Patterns of Development and Response of Cultured Mammalian Nerve Tissues

  • M. B. Bornstein
Chapter

Abstract

The history of cultured nerve tissues dates back to 1907, the beginnings of tissue culture, when Harrison (1907) explanted a small fragment of spinal cord obtained from a frog embryo and observed the continuous growth of the axis cylinder out from the neuron cell body and into an area of clotted frog lymph which contained no other cells. This demonstration supplied incontrovertible support for the unitary theory of the neuron and denied the syncytial origin of the axon. During the next 30–40 years, a number of studies examined the cellular aspects of nerve tissues inculture. Attention was directed primarily to the outgrowth zone where individual cells and their cytological characteristics were observable, permitting attempts at identification of neuroglia, microglia and neurons (Hogue, 1947, 1950, 1953; Costero and Pomerat, 1951; Pomerat and Costero, 1956). Murray (1965) has written an excellent, fully documented, detailed account of the many pioneer studies and various technical accomplishments on nervous tissue in vitro.

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  • M. B. Bornstein

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