Skip to main content

The Mitochondrion as a Model of Compartmentation

  • Chapter
Metabolic Compartmentation in the Brain

Abstract

The obvious advantages of combining a number of enzymes, catalysing a series of connected or closely related reactions, within one compartment have been realized in a multitude of subcellular organelles. However, not only has the physical separation of such sets of enzymes been put to profitable use, but it is very often found that the membrane surrounding an organelle plays an active role in regulating the movement of the small molecules to be acted upon from one compartment to the other. In this chapter some properties of the mitochondrion as an example of this compartmentation will be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Borst, P. (1963). Funktionelle und Morphologische Organisation der Zelle, p. 137, Ed. by Karlson P. Berlin: Springer.

    Google Scholar 

  • Bruni, A., Luciani, S., and Contessa, A. R. (1964). Nature, 201, 1219–20.

    Article  Google Scholar 

  • Chappell, J. B. (1969). Inhibitors: Tools in Cell Research, Ed. by Bücher, Th. and Sies, H. Heidelberg; Springer.

    Google Scholar 

  • Chappell, J. B., and Robinson, B. H. (1968). Biochem. Soc. Symp., 27, 123–33.

    Google Scholar 

  • Delbrück, A., Zebe, E., and Bücher, Th. (1959). Biochem. Z., 331, 273–96.

    Google Scholar 

  • Devlin, T. M., and Bedell, B. H. (1960). J. Biol. Chem., 235, 2134–9.

    Google Scholar 

  • Grinius, L. L., Jasaitis, A. A., Kadziauskas, J. P., Liberman, E. A., Skulachev, V. P., Topali, V. P., Tsofina, L. M., and Vladimirova, M. A. (1970). Biochim. Biophys. Acta, 216, 1–12.

    Article  Google Scholar 

  • Groot, G. S. P. (1970). Enige aspecten van de mitochondriale energiehuishouding, PhD thesis, University of Amsterdam. Amsterdam: Mondeel-Offsetdrukkerij.

    Google Scholar 

  • Henderson, P. J. F., and Lardy, H. A. (1970). J. Biol. Chem., 245, 1319–26.

    Google Scholar 

  • Jacobs, E. E., and Sanadi, D. R. (1960). J. Biol. Chem., 235, 531–4.

    Google Scholar 

  • Jasaitis, A. A., Kuliene, V. V., and Skulachev, V. P. (1971). Biochim. Biophys. Acta, 234, 177–81.

    Article  Google Scholar 

  • Klingenberg, M. (1970). FEBS Lett., 6, 145–54.

    Article  Google Scholar 

  • Klingenberg, M., and Buchholz, M. (1970). Europ. J. Biochem., 13, 247–52.

    Article  Google Scholar 

  • Klingenberg, M., Grebe, K., and Heldt, H. W. (1970). Biochem. Biophys. Res. Commun., 39, 344–51.

    Article  Google Scholar 

  • Klingenberg, M., Heldt, H. W., and Pfaff, E. (1969). The Energy Level and Metabolic Control in Mitochondria, p. 237, Ed. by Papa, S., Tager, J. M., Quagliariello, E., and Slater, E. C. Bari: Adriatica Editrice.

    Google Scholar 

  • Koundakjian, P. P., and Snoswell, A. M. (1970). Biochem. J., 119, 49–57.

    Article  Google Scholar 

  • Lardy, H. A., and Ferguson, S. M. (1969). Ann. Rev. Biochem., 38, 991–1034.

    Article  Google Scholar 

  • Lee, C. P., and Ernster, L. (1966). Regulation of Metabolic Processes in Mitochondria, 7, p. 218. Ed. by Tager, J. M., Papa, S., Quagliariello, E., and Slater, E. C. BBA Library. Amsterdam: Elsevier.

    Google Scholar 

  • Lehninger, A. L. (1951). J. Biol. Chem., 190, 345–59.

    Google Scholar 

  • Meisner, H., and Klingenberg, M. (1968). J. Biol. Chem., 243, 3631–9.

    Google Scholar 

  • Mitchell, P. (1961). Nature, 191, 144–8.

    Article  Google Scholar 

  • Ohnishi, T., Sottocasa, G. L., and Ernster, L. (1966). Bull. Soc. Chim. Biol., 48, 1189–203.

    Google Scholar 

  • Pfaff, E., Klingenberg, M., and Heldt, H. W. (1965). Biochim. Biophys. Acta, 104, 312–15.

    Article  Google Scholar 

  • Racker, E., Burstein, C., Loyter, A., and Christiansen, R. O. (1970). Electron Transport and Energy Conservation, p. 235, Ed. by Tager, J. M., Papa, S., Quagliariello, E., and Slater, E. C., Bari: Adriatica Editrice.

    Google Scholar 

  • Racker, E., Tyler, D., Estabrook, R. W., Conover, T. W., Parsons, D. F., and Chance, B. (1965). Oxidases and Related Redox Systems, p. 1077. Ed. by King, T. E., Mason, H. S., and Morrison, H., New York: Wiley.

    Google Scholar 

  • Slater, E. C. (1953). Nature, 112, 975–8.

    Article  Google Scholar 

  • Smoly, J. M., and Kuylenstierna, B., Ernster, L. (1970). Proc. Nat. Acad. Sci. US, 66, 125–31.

    Article  Google Scholar 

  • Sottocasa, G. L., Kuylenstierna, B., Ernster, L., and Bergstrand, A. (1967). Methods in Enzymology, X, p. 448. Ed. by Estabrook, R. W., and Pullmann, M. E. New York: Academic Press.

    Google Scholar 

  • Tulp, A., and Van Dam, K. (1969). Biochim. Biophys. Acta, 189, 337–41.

    Article  Google Scholar 

  • Tulp, A., Stam, H., and Van Dam, K. (1971). Biochim. Biophys. Acta., 234, 301–5.

    Article  Google Scholar 

  • Van Dam, K., and Meijer, A. J. (1971). Ann. Rev. Biochem., 40, 115–60.

    Article  Google Scholar 

  • Van den Bergh, S. G., and Slater, E. C. (1962). Biochem. J., 82, 362–71.

    Article  Google Scholar 

  • Vignais, P. V., Vignais, P. M. and Colomb, M. G. (1970). FEBS Lett. 8, 328–32.

    Article  Google Scholar 

  • Weidemann, M. J., Erdelt, H. and Klingenberg, M. (1969). Inhibitors: Tools in Cell Research, p. 324, Ed. by Bücher, Th., and Sies, H. Heidelberg: Springer.

    Chapter  Google Scholar 

  • Weiss, H., Von Jagow, G., Klingenberg, M., and Bücher, Th. (1970). Europ. J. Biochem., 14, 75–82.

    Article  Google Scholar 

  • Wit-Peeters, E. M., Scholte, H. R., and Elenbaas, H. L. (1970). Biochim. Biophys. Acta, 210, 360–70.

    Article  Google Scholar 

  • Wit-Peeters, E. M., Scholte, H. R., Van den Akker, F., and de Nie, I. (1971). Biochim. Biophys. Acta, 231, 23–31.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Copyright information

© 1973 The Contributors

About this chapter

Cite this chapter

Van Dam, K. (1973). The Mitochondrion as a Model of Compartmentation. In: Balázs, R., Cremer, J.E. (eds) Metabolic Compartmentation in the Brain. Palgrave, London. https://doi.org/10.1007/978-1-349-81567-8_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-81567-8_22

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-81569-2

  • Online ISBN: 978-1-349-81567-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics