It has long been known that the presence of glucose (or of another easily degradable carbon source) inhibits the synthesis of certain bacterial enzymes such as β-galactosidase or tryptophanase from E. coli, or inositol dehydrogenase and histidase from Bacillus subtilis. This phenomenon was called glucose effect. In 1961, Magasanik gave it the more general name of catabolic repression. Many catabolic enzymes being inducible, the rate of their synthesis must then depend on the intracellular concentrations of the inducer and of the catabolite exerting its repressive effect.
KeywordsSugar Glycerol Adenosine Adduct Bacillus
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Effects of cyclic AMP on the glucose effect
- F. Jacob, A. Ullman et J. Monod, Comptes rendus, 258, 3125–3128 (1964).Google Scholar