Biosynthesis of the amino acids of the glutamic acid family and its regulation
This reaction is carried out by an enzyme, glutamine synthetase, whose occurrence is not restricted to microorganisms. It is esential not only for the synthesis of glutamine, a building block of proteins. Glutamine contributes also through its amide group to the synthesis of many nitrogen containing substances; in addition, it is an obligatory intermediate in ammonia assimilation in ammonia-limited media.
KeywordsStreptomyces Histidine Lactobacillus Archaea Clostridium
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Glutamine synthetase activity and its regulation by covalent modification. Structure
- S. G. Rhee, P. B. Chock and E. R. Stadtman, Advances in Enzymology, 62, 36–92 (1989).Google Scholar
Glutamine synthetase. Regulation of gene expression
- S. Kustu, K. Sei and J. Keener, in Regulation of gene expression-25 years on, I. R. Booth and C. F. Higgins, eds., Cambridge University Press, Cambridge, pp. 139–154 (1986).Google Scholar
The levels of glutamine synthetase are also regulated by oxidation followed by proteolytic degradation
- L. N. Csonka and A. Baich, in Amino acids: Biosynthesis and Genetic Regulation (K. M. Herrmann and R. L. Somerville, eds.), Addison-Wesley Publishing Company, 35–51 (1983)Google Scholar