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Metabolic Compartmentation in the Brain pp 81–93Cite as

Changes Within Metabolic Compartments Related to the Functional State and the Action of Drugs on the Whole Brain

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Abstract

The evidence for the existence in the whole brain of more than one meta-bolically distinct tricarboxylic acid cycle and the compartmentation of certain amino acids, particularly glutamate, is considered in detail by other contributors (see Bed, Chapter 1; Garfinkel, Chapter 11; Van den Berg, Chapter 12 and Balázs et al., Chapter 13). It is the purpose of this chapter to consider the action of various drugs, metabolic inhibitors and the functional state of the nervous system within the framework of the metabolic models presented by the above mentioned authors. The model of Garfinkel (1970 and Chapter 11) will be referred to mainly since the majority of studies with drugs have been made on rat brain. Although the model of Van den Berg (Chapter 12) and Van den Berg and Garfinkel (1971) for the mouse brain is similar there are quantitative differences.

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Authors
  1. J. E. Cremer
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Editors and Affiliations

  1. Medical Research Council Neuropsychiatry and Toxicology Units, Carshalton, UK

    R. Balázs  & J. E. Cremer  & 

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Cremer, J.E. (1973). Changes Within Metabolic Compartments Related to the Functional State and the Action of Drugs on the Whole Brain. In: Balázs, R., Cremer, J.E. (eds) Metabolic Compartmentation in the Brain. Palgrave, London. https://doi.org/10.1007/978-1-349-81567-8_7

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  • DOI: https://doi.org/10.1007/978-1-349-81567-8_7

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-81569-2

  • Online ISBN: 978-1-349-81567-8

  • eBook Packages: MedicineMedicine (R0)

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