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Endogenous substrates and inhibitors of monoamine oxidase

  • Chapter
IUPHAR 9th International Congress of Pharmacology

Abstract

Monoamine oxidase (MAO) (EC 1.4.3.4) acts on a wide range of endogenous monoamine substrates including the neurotransmitters, noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT) and adrenaline (see Costa & Sandler, 1972), tele-methylhistamine (Elsworth et al, 1980) and the ‘trace amines’, phenylethylamine (PEA), phenyl-ethanolamine, o-, m- and p-tyramine, tryptamine, 5-methoxytryptamine, N-methyltryptamine, di-methyltryptamine and the octopamines (Usdin & Sandler, 1976; Boulton et al, 1984), and the list is by no means complete. Unlike DA, NA and 5-HT, which are present in the rat brain in a concentration of the order of 500 ng g_1, the trace amines are only represented at a level of less than 10 ng g_1, and as yet have no proven role. Although it is possible that they are merely byproducts of metabolism, without biological function, it seems rather more likely that some act in a modulatory fashion in connection with specific neuronal pathways.

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    Authors
    1. M. Sandler
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    2. V. Glover
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    3. J. D. Elsworth
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    William Paton James Mitchell Paul Turner

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    © 1984 Macmillan Publishers Limited

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    Sandler, M., Glover, V., Elsworth, J.D. (1984). Endogenous substrates and inhibitors of monoamine oxidase. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology. Palgrave, London. https://doi.org/10.1007/978-1-349-86029-6_28

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