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Positive regulation

  • Georges N. Cohen

Abstract

It has long been known that the presence of glucose (or of another easily degradable carbon source) inhibits the synthesis of certain bacterial enzymes such as β-galactosidase or tryptophanase from E. coli, or inositol dehydrogenase and histidase from Bacillus subtilis. This phenomenon was called glucose effect. In 1961, Magasanik gave it the more general name of catabolic repression. Many catabolic enzymes being inducible, the rate of their synthesis must then depend on the intracellular concentrations of the inducer and of the catabolite exerting its repressive effect.

Keywords

Catabolic Enzyme Glucose Effect Catabolic Repression Lactose Operon Degradable Carbon Source 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Selected references

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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Georges N. Cohen
    • 1
    • 2
  1. 1.Centre National de la Recherche ScientifiqueParisFrance
  2. 2.Institut PasteurParisFrance

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