Abstract
The suggestion of a link between nutrition and multiple sclerosis arose from epidemiological studies which described a high incidence in countries with relatively high saturated fat intakes: in addition, low levels of essential fatty acids (EFA) were recorded in the blood of multiple sclerosis patients (Swank, 1950: Sinclair, 1956: Allison, 1963; Bernsohn and Stephanides, 1976: Dick, 1976). These findings led to a double-blind trial of linoleic acid supplementation in Belfast and London and later in Newcastle (Millar et al, 1973; Bates et al, 1978) which gave encouraging results. The ‘linoleic acid’ effect is the reason for the current interest in diet and multiple sclerosis, but it is becoming apparent that a case for nutritional counselling can also be made in the interests of the general health of the patients, and that a broader approach might be of more benefit.
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References
Allison, R. S. (1963). Some neurological aspects of medical geography. Proc. R. Soc. Med. 56, 71–76.
Bates, D., Fawcett, P. R. W., Shaw, D. A. and Weightman, D. (1978). Trail of polyunsaturated fatty acids in non-relapsing multiple sclerosis. Br. med. J. ii, 932–3.
Benolken, R. M., Anderson, R. E. and Wheeler, T. G. (1973). Membrane fatty acids associated with the electrical response in visual excitation. Science, N. Y. 182, 1253–4.
Bergstrom, S., Danielsson, H. and Samuelsson, B. (1964). Enzymatic formation of prostaglandin (PG)E2 from arachi- donic acid PG and related factors 32. Biochem. biophys. Acta 90,207–210.
Bernsohn, J. and Stephanides, L. M. (1976). Aetiology of multiple sclerosis. Nature, Lond. 215, 821–3.
Caldwell, D. F. and Churchill, J. A. (1966). Learning impair ment in rats administered a lipid free diet during pregnancy. Psychol. Rep. 19, 99–102.
Clausen, J. and Moller, J. (1967). Allergic encephalomyelitis induced by brain antigen after deficiency in polyunsatu rated fatty acids during myelination. Acta neuroi scand. 43,375–88.
Crawford, M. A., Budowski, P. and Hassam, A. G. (1979). Dietary management in multiple sclerosis. Proc. Nutr. Soc. 38,373–89.
Crawford, M. A., Casperd, N.M. and Sinclair, A.J. (1976). The long chain metabolites of linoleic acid in liver and brain in herbivores and carnivores. Comp. Biochem. Physiol. 54B, 395–401.
Dick, G. (1976). The etiology of multiple sclerosis. Proc. R. Soc. Med. 69, 611–5.
Dror, Y., Budowski, P., Bubis, J. J., Sandbank, U. and Wolman, M. (1976). Chick nutritional encephalopathy in duced by diet rich in oxidized oil and deficient in tocoph erol. Progr. Neuropath. 3, 343–57.
DHSS (1979). Recommended Daily Amounts of Food Energy and Nutrients for Groups of People in the United Kingdom, Report on Health and Social Subjects no. 15, HMSO, London.
Galli, C, Galli, G., Spagnuolç, C, Bosisio, E., Tosi, I., Folco, G. C. and Longiave, D. (1977). In Function and Biosynthesis of Lipids (Ed. N. G. Bazan, R. R. Brenner and N. M. Giusto), Plenum Press, London, p.561
Hassam, A. G. and Crawford, M. A. (1976). The differential incorporation of labelled linoleic, g. linolenic, dihomo-g- linolenic and arachidonic acids into the developing rat brain.. J. Neurochem. 27,967–8.
Mertin, J. and Stackpoole, A. (1978). Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin. Prostaglandins Med. 1,283–91.
Millar, J. H. D., Zilkha, K. J., Langman, M. J. S., Wright, H. P., Smith, A. D., Belin, J. and Thompson, R. H. S. (1973). Double-blind trial of linoleate supplementation of the diet of multiple sclerosis. Br. med. J. i, 765–8.
Moncada, S., Gzyglewski, R., Bunting, S. and Vane, J. R. (1976). An enzyme isolated from arteries transforms prosta glandin endoperoxides to an unstable substance that in hibits platelet aggregation. Nature, Lond. 263, 663–5.
Selivonchick, D. P. and Johnston, P. V. (1975). Fat deficiency in rats during development of the central nervous system and susceptibility to experimental allergic encephalomye litis. J. Nutr. 105,288–300.
Sinclair, A.J. and Crawford, M. A. (1973). The effect of a low-fat maternal diet in neonatal rats. Br. J. Nutr. 29, 127–37.
Sinclair, H. M. (1956). Letter to the editor: deficiency of essential fatty acids and atherosclerosis. Lancet, i, 381–3.
Sun, G. Y., Go, J. and Sun, A. Y. (1974). Induction of essen tial fatty acid deficiency in mouse brain: effects of fat deficient diet upon acyl group composition of myelin and synaptosone-rich fractions during development and matu ration. Lipids 9, 450–4.
Swank, R. L. (1950). Multiple sclerosis, a correlation of its incidence with dietary fat. Am. J. med. Sei. 220, 421–30.
Van Dorp, D. A., Beerthuis, R. K., Nugteren, D. H. and Vonkeman, H. (1964). Enzymatic conversion of allcis polyunsaturated fatty acids into prostaglandins. Nature, Lond. 203, 839–41.
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Crawford, M.A., Harding, J. (1982). The role of diet in multiple sclerosis. In: Capildeo, R., Maxwell, A. (eds) Progress in Rehabilitation. Palgrave, London. https://doi.org/10.1007/978-1-349-86080-7_8
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DOI: https://doi.org/10.1007/978-1-349-86080-7_8
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