Abstract
Aside from the organic uremic toxins it has become evident during recent decades that inorganic solutes may also be responsible for some of the symptomatology of the uremic state. Hence, interest in trace element accumulation/deficiency and the potential toxic consequences of disturbed concentrations of these substances has grown rapidly (1).
Keywords
- Trace Metal
- Chronic Renal Failure
- Dialysis Patient
- Hemodialysis Patient
- Continuous Ambulatory Peritoneal Dialysis
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References
Alfrey AC. Trace elements and regular dialysis. In: Maher JF, editor. Replacement of Renal Function by Dialysis. Dordrecht: Kluwer, 1989:996–1003.
Seiler HG, Sigel A, Sigel H. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994.
D’Haese PC, De Broe ME. Adequacy of dialysis: trace elements in dialysis fluids. Nephrol Dial Transplant. 1996; 11(Suppl. 2):92–7.
Coburn JW, Alfrey AC. Conference on Aluminum-related Disease. New York: Springer-Verlag, 1986.
De Broe ME, Coburn JW. Aluminum and Renal Failure. Dordrecht: Kluwer, 1989.
Van Landeghem GF, D’Haese PC, Lamberts LV, De Broe ME. A quantitative HPIEC-ETAAS hybrid technique for studying the protein binding and speciation of aluminum. Anal Chem. 1994;66:216–22.
Das AK, Chakraborty R, Cervera ML, de la Guardia M. Metal speciation in biological fluids — a review. Mikrochim Acta. 1996;122:209–46.
Van Landeghem GF, De Broe ME, D’Haese PC. Al and Si: their speciation, distribution, and toxicity — a critical review. Clin Biochem. 1998;31,385–97.
Nordio M, Andriani M, Gerotto M, Marchini P, Zambenedetti P, Zatta P. Serum concentration of trace elements during different stages of chronic renal failure. Ital J Miner Elect Metab. 1988;12:81–6.
Altmann P, Butter KC, Plowman D, Chaput de Saintonge DM, Cunningham J, Marsh FP. Residual renal function in hemodialysis patients may protect against hyperaluminemia. Kidney Int. 1989;32:710–13.
Smythe WR, Alfrey AC, Craswell PW et al. Trace metal abnormalities in chronic uremia. Ann Intern Med. 1982;96:302–10.
Blumsohn A, Morris B, Eastell R. Stable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. Clin Sci. 1994;87:363–8.
Mahaffey KR. Biotoxicity of lead: influence of various factors. Fed Proc. 1983;42:1730–4.
Barton JC, Conrad ME, Harrison L, Nuby S. Effects of calcium on the absorption and retention of lead. J Lab Clin Med. 1978;91:366–76.
Ittel TH. Determinants of gastrointestinal absorption and distribution of aluminium in health and uremia. Nephrol Dial Transplant. 1993;8(Suppl. 1):17–24.
van der Voet GB, van Ginkel MF, de Wolff FA. Intestinal absorption of aluminum in rats: stimulation by citric acid and inhibition by dinitrophenol. Toxicol Appl Pharmacol. 1989;99:90–7.
Froment DPH, Molitoris BA, Buddington B, Miller N, Alfrey AC. Site and mechanism of enhanced gastrointestinal absorption of aluminum citrate. Kidney Int. 1989;36:978–84.
Ittel TH, Kinzel S, Ortmanns A, Sieberth H-G. Effect of iron status on the intestinal absorption of aluminum: a reappraisal. Kidney Int. 1996;50:1879–88.
Van Landeghem GF, D’Haese PC, Lamberts LV, De Broe ME. Competition of iron and aluminum for transferrin: the molecular basis for aluminum deposition in iron-overloaded dialysis patients? Exp Nephrol. 1997;5:239–45.
Canavese C, Pacitti M, Salomone M et al. Strontium overload in uremic patients on regular dialytic treatment. Trans Am Soc Artif Intern Organs. 1986;32:120–2.
Hoffbrand AV, Refaie F, Davis B et al. Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients. Blood. 1998;91:295–300.
Sunder-Plassmann G, Hörl WH. Erythropoietin and iron. Clin Nephrol. 1997;47:141–57.
Van Landeghem GF, D’Haese PC, Lamberts LV et al. Low serum aluminum values in dialysis patients with increased bone aluminum levels. Clin Nephrol. 1998;50:69–76.
Hosokawa S, Yoshida O. Effects of erythropoietin on trace elements in patients with chronic renal failure undergoing hemodialysis. Nephron. 1993;65:414–7.
Gammelgaard B, Sandberg E. Aluminium and nickel in human albumin solutions. J Trace Elem Electrolytes Health Dis. 1989;3:39–42.
D’Haese PC, Lamberts LV, Liang L, Boone LP, Van Waeleghem, De Broe ME. Contribution of parenteral and dialysate solutions to the aluminum accumulation in dialysis patients. Blood Purif. 1990;8:359–62.
Hawkins NM, Coffey S, Lawson MS, Delves HT. Potential aluminum toxicity in infants fed special infant formula. J Pediatr Gastroenterol Nutr. 1994;19:377–81.
Simoes J, Barata JD D’Haese PC, de Broe ME. Celanarrivequaux autres. Nephrol Dial Transplant. 1994;9: 67–8.
Barata JD, D’Haese PC, Pires C, Lamberts LV, Simoes J, De Broe ME. Low-dose (5 mg/kg) desferrioxamine treatment in acutely aluminum-intoxicated hemodialysis patients using two drug administration schedules. Nephrol Dial Transplant. 1996;11:125–32.
D’Haese PC, Shaheen FA, Huraib SO et al. Increased silicon levels in dialysis patients due to the high silicon content in the drinking water, inadequate water treatment procedures, and concentrate contamination: a multicentre study. Nephrol Dial Transplant. 1995;10:1838–44.
Caramelo CA, Cannata JB, Rodeles MR. Mechanisms of aluminum-induced microcytosis: lessons from accidental aluminum intoxication. Kidney Int. 1995;47:164–8.
Milacic, Benedik M, Knezevic S. Adsorption-desorption processes of aluminium, zinc and copper on plastic tubing in hacmodialysis montors. Clin Chim Acta. 1997; 265:169–244.
Leong As-Y, Disney APS, Gove DW. Spallation and migration of silicone from blood-pump tubing in patients on hemodialysis. N Engl J Med. 1982;306:135–40.
Webster JD, Parker TF, Alfrey AC et al. Acute nickel intoxication by dialysis. Ann Intern Med. 1980;82:631–4.
Gallery EDM, Blomfeld D, Dixon SRA. Acute zinc toxicity in hemodialysis. Br Med J. 1972;4:331–3.
Shapiro WB, Schilb TP, Waltrous CL, Levy SR, Porush JG. Aluminum leakage from REDY sorbent cartridge. Kidney Int. 1983;23:536–9.
Parkinson JS, Ward MK, Kerr DNS. Dialysis encephalopathy, bone disease and anaemia: the aluminum intoxication syndrome during regular hemodialysis. J Clin Pathol. 1981;34:1285–94.
Klein WJ, Metz EN, Price AR. Acute copper intoxication. Arch Intern Med. 1972;129:578.
Vorbeck-Meister I, Sommer R, Vorbeck F, Hör WH. Quality of water used for haemodialysis: bacteriological and chemical parameters. Nephrol Dial Transplant. 1999; 14:666–75.
Schrooten I, Elseviers MM, Lamberts LV, De Broe ME, D’Haese PC. Increased serum strontium levels in dialysis patients. An epidemiological survey. Kidney Int. 1999;56:1888–92.
Padovese P, Gallieni M, Brancaccio D et al. Trace elements in dialysis fluids and assessment of the exposure of patients on regular hemodialysis, hemofiltration and continuous ambulatory peritoneal dialysis. Nephron. 1992;61:442–8.
Chaleil D, Simon P, Tessier B, Cartier F, Allain P. Blood plasma fluoride in haemodialysed patients. Clin Chim Acta. 1986;156:105–8.
Mauras Y, Ang KS, Simon P, Tessier B, Cartier F, Allain P. Increase in blood plasma levels of boron and strontium in hemodialyzed patients. Clin Chim Acta. 1986;156:315–20.
Henderson I, Leung A, Halls D, Fell G, Dobbie J, Kennedy AC. Hyperchromiumaemia in chronic dialysis patients. Proc EDTA-ERA. 1985;22:270–5.
Saint-Georges MD, Bonnefont DJ, Bourely BA et al. Correction of selenium deficiency in hemodialyzed patients. Kidney Int. 1989;36(Suppl. 27):S274–7.
Wallaeys B, Cornelis R, Mees L, Lameire N. Trace elements in serum, packed cells, and dialysate of CAPD patients. Kidney Int. 1986;30:599–604.
Vanrenterghem D, Cornelis R, Vanholder R. Behaviour of 12 trace elements in serum of uremic patients on hemodiafiltration. J Trace Elem Electrolytes Health Dis. 1992;6: 169–74.
de Fransisco AL, Botella J, Escallada R et al. Haemodiafiltration with sorbent-regenerated ultrafiltrate as replacement fluid: a multicenter study. Nephrol Dial Transplant. 1997;12:528–34.
Hdez-Jaras J, Galán A, Sanchez P. Accidental aluminum intoxication in patients undergoing acetate-free biofiltration. Nephron. 1998;78:274–7.
Surian M, Bonforte G, Scanziani R et al. Trace elements and micropollutant anions in the dialysis and reinfusion fluid prepared on-line for haemodiafiltration. Nephrol Dial Transplant. 1998;13(Suppl. 5):24–8.
Bonforte G, Surian M, Dozio B et al. Plasma or whole blood concentrations of trace elements in patients treated by haemodiafiltration with on-line prepared substitution fluid. Nephrol Dial Transplant. 1998;13(Suppl. 5):29–33.
Geldmacher-von Mallinckrodt M and Meissner D. General aspects of the role of metals in clinical chemistry. In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1984:13–29.
Luckey TD, Venugopal B. Metal Toxicity in Mammals Physiologic and Chemical Basis for Metal Toxicity. New York: Plenum, 1977.
Smans, KA, D’Haese PC, Van Landeghem GF et al. Transferrin-mediated uptake of aluminium by human parathyroid cells results in reduced parathyroid hormone secretion. Nephrol Dial Transplant. 2000;15:1328–36.
Van Landeghem GF, D’Haese PC, Lamberts LV, Barata JD, De Broe ME. Aluminum speciation in cerebrospinal fluid of acutely intoxicated patients before and after desferrioxamine administration: a step in the understanding of the element’s neurotoxicity. Nephrol Dial Transplant. 1997;12:1692–8.
Lyle WH. Chronic dialysis and copper poisoning. N Engl J Med. 1967;276:1209–10.
Mitchell G, Cirksena W, Samara G, Wax C. Acute fluoride intoxication in hemodialysis patients. J Am Soc Nephrol. 1980;13:47 (abstract).
D’Haese PC, Clement JP, Elseviers MM, Lamberts LV, Van de Vyver FL, De Broe ME. Value of serum aluminum monitoring in dialysis patients: a multicenter study. Nephrol Dial Transplant. 1990;5:45–53.
D’Haese PC, Couttenye M-M, De Broe ME. Diagnosis and treatment of aluminium bone disease. Nephrol Dial Transplant. 1996;11(Suppl.):74–7.
De Broe ME, Drüeke TB, Ritz E. Consensus Conference: Diagnosis and treatment of aluminum overload in end-stage renal failure patients. Nephrol Dial Transplant. 1993; 8(Suppl. 1):1–4
Burwen DR, Olsen SM, Bland LA, Arduino MJ, Reid MH, Jarvis WR. Epidemic aluminum intoxication in haemodialysis patients traced to use an aluminum pump. Kidney Int. 1995;48:469–74
Berend V, van der Voet G, Boer WH. Acute aluminum encephalopathy in a dialysis center caused by a cement mortar water distribution pipe. Kidney Int. 2001;59:746–53
Smans KA, Van Landeghem GF, D’Haese PC, Couttenye MM, De Broe ME. Is there a link between erythropoietin therapy and adynamic bone disease? Nephrol Dial Transplant. 1996;11:1248–9
Kasai K, Hori MT, Goodman WG. Transferrin enhances the antiproliferative effect of aluminum on osteoblastlike cells. Am J Physiol Endocrinol Metab. 1991;260: E537–43
Gitelman HJ, Alderman F, Perry SJ. Renal handling of silicon in normals and in patients with renal insufficiency. Kidney Int. 1992;42:957–9
Dobbie JW, Smith MJB. Urinary and serum silicon in normal and uremic individuals. Ciba Found Symp. 1986; 121:194–213
Gitelman HJ, Alderman FR, Perry SJ. Silicon accumulation in dialysis patients. Am J Kidney Dis. 1992;19,140–3
Parry R, Plowman D, Delves HT et al. Silicon and aluminum interactions in haemodialysis patients. Nephrol Dial Transplant. 1998;13:1759–62
Edwardson JA, Moore PB, Ferrier IN et al. Effect of silicon on gastrointestinal absorption of aluminium. Lancet. 1993;342:211–12
Shainkin-Kestenbaum R, Adler AJ, Berlyne GM. Inhibition of superoxide dismutase activity by silicon. J Trace Elem Electrolytes Health Dis. 1990;97–9
Bergonzi G, Paties C, Vassallo G et al. Dextran deposits in tissues of patients undergoing hemodialysis. Nephrol Dial Transplant. 1990;5:54–8
D’Haese PC, Van Landeghem GF, De Broe ME. Increased silicon levels in dialysis patients due to the high silicon content in the drinking water, inadequate water treatment procedures, and concentrate contamination: a multicentre study (reply letter to the editor). Nephrol Dial Transplant. 1996;11:1188–9
Saldanha LF, Gonick HC, Rodriguez HJ, Marmelzat JA, Repique EV, Marcus CL. Silicon related syndrome in dialysis patients. Nephron. 1997;77:48–56
Sips AJAM, van der Vijgh JF. Strontium. In: Seiler HG, Sigel I, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994: 577–85
D’Haese PC, Schrooten I, Goodman WG et al. Increased bone strontium levels in hemodialysis patients with osteomalacia. Kidney Int. 2000;57:1107–14
Schrooten I, Cabrera W, Dauwe S et al. Strontium causes osteomalacia in chronic renal failure rats. Kidney Int. 1998;54:448–56
Schrooten I, Behets GJS, Cabrera WE et al. Dose-dependent effects of strontium on bone of chronic renal failure rats. Kidney Int. 2003;63:927–35
Verberckmoes SC, De Broe ME, D’Haese PC. Dose-dependent effects of strontium on osteoblast function and mineralization. Kidney Int. 2003;64:534–43
Marchante-Gayon JM, Sanchez-Uria JE, Sanz-Medel A. Serum and tissue selenium contents related to renal disease and colon cancer as determined by electrothermal atomic absorption spectrometry. J Trace Elem Med Biol. 1997; 10:229–36.
Neve J, Vertongen F, Molle L. Selenium deficiency. Clin Endocrinol Metab. 1985;14:629–56
Willett WC, Morris JS, Pressel S et al. Prediagnostic serum selenium and risk of cancer. Lancet. 1983;2:130–3
Bonomini M, Forster S, De Risio F et al. Effects of selenium supplementation on immune parameters in chronic uraemic patients on haemodialysis. Nephrol Dial Transplant. 1995;10:1654–61
Rukgauer M, Schmitt Y, Schneider H, Krusejarres JD. Trace element balance in patients undergoing hemodialysis. Trace Elem Electrolytes. 1994;11:155–68
Borguet F, Cornelis R, Delanghe J, Kambert MC, Lameire N. Study of the chromium binding to plasma of patients on continuous ambulatory peritoneal dialysis. Clin Chim Acta. 1995;238:71–84
D’Haese PC, Couttenye M-M, Lamberts LV et al. Al, Fe, Pb, Cd, Cu, Zn, Cr, Mg, Sr and Ca content in bone of endstage renal failure patients. Clin Chem. 1999;45:1548–56
Mahajan SK, Bowersox EM, Rye DL et al. Factors underlying abnormal zinc metabolism in uremia. Kidney Int. 1989;36:S269–73
Richard MJ, Arnud J, Jurkovitz C et al. Trace element lipid peroxidation abnormalities in patients with chronic renal failure. Nephron. 1991;57:10–15
Türk S, Bozfakioglu S, Ecder ST et al. Effects of zinc supplementation on the immune system and on antibody response to multivalent influenza vaccine in hemodialysis patients. Int J Artif Organs. 1998;21:274–8
Thomson NP, Stevens BJ, Humphery TJ, Atkins RC. Comparison of trace elements in peritoneal dialysis, hemodialysis and uremia. Kidney Int. 1983;23:9–14
Drazniowsky M, Parkinson IS, Ward MK, Channon SM, Kerr DNS. Raised serum nickel concentrations in chronic renal failure. Proc EDTA-ERA. 1984;21:241–6
Hosokawa S, Yoshida O. Serum vanadium levels in chronic hemodialysis patients. Nephron. 1993;64:388–94
Sakurai H, Nishida M, Koyama M, Takada J. Occurrence of vanadium ion in serum albumins. Biochem Biophys Acta. 1987;924:562–3
De Kimpe J, Cornelis R, Mees L, Van Lierde S, Vanholder R. More than tenfold increase of arsenic in serum of packed cells of chronic hemodialysis patients. Am J Nephrol. 1993;13:429–34
Iffland R. Arsenic. In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994:237–53
Zhang X, Cornelis R, Mees L, Vanholder R, Lameire N. Chemical speciation of arsenic in serum of uraemic patients. Analyst. 1998;123:3–17
Gessner BD, Beller M, Middaugh JP, Whitford GM. Acute fluoride poisoning from a public water system. N Engl J Med. 1994;330:95–9
Hillier S, Cooper C, Kellingray S, Russell G, Hughes H, Coggon D. Fluoride in drinking water and risk of hip fracture in the UK: a case-control study. Lancet. 2000;355: 265–9
Turner CH, Owan I, Brizendine EJ, Zhang W, Wilson ME, Dunipace AJ. High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency. Bone. 1996;19:595–601
Al-Wakeel JS, Mitwalli AH, Huraib S et al. Serum ionic fluoride levels in haemodialysis and continuous ambulatory peritoneal dialysis patients. Nephrol Dial Transplant. 1997;12:1420–4.
Ittel TH, Gladziwa U, Sieberth HG. Synergistic effect of 1,25-vitamin D3 and fluoride on bone aluminum accumulation. Bone. 1993;14:427–32.
Alfrey AC. Gastrointestinal absorption of aluminum. Clin Nephrol. 1985;24:S84–7.
Hunt CD, Herbel JL, Odso JP. Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res. 1994;9:171–82
Krachler M, Scharfetter H, Wirnsberger GH. Evaluation of concentrations of cesium and rubidium in whole blood, plasma, and serum in different diseases. Trace Elem Electrolytes. 1998;15:22–7
Keller T, Gehring L, Loser T. Trace element disorders in patients with chronic kidney failure during dialysis. Nieren Hochdruckkrankheiten. 1998;27:522–32
Gallieni M, Brancaccio D, Cozzolino M, Sabbioni E. Trace elements in renal failure: are they clinically important? Nephrol Dial Transplant. 1996;11:1232–5
Carroll BJ, Sharp PT. Rubidium and lithium: opposite effects on amine-mediated excitement. Science. 1971; 172:1355–7
Stiefel EJ. Proposed molecular mechanism for the action of molybdenum in enzymes: coupled proton and electron transfers. Proc Natl Acad Sci USA. 1973;70:988
Moriwaki Y, Yamamoto T, Higashino K. Distribution and pathophysiologic role of molybdenum-containing enzymes. Histol Histopathol. 1997;12:513–24
Johnson S. Effect of gradual accumulation of iron, molybdenum and sulfur, slow depletion of zinc and copper, ethanol and fructose ingestion and phlebotomy in gout. Med Hypotheses. 1999;53:407–12
Anke M, Glei M. Molybdenum. In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994:495–501
Hsu WA, Lee KC, Lin SL et al. Clinical manifestations of trace metal abnormality in hemodialysis patients: a multicenter collaborative study. Dialy Transplant. 1997;26:15
Lyon TDB, Fell GS. Trace elements in autopsy tissue. Food Chem. 1992;43:299–306
D’Haese PC. Aluminum accumulation in patients with chronic renal failure: Monitoring, diagnosis, therapy (Ph.D thesis). Universities of Antwerp/Amsterdam, 1989
Ritz E, Koster J, De Broe ME et al. Does lead exposure contribute to the deterioration of renal function in patients with renal disease? Nephrol Dial Transplant. 1986;1: 206–7
D’Haese PC, Couttenye M-M, Goodman WG et al. Use of the low-dose desferrioxamine test to diagnose and differentiate between patients with aluminum-related bone disease, increased risk for aluminum toxicity, or aluminum overload. Nephrol Dial Transplant. 1995;10:1874–84
D’Haese PC, Lamberts LV, Verpooten GA et al. Urinary and biliary excretion of aluminoxamine and ferrioxamine in dogs with various renal function. Kidney Int. 1994;45: 76–84
Andress DL, Nebeker HG, Ott SM et al. Bone histologic response to deferoxamine in aluminum-related bone disease. Kidney Int. 1987;31:1344–50
Vasilakakis DM, D’Haese PC, Lamberts LV, Lemoniatou E, Digenis PN, De Broe ME. Removal of aluminoxamine and ferrioxamine by charcoal hemoperfusion and hemodialysis. Kidney Int. 1992;41:1400–7
Lameire N, Cornelis R, Vanholder R. Does abnormal trace element metabolism contribute to dialysis patient morbidity? Semin Dial. 1999;12:15–24
Nomiyama K, Nomiyama H. Some considerations in the determination of metals in biological materials. Nephrol Dial Transplant. 1989;4(Suppl.):114–19
Templeton DM. Inductively coupled plasma-atomic emission spectrometry (ICP-AES) and inductively coupled plasma-mass spectrometry (ICP-MS). In: Seiler HG, Sigel A, Sigel H, editors. Handbook on Metals in Clinical and Analytical Chemistry. New York: Marcel Dekker, 1994:167–80.
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D’Haese, P.C., De Broe, M.E. (2004). Trace elements in dialysis patients. In: Hörl, W.H., Koch, K.M., Lindsay, R.M., Ronco, C., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2275-3_37
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