Positive regulation

  • Georges N. Cohen


It has long been known that the presence of glucose (or of another easily degradable carbon source) inhibits the synthesis of certain bacterial enzymes such as β-galactosidase or tryptophanase from E. coli, or inositol dehydrogenase and histidase from Bacillus subtilis. This phenomenon was called glucose effect. In 1961, Magasanik gave it the more general name of catabolic repression. Many catabolic enzymes being inducible, the rate of their synthesis must then depend on the intracellular concentrations of the inducer and of the catabolite exerting its repressive effect.


Catabolic Enzyme Glucose Effect Catabolic Repression Lactose Operon Degradable Carbon Source 
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Selected references

Catabolic repression

  1. B. Magasanik, Cold Spring Harbor Symp. Quant. Biol., 26, 249–256 (1961).CrossRefGoogle Scholar

Effects of cyclic AMP on the glucose effect

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The promoter

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The CAP protein

  1. D. A. Chambers and G. Zubay, Proc. Natl. Acad. Sci. U. S., 63, 118–122 (1969).CrossRefGoogle Scholar
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Mode of action of cyclic AMP

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  2. N. D. Meadow, D. K. Fox and S. Roseman, Ann. Rev. Biochem., 59, 497–542 (1990).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Georges N. Cohen
    • 1
    • 2
  1. 1.Centre National de la Recherche ScientifiqueParisFrance
  2. 2.Institut PasteurParisFrance

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