 54: 235-264

    Article  CAS  PubMed  Google Scholar 

  10. Dewitte W, Van Onckelen H (2001) Probing the distribution of plant hormones by immunocytochemistry. Plant Growth Regul 33: 67-74

    Article  CAS  Google Scholar 

  11. Dobrev P, Motyka V, Gaudinova A, Malbeck J, Travnickova A, Kaminek M, Vankova R (2002) Transient accumulation of cis- and trans-zeatin type cytokinins and its relation to cytokinin oxidase activity during cell cycle of synchronized tobacco BY-2 cells. Plant Physiol Biochem 40: 333-337

    Article  CAS  Google Scholar 

  12. Estruch JJ, Granell A, Hansen G, Prinsen E, Redig P, Van Onckelen H, Schwarz- Sommer Z, Sommer H, Spena A (1993) Floral development and expression of floral homeotic genes are influenced by cytokinins. Plant J 4: 379-384

    Article  CAS  PubMed  Google Scholar 

  13. Francis D, Sorrell DA (2001) The interface between the cell cycle and plant growth regulators: a mini review. Plant Growth Regul 33: 1-12

    Article  CAS  Google Scholar 

  14. Frank M, Guivarc'h A, Krupkova E, Lorenz-Meyer I, Chriqui D, Schmulling T (2002) TUMOROUS SHOOT DEVELOPMENT (TSD) genes are required for co-ordinated plant shoot development. Plant J 29: 73-85

    Article  CAS  PubMed  Google Scholar 

  15. Glab N, Labidi B, Qin LX, Trehin C, Bergounioux C, Meijer L (1994) Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions. FEBS Lett 353: 207-211

    Article  CAS  PubMed  Google Scholar 

  16. Helliwell CA, Chin-Atkins AN, Wilson IW, Chapple R, Dennis ES, Chaudhury A (2001) The Arabidopsis AMP1 gene encodes a putative glutamate carboxypeptidase. Plant Cell 13: 2115-2125

    Article  CAS  PubMed  Google Scholar 

  17. Hemerly AS, Ferreira P, de Almeida Engler J, Van Montagu M, Engler G, Inze D (1993) cdc2a expression in Arabidopsis is linked with competence for cell division. Plant Cell 5: 1711-1723

    Article  CAS  PubMed  Google Scholar 

  18. Hemmerlin A, Bach TJ (1998) Effects of mevinolin on cell cycle progression and viability of tobacco BY-2 cells. Plant J 14: 65-74

    Article  CAS  PubMed  Google Scholar 

  19. Houssa C, Bernier G, Pieltain A, Kinet JM, Jacqmard A (1994) Activation of latent DNA-replication origins - a universal effect of cytokinins. Planta 193: 247-250

    Article  CAS  Google Scholar 

  20. Inoue T, Higuchi M, Hashimoto Y, Seki M, Kobayashi M, Kato T, Tabata S, Shinozaki K, Kakimoto T (2001) Identification of CRE1 as a cytokinin receptor from Arabidopsis. Nature 409: 1060-1063

    Article  CAS  PubMed  Google Scholar 

  21. Ivanova M, Rost TL (1997) Cytokinins and the plant cell cycle: Problems and pitfalls of proving their function. In JA Bryant, D Chiatante, eds Plant cell proliferation and its regulation in growth and development. John Wiley & Sons, Chichester, pp 45-57

    Google Scholar 

  22. John PCL (1998) Cytokinin stimulation of cell division: essential signal transduction is via Cdc25 phosphatase. J Exp Bot 49 (suppl.): 91

    Google Scholar 

  23. Laureys F, Dewitte W, Witters E, Van Montagu M, Inze D, Van Onckelen H (1998) Zeatin is indispensable for the G2-M transition in tobacco BY-2 cells. FEBS Lett 426: 29-32

    Article  CAS  PubMed  Google Scholar 

  24. Laureys F, Smets R, Lenjou M, Van Bockstaele D, Inze D, Van Onckelen H (1999) A low content in zeatin type cytokinins is not restrictive for the occurrence of G1/S transition in tobacco BY-2 cells. FEBS Lett 460: 123-128

    Article  CAS  PubMed  Google Scholar 

  25. 25. Letham DS (1963) Zeatin, a factor inducing cell division from Zea mays. Life Sci 8:

    Google Scholar 

  26. Mader JC, Hanke DE (1996) Immunocytochemical study of cell cycle control by cytokinin in cultured soybean cells. J Plant Growth Regul 15: 95-102

    Article  CAS  Google Scholar 

  27. Magyar Z, Atanassova A, De Veylder L, Rombauts S, Inze D (2000) Characterization of two distinct DP-related genes from Arabidopsis thaliana. FEBS Lett 486: 79-87

    Article  CAS  PubMed  Google Scholar 

  28. Mähönen AP, Bonke M, Kauppinen L, Riikonen M, Benfey PN, Helariutta Y (2000) A novel two-component hybrid molecule regulates vascular morphogenesis of the Arabidopsis root. Genes Dev 14: 2938-2943

    Article  PubMed  Google Scholar 

  29. Meijer M, Murray JA (2001) Cell cycle controls and the development of plant form. Curr Opin Plant Biol 4: 44-49

    Article  CAS  PubMed  Google Scholar 

  30. Menges M, Hennig L, Gruissem W, Murray JA (2002) Cell cycle-regulated gene expression in Arabidopsis. J Biol Chem 277: 41987-42002

    Article  CAS  PubMed  Google Scholar 

  31. Menges M, Murray JA (2002) Synchronous Arabidopsis suspension cultures for analysis of cell-cycle gene activity. Plant J 30: 203-212

    Article  CAS  PubMed  Google Scholar 

  32. Miller CO, Skoog F, von Saltza MH, Strong FM (1955) Kinetin, a cell division factor from deoxyribonucleic acid. J Amer Chem Soc 77: 1329-1334

    Google Scholar 

  33. Mironov V, De Veylder L, Van Montagu M, Inze D (1999) Cyclin-dependent kinases and cell division in plants- the nexus. Plant Cell 11: 509-522

    Article  CAS  PubMed  Google Scholar 

  34. Mlejnek P, Procházka S (2002) Activation of caspase-like proteases and induction of apoptosis by isopentenyladenosine in tobacco BY-2 cells. Planta 215: 158-166

    Article  CAS  PubMed  Google Scholar 

  35. Murray JAH, Doonan J, Riou-Khamlichi C, Meijer M, Oakenfull EA (2001) G1 cyclins, cytokinins and the regulation of the G1/S transition. In D. Francis, ed The plant cell cycle and its interfaces. Sheffield Academic Press; CRC Press, Sheffield, UK; Boca Raton, FL, pp 19-41

    Google Scholar 

  36. Nagata T, Kumagai F (1999) Plant cell biology through the window of the highly synchronized tobacco BY-2 cell line. Methods Cell Sci 21: 123-127

    Article  CAS  PubMed  Google Scholar 

  37. Nagata T, Nemoto Y, Hasezawa S (1992) Tobacco BY-2 cell line as the 'HeLa' cell in the cell biology of higher plants. Int Rev Cytol 132: 1-30

    Article  CAS  Google Scholar 

  38. Nakagami H, Kawamura K, Sugisaka K, Sekine M, Shinmyo A (2002) Phosphorylation of retinoblastoma-related protein by the cyclin D/cyclin-dependent kinase complex is activated at the G1/S-phase transition in tobacco. Plant Cell 14: 1847-1857

    Article  CAS  PubMed  Google Scholar 

  39. Nishinari N, Syono K (1986) Induction of cell division synchrony and variation of cytokinin contents through the cell cycle in tobacco cultured cells. Plant Cell Physiol 27: 147-153

    CAS  Google Scholar 

  40. Papon N, Clastre M, Gantet P, Rideau M, Chenieux JC, Creche J (2003) Inhibition of the plant cytokinin transduction pathway by bacterial histidine kinase inhibitors in Catharanthus roseus cell cultures. FEBS Lett 537: 101-105

    Article  CAS  PubMed  Google Scholar 

  41. Planchais S, Glab N, Inze D, Bergounioux C (2000) Chemical inhibitors: a tool for plant cell cycle studies. FEBS Lett 476: 78-83

    Article  CAS  PubMed  Google Scholar 

  42. Planchais S, Glab N, Trehin C, Perennes C, Bureau JM, Meijer L, Bergounioux C (1997) Roscovitine, a novel cyclin-dependent kinase inhibitor, characterizes restriction point and G2/M transition in tobacco BY-2 cell suspension. Plant J 12: 191-202

    Article  CAS  PubMed  Google Scholar 

  43. Prinsen E, Van Dongen W, Esmans EL, Van Onckelen HA (1998) Micro and capillary liquid chromatography tandem mass spectrometry: a new dimension in phytohormone research. J Chromatogr A 826: 25-37

    Article  CAS  Google Scholar 

  44. Redig P, Schmulling T, Van Onckelen H (1996) Analysis of cytokinin metabolism in ipt transgenic tobacco by Liquid Chromatography-Tandem Mass Spectrometry. Plant Physiol 112: 141-148

    CAS  PubMed  Google Scholar 

  45. Redig P, Shaul O, Inze D, Van Montagu M, Van Onckelen H (1996) Levels of endogenous cytokinins, indole-3-acetic acid and abscisic acid during the cell cycle of synchronized tobacco BY-2 cells. FEBS Lett 391: 175-180

    Article  CAS  PubMed  Google Scholar 

  46. Riou-Khamlichi C, Huntley R, Jacqmard A, Murray JAH (1999) Cytokinin activation of Arabidopsis cell division through a D-type cyclin. Science 283: 1541-1544

    Article  CAS  PubMed  Google Scholar 

  47. Sakai H, Honma T, Aoyama T, Sato S, Kato T, Tabata S, Oka A (2001) ARR1, a transcription factor for genes immediately responsive to cytokinins. Science 294: 1519-1521

    Article  CAS  PubMed  Google Scholar 

  48. Schulze-Gahmen U, Brandsen J, Jones HD, Morgan DO, Meijer L, Vesely J, Kim SH (1995) Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine. Proteins 22: 378-391

    Article  CAS  PubMed  Google Scholar 

  49. Skoog F, Miller CO (1957) Chemical regulation of growth and organ formation in plant tissues cultured in vitro. Symp Soc Exp Biol 11: 118-131

    Google Scholar 

  50. Smalle J, Kurepa J, Yang P, Babiychuk E, Kushnir S, Durski A, Vierstra RD (2002) Cytokinin growth responses in Arabidopsis involve the 26S proteasome subunit RPN12. Plant Cell 14: 17-32

    Article  CAS  PubMed  Google Scholar 

  51. Sorrell DA, Combettes B, Chaubet-Gigot N, Gigot C, Murray JA (1999) Distinct cyclin D genes show mitotic accumulation or constant levels of transcripts in tobacco Bright Yellow-2 cells. Plant Physiol 119: 343-352

    Article  CAS  PubMed  Google Scholar 

  52. Sorrell DA, Marchbank A, McMahon K, Dickinson JR, Rogers HJ, Francis D (2002) A WEE1 homologue from Arabidopsis thaliana. Planta 215: 518-522

    Article  CAS  PubMed  Google Scholar 

  53. Stals H, Inze D (2001) When plant cells decide to divide. Trends Plant Sci 6: 359-364

    Article  CAS  PubMed  Google Scholar 

  54. Suzuki T, Miwa K, Ishikawa K, Yamada H, Aiba H, Mizuno T (2001) The Arabidopsis sensor His-kinase, AHK4, can respond to cytokinins. Plant Cell Physiol 42: 107-113

    Article  CAS  PubMed  Google Scholar 

  55. Temmerman W, Ritsema T, Simon-Mateo C, Van Montagu M, Mironov V, Inze D, Goethals K, Holsters M (2001) The fas locus of the phytopathogen Rhodococcus fascians affects mitosis of tobacco BY-2 cells. FEBS Lett 492: 127-132

    Article  CAS  PubMed  Google Scholar 

  56. The Arabidopsis Genome Initiative (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408: 796-815

    Article  Google Scholar 

  57. Vermeulen K, Strnad M, Havlicek L, Van Onckelen H, Lenjou M, Nijs G, Van Bockstaele DR, Berneman ZN (2002) Plant cytokinin analogues with inhibitory activity on cyclin-dependent kinases exert their antiproliferative effect through induction of apoptosis initiated by the mitochondrial pathway: determination by a multiparametric flow cytometric analysis. Exp Hematol 30: 1107-1114

    Article  CAS  PubMed  Google Scholar 

  58. Vittorioso P, Cowling R, Faure JD, Caboche M, Bellini C (1998) Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506- binding protein-like protein, has a dramatic effect on plant development. Mol Cell Biol 18: 3034-43

    CAS  PubMed  Google Scholar 

  59. Witters E, Vanhoutte K, Dewitte W, Machackova I, Benkova E, Van Dongen W, Esmans EL, Van Onckelen HA (1999) Analysis of cyclic nucleotides and cytokinins in minute plant samples using phase-system switching capillary electrospray-liquid chromatography-tandem mass spectrometry. Phytochem Anal 10: 143-151

    Article  CAS  Google Scholar 

  60. Yamada H, Suzuki T, Terada K, Takei K, Ishikawa K, Miwa K, Yamashino T, Mizuno T (2001) The Arabidopsis AHK4 histidine kinase is a cytokinin-binding receptor that transduces cytokinin signals across the membrane. Plant Cell Physiol 42: 1017-1023

    Article  CAS  PubMed  Google Scholar 

  61. Yang SW, Jin E, Chung IK, Kim WT (2002) Cell cycle-dependent regulation of telomerase activity by auxin, abscisic acid and protein phosphorylation in tobacco BY-2 suspension culture cells. Plant J 29: 617-626

    Article  CAS  PubMed  Google Scholar 

  62. Zhang K, Letham DS, John PC (1996) Cytokinin controls the cell cycle at mitosis by stimulating the tyrosine dephosphorylation and activation of p34cdc2-like H1 histone kinase. Planta 200: 2-12

    Article  CAS  PubMed  Google Scholar 

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Roef, L., Van Onckelen, H. (2010). Cytokinin Regulation of the Cell Division Cycle. In: Davies, P.J. (eds) Plant Hormones. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2686-7_12

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