N.m.r. studies of drug-receptor interactions as an aid to drug design

  • G. C. K. Roberts


The importance of the relation between the structure of drugs and their biological activity has been recognised for almost 300 years (Locke, 1690). With the development of the idea of the receptor at the beginning of this century, the conceptual framework for modern structure-activity analysis was established. Over the ensuing years increasingly sophisticated studies of the relationships between chemical structure, conformation and physicochemical properties on the one hand and biological activity on the other, have made major contributions to the design of new and effective drugs, although for most systems the receptor remained simply an idea.


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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • G. C. K. Roberts
    • 1
  1. 1.Division of Physical BiochemistryNational Institute for Medical ResearchLondonUK

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