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Technology for Combating WMD Terrorism pp 111–117Cite as

Four-Week-Long Tabun Low-Level Exposure in Rats

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Part of the book series: NATO Science Series ((NAII,volume 174))

Abstract

Prolonged administration of sublethal doses of organophosphorus cholinesterase inhibitors results in adaptation to their toxicity. In order to investigate this phenomenon, we exposed rats to 0.2, 0.3 or 0.4 LD50 of tabun sc daily during four weeks. AChE activities in erythrocytes, diaphragm and brain were inhibited dose-dependently after days 7 and 14 of the study and started to recover thereafter, except after 0.4 LD50. Tabun 0.3 LD50 decreased body weight gain, food and water consumption during the first two weeks of the study. Spontaneous locomotor activity was significantly increased in the same interval and decreased thereafter. These findings support the assumption that both the biochemical and receptor mechanisms are responsible for the occurrence of tolerance to tabun in rats.

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References

  1. Du Bois, K.P. (1963) Toxicological evaluation of the anticholinesterase agents. In: Koelle, G.B. (editor) Cholinesterases and anticholinesterase agents, Springer-Verlag, Berlin, pp. 833–859.

    Google Scholar 

  2. Du Bois, K.B. et al. (1949) J. Pharmacol. Exp. Ther. 95, 79–91.

    Google Scholar 

  3. Du Bois, K.B. and Coon, J.M. (1950) J Pharmacol. Exp. Ther. 99, 376–393.

    Google Scholar 

  4. Du Bois, K.B. et al. (1953) A.M.A. Arch. Industr. Hyg. 8, 350–358.

    Google Scholar 

  5. Du Bois, K.B. and Cotter, G.J. (1955) A.M.A. Arch. Industr. Hlth 11, 53–60.

    Google Scholar 

  6. Barnes, J.M. and Denz, F.A. (1954) Br. J. Industr. Med. 11, 11–19.

    CAS  Google Scholar 

  7. Bombinski, T.J. and Du Bois, K.P. (1958) A.M.A. Arch. Industr. Hlth 17, 192–199.

    CAS  Google Scholar 

  8. Russell, R.W. et al. (1975) J. Pharmacol. Exp. Ther. 192, 73–85.

    PubMed  CAS  Google Scholar 

  9. Dulaney, M.D. Jr. et al. (1985) Acta Pharmacol. Toxicol. 57, 234–241.

    Article  CAS  Google Scholar 

  10. Bajgar, J. (1992) Br. J. Industr. Med. 49, 648–653.

    CAS  Google Scholar 

  11. Husain, K. et al. (1993) J. Appl. Toxicol. 13, 43–145.

    Article  Google Scholar 

  12. Haley, W. and Kurt, T.L. (1997) J. Am. Med. Assoc. 277, 231–237.

    Article  CAS  Google Scholar 

  13. Brown, M.A. and Kelley, A.B. (1998) 18, 393–408.

    Google Scholar 

  14. Ray, D.E. (1998) Toxicol. Lett. 102–103, 527–533.

    Article  Google Scholar 

  15. Kassa, J. et al. (2001) Pharmacol. Toxicol. 88, 209–212.

    Article  PubMed  CAS  Google Scholar 

  16. Stojiljkovic, M.P. (1997) Prophylaxis of poisoning with soman, Andrejevic Foundation, Belgrade.

    Google Scholar 

  17. Ellman, G.L. et al. (1961) Biochem. Pharmacol. 7, 88–94.

    Article  PubMed  CAS  Google Scholar 

  18. Glow, P.H. et al. (1966) J. Comp. Physiol. Psychol. 61, 295–299.

    Article  PubMed  CAS  Google Scholar 

  19. D’Mello, G.D. (1992) Neurobehavioural toxicology of anticholinesterases. In: Ballantyne, B. et al. (editors). Clinical and experimental toxicology of organophosphates and carbamates, Butterworth-Heinemann, Oxford, pp. 61–74.

    Google Scholar 

  20. Sterri, S.H. et al. (1980) Acta Pharmacol. Toxicol. 46, 1–7.

    Article  CAS  Google Scholar 

  21. Sterri, S.H. et al. (1981) Acta Pharmacol. Toxicol. 49, 8–13.

    Article  CAS  Google Scholar 

  22. Sterri, S.H. et al. (1982) Acta Pharmacol. Toxicol. 50, 326–331.

    Article  CAS  Google Scholar 

  23. Koehn, G.L. and Karczmar, A.G. (1978) Prog. Neuro-Psychopharmacol. 2, 169–177.

    Article  CAS  Google Scholar 

  24. Romano, J.A. Jr. and Landauer, M.R. (1986) Fundam. Appl. Toxicol. 6, 62–68.

    Article  CAS  Google Scholar 

  25. D’Mello, G.D. and Duffy, E.A.M. (1985) Fundam. Appl. Toxicol. 5, S169 - S174.

    Article  PubMed  Google Scholar 

  26. Landauer, M.R. and Romano, J.A. (1984) Neurobehav. Toxicol. Teratol. 6, 239–243.

    PubMed  CAS  Google Scholar 

  27. Raffaele K. et al. (1987) Pharmacol. Biochem. Behav. 27, 407–412.

    Article  CAS  Google Scholar 

  28. Romano, J.A. et al. (1985) Proc. 5th Annu. Chem. Def. Biosci. Rev., Columbia, USA, 29–31 May 1985.

    Google Scholar 

  29. Rondeau, D.B. et al. (1981) Neurobehav. Toxicol. Teratol. 3, 313–319.

    Google Scholar 

  30. Stojiljkovic, M.P. et al. (2001) Proc. 7th Int. Symp. Protect. Chem. Biol. Warfare Agents, Stockholm, Sweden, 15–19 June 2001.

    Google Scholar 

  31. Stevens, J.T. et al. (1972) J. Pharmacol. Exp. Ther. 181, 576–583.

    CAS  Google Scholar 

  32. Sivam, S.P. et al. (1983) J. Neurochem. 40, 1414–1422.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. National Poison Control Centre & Institute for Scientific Information, Military Medical Academy, Crnotravska 17, Serbia

    Milos P. Stojiljkovic, Zoran A. Milovanovic, Vesna Kilibarda & Dubravko Bokonjic

  2. Institute of Toxicological Chemistry, Faculty of Pharmacy, Vojvode Stepe 450, YU-11000, Belgrade, Federal Republic of Yugoslavia

    Danka Stefanovic & Biljana Antonijevic

Authors
  1. Milos P. Stojiljkovic
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  2. Zoran A. Milovanovic
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  3. Vesna Kilibarda
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  4. Dubravko Bokonjic
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  5. Danka Stefanovic
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  6. Biljana Antonijevic
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Editor information

Editors and Affiliations

  1. US Army Edgewood Chemical Biological Center, 5183 Blackhawk Road, 21010-5424, Aberdeen Proving Ground, MD, USA

    Peter J. Stopa

  2. Ministry of Defense, Zagreb, Republic of Croatia

    Zvonko Orahovec

  3. Laboratory for NBC Protection NBC Training Center, LTC Zvonko Orahovec, Ilica 256b, HR-10 000, Zagreb, Croatia

    Zvonko Orahovec

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© 2004 Springer Science+Business Media Dordrecht

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Stojiljkovic, M.P., Milovanovic, Z.A., Kilibarda, V., Bokonjic, D., Stefanovic, D., Antonijevic, B. (2004). Four-Week-Long Tabun Low-Level Exposure in Rats. In: Stopa, P.J., Orahovec, Z. (eds) Technology for Combating WMD Terrorism. NATO Science Series, vol 174. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2683-6_13

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  • DOI: https://doi.org/10.1007/978-1-4020-2683-6_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-2682-9

  • Online ISBN: 978-1-4020-2683-6

  • eBook Packages: Springer Book Archive

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