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Beta-2-microglobulin amyloidosis

  • Michel Jadoul
  • Charles van Ypersele de Strihou

Abstract

The first report of the carpal tunnel syndrome (CTS) in hemodialysis (HD) patients was published in 1975 (1). Five years later Assenat et al. reported that amyloid was present in tissue harvested during CTS surgery in HD patients (2). In 1985 Gejyo et al. identified β2-microglobulin (β2m) as the main constituent of “dialysis-related” amyloid deposits (3), a complication hence named β2-microglobulin amyloidosis, now abbreviated as Aβ2m in accordance with WHO guidelines on the nomenclature of amyloidosis (4). The subsequent 10–12 years were mainly devoted to the elucidation of the determinants of β2m metabolism in renal failure and dialysis, as well as to the careful delineation of the clinical picture, epidemiology, pathology and diagnosis of Aβ2m (5— 10). The beneficial influence of renal transplantation on Aβ2m was also reported (11,12). Over the past 5— 7 years emphasis has been put on more fundamental aspects of the amyloidogenic process (13–15).

Keywords

Amyloid Deposit Amyloid Fibril Bone Cyst Nephrol Dial Transplant Human Synovial Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Michel Jadoul
  • Charles van Ypersele de Strihou

There are no affiliations available

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