Dialysis techniques: therapeutic plasma exchange and related techniques

  • W. Samtleben
  • M. J. Lysaght


This chapter describes technical and clinical aspects of the therapeutic removal of macromolecular substances from the circulation. Substances targeted by this therapy exceed a molecular weight of about 50 kDa, and are thus too large to be removed by hemodialysis or hemofiltration. The term ‘plasmapheresis’ refers to the removal of plasma from whole blood. Plasma which has been removed must be replaced by a protein solution in order to maintain the patient’s plasma volume and colloid osmotic pressure; hence the term ‘plasma exchange’. In recent years an increasing number of techniques have become clinically available for processing pheresed plasma to remove offending proteins and to allow the useful and beneficial plasma components to be returned to the patient; these approaches are often termed ‘selective plasma exchange’.


Plasma Exchange Hollow Fiber Familial Hypercholesterolemia Membrane Plasma Therapeutic Plasma Exchange 
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  • W. Samtleben
  • M. J. Lysaght

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