Skip to main content

The role of diet in multiple sclerosis

  • Chapter
Progress in Rehabilitation

Abstract

The suggestion of a link between nutrition and multiple sclerosis arose from epidemiological studies which described a high incidence in countries with relatively high saturated fat intakes: in addition, low levels of essential fatty acids (EFA) were recorded in the blood of multiple sclerosis patients (Swank, 1950: Sinclair, 1956: Allison, 1963; Bernsohn and Stephanides, 1976: Dick, 1976). These findings led to a double-blind trial of linoleic acid supplementation in Belfast and London and later in Newcastle (Millar et al, 1973; Bates et al, 1978) which gave encouraging results. The ‘linoleic acid’ effect is the reason for the current interest in diet and multiple sclerosis, but it is becoming apparent that a case for nutritional counselling can also be made in the interests of the general health of the patients, and that a broader approach might be of more benefit.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allison, R. S. (1963). Some neurological aspects of medical geography. Proc. R. Soc. Med. 56, 71–76.

    Google Scholar 

  • Bates, D., Fawcett, P. R. W., Shaw, D. A. and Weightman, D. (1978). Trail of polyunsaturated fatty acids in non-relapsing multiple sclerosis. Br. med. J. ii, 932–3.

    Google Scholar 

  • Benolken, R. M., Anderson, R. E. and Wheeler, T. G. (1973). Membrane fatty acids associated with the electrical response in visual excitation. Science, N. Y. 182, 1253–4.

    Article  Google Scholar 

  • Bergstrom, S., Danielsson, H. and Samuelsson, B. (1964). Enzymatic formation of prostaglandin (PG)E2 from arachi- donic acid PG and related factors 32. Biochem. biophys. Acta 90,207–210.

    Article  Google Scholar 

  • Bernsohn, J. and Stephanides, L. M. (1976). Aetiology of multiple sclerosis. Nature, Lond. 215, 821–3.

    Article  Google Scholar 

  • Caldwell, D. F. and Churchill, J. A. (1966). Learning impair ment in rats administered a lipid free diet during pregnancy. Psychol. Rep. 19, 99–102.

    Article  Google Scholar 

  • Clausen, J. and Moller, J. (1967). Allergic encephalomyelitis induced by brain antigen after deficiency in polyunsatu rated fatty acids during myelination. Acta neuroi scand. 43,375–88.

    Article  Google Scholar 

  • Crawford, M. A., Budowski, P. and Hassam, A. G. (1979). Dietary management in multiple sclerosis. Proc. Nutr. Soc. 38,373–89.

    Article  Google Scholar 

  • Crawford, M. A., Casperd, N.M. and Sinclair, A.J. (1976). The long chain metabolites of linoleic acid in liver and brain in herbivores and carnivores. Comp. Biochem. Physiol. 54B, 395–401.

    Article  Google Scholar 

  • Dick, G. (1976). The etiology of multiple sclerosis. Proc. R. Soc. Med. 69, 611–5.

    Google Scholar 

  • Dror, Y., Budowski, P., Bubis, J. J., Sandbank, U. and Wolman, M. (1976). Chick nutritional encephalopathy in duced by diet rich in oxidized oil and deficient in tocoph erol. Progr. Neuropath. 3, 343–57.

    Google Scholar 

  • DHSS (1979). Recommended Daily Amounts of Food Energy and Nutrients for Groups of People in the United Kingdom, Report on Health and Social Subjects no. 15, HMSO, London.

    Google Scholar 

  • Galli, C, Galli, G., Spagnuolç, C, Bosisio, E., Tosi, I., Folco, G. C. and Longiave, D. (1977). In Function and Biosynthesis of Lipids (Ed. N. G. Bazan, R. R. Brenner and N. M. Giusto), Plenum Press, London, p.561

    Book  Google Scholar 

  • Hassam, A. G. and Crawford, M. A. (1976). The differential incorporation of labelled linoleic, g. linolenic, dihomo-g- linolenic and arachidonic acids into the developing rat brain.. J. Neurochem. 27,967–8.

    Article  Google Scholar 

  • Mertin, J. and Stackpoole, A. (1978). Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin. Prostaglandins Med. 1,283–91.

    Article  Google Scholar 

  • Millar, J. H. D., Zilkha, K. J., Langman, M. J. S., Wright, H. P., Smith, A. D., Belin, J. and Thompson, R. H. S. (1973). Double-blind trial of linoleate supplementation of the diet of multiple sclerosis. Br. med. J. i, 765–8.

    Google Scholar 

  • Moncada, S., Gzyglewski, R., Bunting, S. and Vane, J. R. (1976). An enzyme isolated from arteries transforms prosta glandin endoperoxides to an unstable substance that in hibits platelet aggregation. Nature, Lond. 263, 663–5.

    Article  Google Scholar 

  • Selivonchick, D. P. and Johnston, P. V. (1975). Fat deficiency in rats during development of the central nervous system and susceptibility to experimental allergic encephalomye litis. J. Nutr. 105,288–300.

    Google Scholar 

  • Sinclair, A.J. and Crawford, M. A. (1973). The effect of a low-fat maternal diet in neonatal rats. Br. J. Nutr. 29, 127–37.

    Article  Google Scholar 

  • Sinclair, H. M. (1956). Letter to the editor: deficiency of essential fatty acids and atherosclerosis. Lancet, i, 381–3.

    Google Scholar 

  • Sun, G. Y., Go, J. and Sun, A. Y. (1974). Induction of essen tial fatty acid deficiency in mouse brain: effects of fat deficient diet upon acyl group composition of myelin and synaptosone-rich fractions during development and matu ration. Lipids 9, 450–4.

    Article  Google Scholar 

  • Swank, R. L. (1950). Multiple sclerosis, a correlation of its incidence with dietary fat. Am. J. med. Sei. 220, 421–30.

    Article  Google Scholar 

  • Van Dorp, D. A., Beerthuis, R. K., Nugteren, D. H. and Vonkeman, H. (1964). Enzymatic conversion of allcis polyunsaturated fatty acids into prostaglandins. Nature, Lond. 203, 839–41.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Copyright information

© 1982 The contributors

About this chapter

Cite this chapter

Crawford, M.A., Harding, J. (1982). The role of diet in multiple sclerosis. In: Capildeo, R., Maxwell, A. (eds) Progress in Rehabilitation. Palgrave, London. https://doi.org/10.1007/978-1-349-86080-7_8

Download citation

Publish with us

Policies and ethics