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Biosynthesis of the amino acids of the glutamic acid family and its regulation

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Microbial Biochemistry
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Abstract

This reaction is carried out by an enzyme, glutamine synthetase, whose occurrence is not restricted to microorganisms. It is esential not only for the synthesis of glutamine, a building block of proteins. Glutamine contributes also through its amide group to the synthesis of many nitrogen containing substances; in addition, it is an obligatory intermediate in ammonia assimilation in ammonia-limited media.

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Selected references

Glutamine synthetase activity and its regulation by covalent modification. Structure

  • S. G. Rhee, P. B. Chock and E. R. Stadtman, Advances in Enzymology, 62, 36–92 (1989).

    Google Scholar 

  • R. J. Almassy, C. A. Johnson, R. Hanlyn, N. H. Xuong and D. Eisenberg, Nature, 323, 3304–309 (1986).

    Article  Google Scholar 

  • S. H. Liaw C. Pan and D. Eisenberg, Proc. Natl Acad. Sci. U S A, 90, 4996–5000 (1993).

    Article  Google Scholar 

  • R. C. Valentine, B. M. Shapiro and E. R. Stadtman, Biochemistry, 7, 2143–2152 (1968).

    Article  PubMed  CAS  Google Scholar 

  • A. Hesketh, D. Fink, B. Gust, H. U. Rexer, B. Scheel, K. Chater, W. Wohlleben and A. Engels, Mol Microbiol., 46, 319–30 (2002).

    Article  PubMed  CAS  Google Scholar 

Glutamine synthetase. Regulation of gene expression

  • S. Kustu, K. Sei and J. Keener, in Regulation of gene expression-25 years on, I. R. Booth and C. F. Higgins, eds., Cambridge University Press, Cambridge, pp. 139–154 (1986).

    Google Scholar 

  • A. J. Ninfa and B. Magasanik., Proc. Natl. Acad. Sci. USA, 83, 5909–5913 (1986).

    Article  CAS  Google Scholar 

  • J. Keener and S. Kustu, Proc. Natl. Acad. Sci. USA, 85, 4976–4980 (1988).

    Article  CAS  Google Scholar 

The levels of glutamine synthetase are also regulated by oxidation followed by proteolytic degradation

Glutamate synthase

Proline biosynthesis

  • L. N. Csonka and A. Baich, in Amino acids: Biosynthesis and Genetic Regulation (K. M. Herrmann and R. L. Somerville, eds.), Addison-Wesley Publishing Company, 35–51 (1983)

    Google Scholar 

  • J. Kenklies, R. Ziehn, K. Fritsche, A. Pich, and J. R. Andreesen, Microbiology, 145, 819–826 (1999).

    Article  PubMed  CAS  Google Scholar 

Arginine biosynthesis and regulation

  • R. Cunin, N. Glansdorff, A. Pièrard and V. Stalon, Microbiol. Revs., 50, 314–352 (1986).

    CAS  Google Scholar 

  • D. Lim, J. Oppenheim, T. Eckhardt, and W. K. Maas, in Gene expression and regulation: The legacy of Luigi Gorini, 55–63. Excerpta Medica, Amsterdam (1988).

    Google Scholar 

  • A. Abadjieva, K. Pauwels, P. Hilven, and M. Crabeel, J. Biol. Chem., 276, 42869–42880 (2001).

    Article  PubMed  CAS  Google Scholar 

The arginine repressor

Aminoadipic acid pathway

  • J. K. Bhattacharjee, Crit. Rev. Microbiol., 12, 131–51 (1985).

    CAS  Google Scholar 

  • A. Feller, F. Ramos, A. Piérard and E. Dubois, Eur. J. Biochem., 261, 163–70 (1999).

    Article  PubMed  CAS  Google Scholar 

  • E. Johansson, J. J. Steffens, Y. Lindqvist and G. Schneider, Structure Fold Des, 1037–47 (2000).

    Google Scholar 

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© 2004 Springer Science+Business Media Dordrecht

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Cohen, G.N. (2004). Biosynthesis of the amino acids of the glutamic acid family and its regulation. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2237-1_25

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  • DOI: https://doi.org/10.1007/978-1-4020-2237-1_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6390-8

  • Online ISBN: 978-1-4020-2237-1

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