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Some pharmacological and clinical aspects of reversible MAO inhibitors

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IUPHAR 9th International Congress of Pharmacology

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Abstract

Monoamine oxidase inhibitors (MAOIs) of the first generation are non selective inhibitors, with the exception of clorgyline and l-deprenyl which are selective inhibitors of the A and B forms respectively and can therefore be considered MAOIs of the second generation. The present definition of the two forms of MAO is in fact the following: MAO-A is inhibited by low (around nanomolar) concentrations of clorgyline whereas MAO-B is not inhibited until micromolar concentrations of this inhibitor are used. The reverse is true when the acetylenic inhibitor l-deprenyl is used to inhibit MAO activity.

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  1. Centre de Recherche Delalande, 10 rue des Carrières, 92500, Rueil-Malmaison, France

    M. Strolin Benedetti

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  1. M. Strolin Benedetti
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William Paton James Mitchell Paul Turner

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© 1984 Macmillan Publishers Limited

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Benedetti, M.S. (1984). Some pharmacological and clinical aspects of reversible MAO inhibitors. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-86029-6_32

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