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Neurological and neuromuscular disorders in dialysis patients

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Replacement of Renal Function by Dialysis
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Abstract

The number of patients suffering from chronic renal failure and treated with dialysis is increasing worldwide. Apart from spina bifida and paraplegia it is relatively uncommon for patients with primary neurological disease to develop chronic renal failure, whereas renal failure commonly affects the nervous system. In addition, the main expansion in dialysis programs in the economically affluent countries has been due to the increased number of older patients, who often have additional co-morbidities, with increased prevalence and risk of cerebrovascular disease. Both concomitant drug therapy and the dialysis procedure itself may either directly cause neurological complications, or exacerbate underlying pre-existing conditions.

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References

  1. Mathew RJ, Rabin P, Stone WJ, Wilson WH. Regional cerebral blood flow in dialysis encephalopathy and primary degenerative dementia. Kidney Int. 1985;28:64–8.

    Article  PubMed  CAS  Google Scholar 

  2. Fazekas G, Fazekas F, Schimdt R et al. Pattern of cerebral blood flow and cognition in patients undergoing chronic hemodialysis treatment. Nucl Med Commun. 1996;17:603–8.

    Article  PubMed  CAS  Google Scholar 

  3. Marsh JT, Brown WS, Wolcott D et al. RHuEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int. 1991;39:155–63.

    Article  PubMed  CAS  Google Scholar 

  4. Lass P, Buscombe JR, Harber M, Davenport A, Hilson AJ. Cognitive impairment in patients with renal failure is associated with multi-infarct dementia. Clin Nucl Med. 1999; 24:561–5.

    Article  PubMed  CAS  Google Scholar 

  5. Burns DJ, Bates D. Neurology and the kidney. J Neurol Neurosurg Psychiatry. 1998;65:810–21.

    Article  Google Scholar 

  6. Lederman RJ, Henry CE. Progressive dialysis encephalopathy. Ann Neurol. 1978;4:199–204.

    Article  PubMed  CAS  Google Scholar 

  7. Madonick MJ, Berke K, Schiffer I. Pleocytosis and meningeal signs in uremia: report on 62 cases. Arch Neurol Psychiatry. 1950;64:431–7.

    Article  PubMed  CAS  Google Scholar 

  8. Davenport A, Bramley PN. Cerebral function analysing monitor and visual evoked potentials as a non-invasive method of detecting cerebral dysfunction in patients with acute hepatic and renal failure treated with intermittent hemofiltration. Renal Failure. 1993;15:515–22.

    Article  PubMed  CAS  Google Scholar 

  9. Pratt H, Brodsky G, Goldsher M et al. Auditory brain stem evoked potentials in patients undergoing dialysis. Electroenceph Clinical Neurophysiol. 1986;63:18–24.

    Article  CAS  Google Scholar 

  10. Marsh JT, Brown WS, Wolcott D, Landsverk J, Nissenson AR. Electrophysiological indices of CNS function in hemodialysis and CAPD. Kidney Int. 1986;30:957–63.

    Article  PubMed  CAS  Google Scholar 

  11. Di Paolo B, Di Liberato L, Fiederling B et al. Effects of uremia and dialysis on brain electrophysiology after recombinant erythropoietin treatment. ASAIO J. 1992;38: M477–80.

    Article  PubMed  Google Scholar 

  12. Strange K. Regulation of solute and water balance and cell volume in the central nervous system. J Am Soc Nephrol. 1992;3:12–27.

    PubMed  CAS  Google Scholar 

  13. Olsen S. The brain in uremia. Acta Psychiatr Scand. 1961;36(Suppl. 156):1–12.

    CAS  Google Scholar 

  14. Guisado R, Arieff AI, Massry SG. Changes in the electroencephalogram in acute uremia: effects of parathyroid hormone and brain electrolytes. J Clin Invest. 1975;55: 738–40.

    Article  PubMed  CAS  Google Scholar 

  15. Cogan MG, Covey CM, Arieff AI, Massry SG. Central nervous system manifestations of hyperparathyroidism. Am J Med. 1978;65:963–70.

    Article  PubMed  CAS  Google Scholar 

  16. Fraser CL. Neurological manifestations of the uremic state. In: Arieff AI, Griggs RC, editors. Metabolic Brain Dysfunction in Systemic Disorders. Boston: Little Brown, 1988:139:66–76.

    Google Scholar 

  17. Ni Z, Smogorzewski M, Massry SG. Derangements in acetylcholine metabolism in brain synaptosomes in chronic renal failure. Kidney Int. 1993;44:630–7.

    Article  PubMed  CAS  Google Scholar 

  18. De Deyn PP, Marescau B, D’Hooge R, Possemiers I, Nagler J, Mahler C. Guanidino compound levels in brain regions of non-dialyzer uremic patients. Neurochem Int. 1995;27: 227–37.

    Article  PubMed  Google Scholar 

  19. Costigan MG, Callaghan CA, Lindup WE. Hypothesis: is accumulation of a furan dicarboxylic acid (3-carboxy4-methy1–5-propy1–2-furanpropanoic acid) related to the neurological abnormalities in patients with renal failure? Nephron. 1996;73:169–73.

    Article  PubMed  CAS  Google Scholar 

  20. Geissler A, Frund R, Kohler S, Eichhorn HM, Kramer BK, Feuerbach S. Cerebral metabolite patterns in dialysis patients: evaluation with H-1 MR spectroscopy. Radiology. 1995;194:693–7.

    PubMed  CAS  Google Scholar 

  21. Michaelis T, Videen JS, Linsey MS, Ross BD. Dialysis and transplantation affect cerebral abnormalities of end-stage renal disease. J Magnet Reson Imag. 1996;6:341–7.

    Article  CAS  Google Scholar 

  22. Nadgrodkiewicz K. Acute hyponatremic encephalopathy in a patient on chronic hemodialysis program — a case report. Neurol Neurochirurg Polska 1993;27:111–15.

    CAS  Google Scholar 

  23. Peterson B, Khanna S, Fisher B, Marshall L. Prolonged hypernatremia controls elevated intracranial pressure in head injured patients. Crit Care Med. 2000;28:1136–43.

    Article  PubMed  CAS  Google Scholar 

  24. Davenport A, Goel S, Mackenzie JC. Audit of the use of calcium carbonate as a phosphate binder in 100 patients treated with continuous ambulatory peritoneal dialysis (CAPD). Nephrol Dial Transplant. 1992;7:632–5.

    PubMed  CAS  Google Scholar 

  25. Davenport A, Aulton K, Payne RB, Will EJ. Hyperlactatemia and increasing metabolic acidosis in hepatorenal failure treated by hemofiltration. Renal Failure. 1990;12:99–101.

    Article  PubMed  CAS  Google Scholar 

  26. Veech RL. The untoward effects on anions of dialysis fluids. Kidney Int. 1991;34:587–9.

    Article  Google Scholar 

  27. Thara M, Ito T, Yanagihara C, Nishimura Y. Wernicke’s encephalopathy associated with hemodialysis: report of two cases and review of the literature. Clin Neurol Neurosurg. 1999;101:118–21.

    Article  Google Scholar 

  28. Winney RJ, Kean DM, Best JJK, Smith MA. Changes in brain water with hemodialysis. Lancet. 1986;2:1107–8.

    Article  PubMed  CAS  Google Scholar 

  29. Bertrand YM, Hermant A, Mahieu P, Roeb J. Intracranial pressure changes in patients with head trauma during hemodialysis. Intens Care Med. 1983;9:321–3.

    Article  CAS  Google Scholar 

  30. Rosen SM, O’Connor K, Shaldon S. Hemodialysis disequilibrium syndrome. Br Med J. 1964;2:672–5.

    Article  PubMed  CAS  Google Scholar 

  31. Kjellstrand CM, Teehan BP. Acute renal failure. In: Jacobs C, Kjellstrand CM, Koch KM, Winchester JF, editors. Replacement of Renal Function by Dialysis, 4th edn. Boston: Kluwer, 1996:821–62.

    Chapter  Google Scholar 

  32. Kennedy AC, Linton AL, Luke RG, Renfrew S, Dinwoodie A. The pathogenesis and prevention of cerebral dysfunction during dialysis. Lancet. 1964;1:790–3.

    Article  PubMed  CAS  Google Scholar 

  33. Arieff AI, Guisado R, Massry SG, Lazarowitz VC. Central nervous system pH in uremia and the effects of hemodialysis. J Clin Invest. 1976;58:306–10.

    Article  PubMed  CAS  Google Scholar 

  34. Arieff AI. Dialysis disequilibrium syndrome: current concepts on pathogenesis and prevention. Kidney Int. 1994; 45:629–35.

    Article  PubMed  CAS  Google Scholar 

  35. Silver SM, Sterns RH, Halperin ML. Brain swelling after dialysis: old urea or new osmoles? Am J Kidney Dis. 1996; 28:1–13.

    Article  PubMed  CAS  Google Scholar 

  36. Goldsmith DJA, Forni LG, Hilton PJ. Bicarbonate therapy and intracellular acidosis. Clin Sci. 1997;93:593–8.

    PubMed  CAS  Google Scholar 

  37. Davenport A, Will EJ, Davison AM. Early changes in intracranial pressure during hemofiltration treatment in patients with grade IV hepatic encephalopathy and acute oliguric renal failure. Nephrol Dial Transplant. 1990;5: 192–8.

    Article  PubMed  CAS  Google Scholar 

  38. Ishida I, Hirakata H, Sugimori H et al. Hemodialysis causes severe orthostatic reduction in cerebral blood flow velocity in diabetic patients. Am J Kidney Dis. 1999;34:1096–104.

    Article  PubMed  CAS  Google Scholar 

  39. Davenport A. Renal replacement therapy in patients at risk of cerebral edema/hypoxia. New Horizons. 1995;3:717–27.

    PubMed  CAS  Google Scholar 

  40. Davenport A, Finn R, Goldsmith HJ. The management of patients with renal failure complicated by cerebral edema. Blood Purif. 1989;7:203–9.

    Article  PubMed  CAS  Google Scholar 

  41. Jost CM, Agarwal R, Khair-el-din T, Grayburn PA, Victor RG, Henrich WL. Effects of cooler temperature dialysate on hemodynamics stability in ‘problem’ patients. Kidney Int. 1993;41:961–4.

    Google Scholar 

  42. Davenport A. Renal replacement therapy in the patient with acute brain injury. Am J Kidney Dis. 2001;37:457–66.

    Article  PubMed  CAS  Google Scholar 

  43. Davenport A. Is there a role for continuous renal replacement therapies in patients with liver and renal failure? Kidney Int. 1999;56(Suppl. 72):S62–5.

    Article  Google Scholar 

  44. Fazekas G, Fazekas F, Schmidt R, Kapeller P, Offenbacher H, Krejs GJ. Brain MR findings and cognitive impairment in patients undergoing chronic hemodialysis treatment. J Neurol Sci. 1995;134:83–8.

    Article  PubMed  CAS  Google Scholar 

  45. Kamata T, Hishida A, Takita T et al. Morphological abnormalities in the brain of chronically hemodialysed patients without cerebrovascular disease. Am J Nephrol. 2000;20:27–31.

    Article  PubMed  CAS  Google Scholar 

  46. Schmidt AM, Yan SD, Wautier JL, Stern D. Activation of receptor for advanced glycation end products; a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res. 1999;84:489–97.

    Article  PubMed  CAS  Google Scholar 

  47. Ezzeddine MA, Primavera JM, Rosand J, Hedley-Whyte ET, Rordorf G. Clinical characteristics of pathologically proved cholesterol emboli to the brain. Neurology. 2000;54:1681–3.

    Article  PubMed  CAS  Google Scholar 

  48. Savazzi GM, Cusmano F, Bergamaschi E, Vinci S, Allegri L, Garini G. Hypertension as an etiological factor in the development of cerebral atrophy in hemodialyzed patients. Nephron. 1999;81:17–24.

    Article  PubMed  CAS  Google Scholar 

  49. Guidelines Subcommittee. 1999 World Health Organization International Society of Hypertension guidelines for the management of hypertension. J Hypertens. 1999;11:905–18.

    Google Scholar 

  50. Warlow CP. Cerebrovascular disease. In: Weatherall DJ, Ledingham JGG, Warrell DA, editors. Oxford Textbook of Medicine, 3rd edn. Oxford: Oxford University Press, 1996: 3946–64.

    Google Scholar 

  51. Foley RN, Parfrey PS. Complications of long term dialysis — cardiovascular complications and cardiac risk factor interventions. In: Brown EA, Parfrey PS, editors. Complications of Long-term Dialysis. Oxford: Oxford University Press, 1999:29–52.

    Google Scholar 

  52. Jackson TL, Farmer CK, Kingswood C, Vickers S. Hypotensive ischemic optic atrophy and peritoneal dialysis. Am J Ophthalmol. 1999;128:109–11.

    Article  PubMed  CAS  Google Scholar 

  53. Kawamura M, Fijimoto S, Hisanga S, Yamamoto Y, Eto T. Incidence, outcome, and risk factors of cerebrovascular events in patients undergoing maintenance hemodialysis. Am J Kidney Dis. 1998;31:991–6.

    Article  PubMed  CAS  Google Scholar 

  54. Weber DL, Regan T, Leeds M. Intracranial hemorrhage during hemodialysis. NY State J Med. 1972;7:1853–4.

    Google Scholar 

  55. Fraser CL, Arieff AI. Metabolic encephalopathy as a complication of renal failure: mechanisms and mediators. New Horizons. 1994;2:518–26.

    PubMed  CAS  Google Scholar 

  56. D’Haese PC, De Broe ME. Aluminium, silicon, and strontium accumulation/intoxication as a complication of longterm dialysis. In: Brown EA, Parfrey PS, editors. Complications of Long-term Dialysis. Oxford: Oxford University Press, 1999:104–20.

    Google Scholar 

  57. Davenport A, Roberts NB. The accumulation of aluminium in patients with acute renal failure. Nephron. 1989;52: 253–8.

    Article  PubMed  CAS  Google Scholar 

  58. Freundlich M, Zilleruelo G, Abitbol C, Strauss J, Faugere MC, Malluche HH. Infant formula as a cause of aluminium toxicity in neonatal uremia. Lancet. 1985;2: 527–9.

    Article  PubMed  CAS  Google Scholar 

  59. Davenport A, Davison AM, Will EJ, Newton KE, Toothill C. Aluminium mobilisation following renal transplantation and the possible effect on susceptibility to bacterial sepsis. Q J Med. 1991;289:407–23.

    Google Scholar 

  60. Reusche E, Seydel U. Dialysis associated encephalopathy: light and electron microscopic morphology and topography with evidence of aluminium by laser microprobe mass analysis. Acta Neuropathol. 1993;86:249–58.

    Article  PubMed  CAS  Google Scholar 

  61. Beccari M. Seizures in dialysis patients treated with recombinant erythropoietin. Review of the literature and guidelines for prevention. Int J Artif Organs. 1994;17:5–13.

    PubMed  CAS  Google Scholar 

  62. Lok P. Stressors, coping mechanisms and quality of life among dialysis patients in Australia. J Adv Nurs. 1996; 23:873–81.

    Article  PubMed  CAS  Google Scholar 

  63. Nissenson AR. Recombinant human erythropoietin and renal anemia: molecular biology, clinical efficacy, and nervous system effects. Ann Intern Med. 1991;114:402–16.

    Article  PubMed  CAS  Google Scholar 

  64. Pierratos A, Ouwendyk M. Nocturnal hemodialysis: five years later. Semin Dial. 1999;12:419–23.

    Article  Google Scholar 

  65. British Medical Association and Royal Pharmaceutical Society of Great Britain. British National Formulary. Appendix 3: Renal Impairment, Vol. 40. Oxford: Pharmaceutical Press, 2000;633–43.

    Google Scholar 

  66. Jamal JA, Joh J, Bastani B. Removal of morphine with the new high-efficiency and high-flux membranes during hemofiltration and hemodiafiltration. Nephrol Dial Transplant. 1998;13:1535–7.

    Article  PubMed  CAS  Google Scholar 

  67. Boot BP, McGregor IS, Hall W. MDMA (Ecstasy) neurotoxicity: assessing and communicating the risks. Lancet. 2000;355:1818–21.

    Article  PubMed  CAS  Google Scholar 

  68. Nzerue CM, Hewan-Lowe K, Riley LJ Jr. Cocaine and the kidney: a synthesis of pathophysiologic and clinical perspectives. Am J Kidney Dis. 2000;35:783–95.

    Article  PubMed  CAS  Google Scholar 

  69. Ciechanover M, Peresecenschi G, Aviram A, Steiner JE. Malrecognition of taste in uremia. Nephron. 1980;26: 20–2.

    Article  PubMed  CAS  Google Scholar 

  70. Antonelli AR, Bonfioli F, Garrubba V et al. Audiological findings in elderly patients with chronic renal failure. Acta Oto-Laryngol. 1990;476(Suppl.):54–68.

    CAS  Google Scholar 

  71. Niedzielska G, Katska E, Sikora P, Szajner-Milart I. ABR differences before and after dialyses. Int J Pediatr Otorhinolaryngol. 1999;48:27–9.

    Article  PubMed  CAS  Google Scholar 

  72. Schwankhaus JD, Massucci EF, Kurtzke JF. Cefazolin induced encephalopathy in a uremic patient. Ann Neurol. 1985;17: 211–13.

    Article  PubMed  CAS  Google Scholar 

  73. Cheung WC, Lo CY, Lo WK, Cheng 1K. Isoniazid inducing encephalopathy in dialysis patients. Tubercle Lung Dis. 1993;74:136–9.

    Article  CAS  Google Scholar 

  74. Davenport A, Goels S, Mackenzie JC. Neurotoxicity of acyclovir in patients with end-stage renal failure treated with continuous ambulatory peritoneal dialysis (CAPD). Am J Kidney Dis. 1992;20:647–9.

    PubMed  CAS  Google Scholar 

  75. Wang HC, Brown P, Lees AJ. Acute movement disorders with bilateral basal ganglia lesions in uremia. Movement Disorders 1998;13:952–7.

    Article  PubMed  CAS  Google Scholar 

  76. Meltzer CC, Wells SW, Becher MW, Flanigan KM, Oyler GA, Lee RR. AIDS related MR hyperintensity of the basal ganglia. Am J Neuroradiol. 1998;19:83–9.

    PubMed  CAS  Google Scholar 

  77. Alfrey AC. Organ and metabolic complications: trace elements. In: Jacobs C, Kjellstrand CM, Koch KM, Winchester JF, editors. Replacement of Renal Function by Dialysis, 4th edn. Dordrecht: Kluwer, 1996:1260–70.

    Chapter  Google Scholar 

  78. Burgess KR, Burgess EE, Whitelaw WA. Impaired ventilatory response to carbon dioxide in patients with chronic renal failure: implications for the intensive care unit. Crit Care Med. 1994;22:413–18.

    Article  PubMed  CAS  Google Scholar 

  79. Strangio D, Locking-Cusolito H. Incidence of sleep pattern disturbance in a hemodialysis sample. J CANNT. 1999;9: 24–30.

    PubMed  CAS  Google Scholar 

  80. Puntriano M. The relationship between dialysis adequacies and sleep problems in hemodialysis patients. ANNA J. 1999;26:405–7.

    CAS  Google Scholar 

  81. Kraus MA, Hamburger RJ. Sleep apnea in renal failure. Adv Pert Dial. 1997;13:88–92.

    CAS  Google Scholar 

  82. Holley JL, Nespor S, Rault R. A comparison of reported sleep disorders in patients on chronic hemodialysis and continuous peritoneal dialysis. Am J Kidney Dis. 1992; 19:156–61.

    PubMed  CAS  Google Scholar 

  83. Benz RL, Pressman MR, Hovick ET, Peterson DD. A preliminary study of the effects of correction of anemia with recombinant human erythropoietin therapy on sleep, sleep disorders, and day time sleepiness in hemodialysis patients (the SLEEPO study). Am J Kidney Dis. 1999;34:1089–95.

    Article  PubMed  CAS  Google Scholar 

  84. Kamijo M, Yagihashi S, Kida K, Narita S, Nakata F. An autopsy case of chronic germanium intoxication presenting peripheral neuropathy, spinal ataxia, and chronic renal failure. Clin Neurol. 1991;31:191–6.

    CAS  Google Scholar 

  85. El-Shahawy MA, Gadallah MF, Campese VM. Tuberculosis of the spine in patients with end-stage renal disease. Am J Nephrol. 1994;14:55–9.

    Article  PubMed  CAS  Google Scholar 

  86. Jadoul M, De Broe ME. β2-Microglobulin amyloidosis. In: Brown EA, Parfrey PS, editors. Complications of Long-term Dialysis. Oxford: Oxford University Press, 1999:121–44.

    Google Scholar 

  87. Thomas PK. Screening for peripheral neuropathy in patients treated by chronic hemodialysis. Muscle Nerve. 1978;1: 396–9.

    Article  PubMed  CAS  Google Scholar 

  88. Schaumburg HH, Berger AR, Thomas PK. Uremic neuropathy. In: Davis RA, editor. Disorders of Peripheral Nerves, 2nd edn. Philadelphia: WB Saunders, 1992:156–63.

    Google Scholar 

  89. Mallamaci F, Zoccali C, Cicarelli M, Briggs JD. Autonomic function in uremic patients treated by hemodialysis or CAPD and in transplant patients. Clin Nephrol. 1986;25:175–79.

    PubMed  CAS  Google Scholar 

  90. Jurcic D, Bago J, Eljuga D et al. Features of uremic neuropathy in long term dialysis. Colleg Antropol. 1998;22: 119–25.

    CAS  Google Scholar 

  91. Chou FF, Lee CH, Chen JB. General weakness as an indication for parathyroid surgery in patients with secondary. Arch Surg. 1999;134:1108–11.

    Article  PubMed  CAS  Google Scholar 

  92. Chou FF, Ho JC, Huang SC, Sheen-Chen SM. A study on pruritus after parathyroidectomy for secondary hyperparathyroidism. J Am Coll Surgeons. 2000;190:65–70.

    Article  CAS  Google Scholar 

  93. Murphy M, Carmichael AJ. Renal itch. Clin Exp Dermatol. 2000;25:103–6.

    Article  PubMed  CAS  Google Scholar 

  94. Robles NR, Solis M, Albarran L, Esparrago JF, Roncero F. Sympathetic skin response in hemodialysis patients: correlation with nerve conduction studies and adequacy of dialysis. Nephron. 1999;82:12–16.

    Article  PubMed  CAS  Google Scholar 

  95. Winkelman JW, Chertow GM, Lazarus JM. Restless legs syndrome in end-stage renal disease. Am J Kidney Dis. 1996;28;372–8.

    Article  PubMed  CAS  Google Scholar 

  96. Nielsen VK. The peripheral nerve function in chronic renal failure. V. Sensory and motor conduction velocity. Acta Med Scand. 1973;194:445–50.

    Article  PubMed  CAS  Google Scholar 

  97. Oh SJ, Clements RS, Lee YW, Diethelm AG. Rapid improvement in nerve conduction velocity following renal transplantation. Ann Neurol. 1978;4:369–72.

    Article  PubMed  CAS  Google Scholar 

  98. Forno L, Alston W. Uremic polyneuropathy. Acta Neurol Scand. 1967;43:640–6.

    Article  PubMed  CAS  Google Scholar 

  99. Dyan AD, Gardner-Thorpe C, Down PF, Gleadle RI. Peripheral neuropathy in uremia. Neurology. 1970;20;649–52.

    Article  Google Scholar 

  100. Sobh MA, El-Tantawy AH, Said E et al. Effect of treatment of anemia with erythropoietin on neuromuscular function in patients on long term dialysis. Scand J Urol Nephrol. 1992;26:65–9.

    Article  PubMed  CAS  Google Scholar 

  101. Hörl WH. The patient with uremia. In: Davison AM, Cameron JS, Grünfeld JP, Kerr DNS, Ritz E, Winearls CG, editors. Oxford Textbook of Clinical Nephrology, 2nd end. Oxford: Oxford Medical Publications, 1998:1822–36.

    Google Scholar 

  102. Sterzel RB, Semar M, Lonergan ET, Treser G, Lange K. Relationship of nervous tissue transketolase to the neuropathy in chronic uremia. J Clin Invest. 1971;50:2295–7.

    Article  PubMed  CAS  Google Scholar 

  103. Dobbelstein H, Körner WF, Mempel W, Grosse-Wilde H, Edel HH. Vitamin B6 deficiency in uremia and its implication for the depression of immune responses. Kidney Int. 1974;5:223–6.

    Article  Google Scholar 

  104. Garnaas KR, Windebank AJ, Blexrud MD, Kurtz SB. Ultrastructural changes produced in dorsal root ganglia in vitro by exposure to ethylene oxide from hemodialyzers. J Neuropathol Exp Neurol. 1991;50:256–62.

    Article  PubMed  CAS  Google Scholar 

  105. Davenport A. Neurological disorders in patients with acute renal failure. In: Ronco C, Bellomo R, editors. Critical Care Nephrology. London: Kluwer, 1998:1081–104.

    Chapter  Google Scholar 

  106. Klein C, Halvey A, Gandelman-Marton R et al. Nerve conduction abnormalities in the arms of patients with arterio-venous fistula. Renal Failure. 1996;18:85–9.

    Article  PubMed  CAS  Google Scholar 

  107. Hye RJ, Wolf YG. Ischemic monomelic neuropathy: an under-recognized complication of hemodialysis access. Ann Vasc Surg. 1994;8:578–82.

    Article  PubMed  CAS  Google Scholar 

  108. Vita G, Savica V, Milone S, Trusso A, Bellinghieri G, Messina C. Uremic autonomic neuropathy: recovery following bicarbonate hemodialysis. Clin Nephrol. 1996;45: 56–60.

    PubMed  CAS  Google Scholar 

  109. Auinger M, Wanke T, Merkle M et al. Effect of autonomic neuropathy on ventilatory response to progressive hypercapnia in dialysis patients. Nephrol Dial Transplant. 1995; 10:825–30.

    PubMed  CAS  Google Scholar 

  110. Ligtenberg G, Blankestijn PJ, Oey PL, Wienke GH, van Huffelen AC, Koomans HA. Cold stress provokes sympathoinhibitory presyncope in healthy subjects and hemodialysis patients with low cardiac output. Circulation. 1997;95:2271–6.

    Article  PubMed  CAS  Google Scholar 

  111. Jassal SV, Douglas JF, Stout RW. Prevalence of central autonomic neuropathy in elderly dialysis patients. Nephrol Dial Transplant. 1998;13:1702–8.

    Article  PubMed  CAS  Google Scholar 

  112. Sherman FP. Impotence in patients with chronic renal failure on dialysis: its frequency and etiology. Fertil Steril. 1975; 26:221–3.

    PubMed  CAS  Google Scholar 

  113. Toorians AW, Janssen E, Laan E et al. Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. Nephrol Dial Transplant. 1997; 12:2654–63.

    Article  PubMed  CAS  Google Scholar 

  114. Pinciaroli AR. Hormonal changes in daily hemodialysis. Semin Dial. 1999;12:455–61.

    Article  Google Scholar 

  115. Kaufman JM, Hatzichristou DG, Mulhall JP, Fitch WP, Goldstein I. Impotence and chronic renal failure: a study of the hemodynamic pathophysiology. J Urol. 1994;151: 612–18.

    PubMed  CAS  Google Scholar 

  116. Gilbert TB, Jacobs SC, Quaddoura AA. Deafness and prolonged neuromuscular blockade following single dose peritoneal neomycin irrigation. Can J Anesth. 1998;45: 568–70.

    Article  PubMed  CAS  Google Scholar 

  117. DiGrandis D, Mezzina C, Fiaschi A, Pinelli P, Bazzato G, Morachiello M. Myasthenia due to carnitine. J Neurol Sci. 1980;46:365–71.

    Article  Google Scholar 

  118. Kasuga A, Maruyama H, Sato T, Nogawa S, Mitamura H, Saruta T. Myasthenia like syndrome induced by overdosage of cibenzoline. Intern Med. 1996;35:512–14.

    Article  PubMed  CAS  Google Scholar 

  119. Chang JM, Hwang SJ, Kuo HT et al. Fatal outcome after ingestion of star fruit (Averrhoa carambola) in uremic patients. Am J Kidney Dis. 2000;35:189–93.

    Article  PubMed  CAS  Google Scholar 

  120. Johansen KL. Physical functioning and exercise capacity in patients on dialysis. Adv Renal Replace Ther. 1999;6: 141–8.

    CAS  Google Scholar 

  121. Gambhir IS, Bayen PK, Singh RG, Usha R, Katiyar BC. Neuromuscular changes in acute renal failure. J Assoc Phys India. 1995;43:263–4.

    CAS  Google Scholar 

  122. Howe RC, Wombolt DG, Michie DD. Analysis of tonic muscle activity and muscle cramps during hemodialysis. J Dial. 1978:2:85–99.

    PubMed  CAS  Google Scholar 

  123. Ritz R, Boland R, Kreusser W. Effects of vitamin D and parathyroid hormone on muscle: potential role in uremia. Am J Clin Nutr. 1980;33:1522–29.

    PubMed  CAS  Google Scholar 

  124. Dusunsel R, Poyrazoglu HM, Gunduz Z, Kurtoglu S, Kiris A, Gunes T. Evidence of central hypothyroidism in children on continuous ambulatory peritoneal dialysis. Adv Pert Dial. 1999:15:262–68.

    CAS  Google Scholar 

  125. Fahal IH, Bell GM, Bone MJ, Edwards RHT. Physiological abnormalities of skeletal muscle in dialysis patients. Nephrol Dial Transplant. 1997;12:119–27.

    Article  PubMed  CAS  Google Scholar 

  126. Davenport A, King RF, GJ King, Ironside JW, Will EJ, Davison AM. The effect of treatment with recombinant human erythropoietin on the histological appearance and glycogen content of skeletal muscle in patients with chronic renal failure treated by regular hospital hemodialysis. Nephron. 1993;64:89–94.

    Article  PubMed  CAS  Google Scholar 

  127. Foss MC, Gouveia LMFB, Neto MM, Paccola GMGF, Piccinato CE. Effect of hemodialysis on peripheral glucose metabolism of patients with chronic renal failure. Nephron. 1996;73:48–53.

    Article  PubMed  CAS  Google Scholar 

  128. Sobh MA, Sheashaa H, Tantawy AEH, Ghoneim MA. Study of effect of optimisation of dialysis and protein intake on neuromuscular function in patients under maintenance hemodialysis treatment. Am J Nephrol. 1998;18:399–403.

    Article  PubMed  CAS  Google Scholar 

  129. Fahal IH, Ahmad R, Edwards RHT. Muscle weakness in continuous ambulatory peritoneal dialysis patients. Pert Dial Int. 1996;16(Suppl. 1):S419–23.

    Google Scholar 

  130. Guarnieri G, Togio G, Situlin R et al. Muscle biopsy studies in chronically uremic patients: evidence for malnutrition. Kidney Int. 1983;24:(Suppl. 16):S187–93.

    Google Scholar 

  131. Blank A, Gonen B, Zilberman S, Magora A. Electrophysiological pattern of development of muscle fatigue in patients undergoing dialysis. Electromyogr Clin Neurophysiol. 1986;26:489–97.

    PubMed  CAS  Google Scholar 

  132. Thompson CH, Kemp GJ, Barnes PRJ et al. Uremic muscle metabolism at rest and during exercise. Nephrol Dial Transplant. 1994;9:1600–5.

    PubMed  CAS  Google Scholar 

  133. Sakurauchi Y, Matsumoto Y, Shinzato T et al. Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. Am J Kidney Dis. 1998;32: 258–64.

    Article  PubMed  CAS  Google Scholar 

  134. Thompson CH, Irish AB, Kemp GJ, Taylor DJ, Radda GK. The effect of propionyl L-carnitine on skeletal muscle metabolism in renal failure. Clin Nephrol. 1997;47:372–8.

    PubMed  CAS  Google Scholar 

  135. National Kidney Foundation Kidney Disease Outcomes Quality Initiative. Potential uses for L-carnitine in maintenance dialysis patients. Am J Kidney Dis. 2000;35 (Suppl. 2):S88–92.

    Google Scholar 

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Davenport, A. (2004). Neurological and neuromuscular disorders in dialysis patients. In: Hörl, W.H., Koch, K.M., Lindsay, R.M., Ronco, C., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2275-3_36

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  • DOI: https://doi.org/10.1007/978-1-4020-2275-3_36

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