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Quantitation of Bone Metastasis in Experimental Systems

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Bone Metastasis and Molecular Mechanisms

Part of the book series: Cancer Metastasis — Biology and Treatment ((CMBT,volume 6))

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Abstract

Animal models are important tools to investigate the pathogenesis and develop treatment strategies for bone metastases in humans. However, there are few spontaneous models of bone metastasis despite the fact that rodents (rats and mice) and other animals (dogs and cats) often spontaneously develop cancer. Therefore, most experimental models of bone metastasis in rodents require injection or implantation of neoplastic cells into orthotopic locations, bones, or the left ventricle of the heart.

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Author information

Authors and Affiliations

  1. Department of Surgery, St. Vincent’s Institute of Medical Research, University of Melbourne, Fitzroy, Australia

    Julie A. Sharp & Erik W. Thompson

  2. Bernard O’Brien Institute of Microsurgery, St. Vincent’s Hospital, Fitzroy, Australia

    Erik W. Thompson

Authors
  1. Julie A. Sharp
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  2. Erik W. Thompson
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Editor information

Editors and Affiliations

  1. Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada

    Gurmit Singh (Director of Research, Professor of Pathology & Molecular Medicine) (Director of Research, Professor of Pathology & Molecular Medicine)

  2. Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada

    William Orr (Chair) (Chair)

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© 2004 Springer Science+Business Media Dordrecht

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Sharp, J.A., Thompson, E.W. (2004). Quantitation of Bone Metastasis in Experimental Systems. In: Singh, G., Orr, W. (eds) Bone Metastasis and Molecular Mechanisms. Cancer Metastasis — Biology and Treatment, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2036-0_2

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  • DOI: https://doi.org/10.1007/978-1-4020-2036-0_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6563-6

  • Online ISBN: 978-1-4020-2036-0

  • eBook Packages: Springer Book Archive

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