Abstract
The extensive application of computer simulation to problems of the compartmentation of energy metabolism in the brain is likely to continue. The subject is sufficiently complicated that direct interpretation of results by inspection is at best difficult. Simulation when properly applied is a good illustration of Hamming’s famous dictum: ‘The purpose of computing is insight, not numbers’. Although simulation is still very much of an art, it is nevertheless possible to offer some general instructions for proceeding with such problems, as well as the history of what has already been done with the brain.
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References
Achs, M. J., and Garfinkel, D. (1971). Fed. Proc., 30, 491. Abs.
Balázs, R., Machiyama, Y., Hammond, B. J., Julian, T. and, Richter, D. (1970). Biochem. J., 116, 445–67.
Berl, S., Lajtha, A., and Waelsch, H. (1961). J. Neurochem., 7, 186–97.
Berl, S., Takagaki, G., Clarke, D. D., and Waelsch, H. (1962). J. Biol. Chem., 231, 2562–9.
Berman, M., Shahn, E., and Weiss, M. F. (1962). Biophys. J., 2, 275, 287.
Blockhius, G. D., and Veldstra, H. (1970). FEBS Lett., 11, 197.
Bradford, H. F. (1969). J. Neurochem., 16, 675–84.
Dzubow, L. M., and Garfinkel, D. (1970). Brain Res., 23, 407–17.
Garfinkel, D. (1962). J. Theoret. Biol, 3, 412–22.
Garfinkel, D. (1966). J. Biol. Chem., 241, 3918–29.
Garfinkel, D. (1968). Comput. Biomed. Res., 2, 31–44.
Garfinkel, D. (1970a). Brain Res., 23, 387–406.
Garfinkel, D. (1970b). Progress in Brain Res., 33, 143–54.
Garfinkel, D. (1971). Biochem. Biophys. Res. Commun., 42, 621–6.
Garfinkel, D., and Hess, B. (1964). J. Biol. Chem., 239, 971–83.
Gear, C. W. (1968). Proc. IFIPS Congress, Edinburgh, A81–A90.
Irwin, L., Hollis, J., St. Omer, V., and Ruscha, M. (1971). Abstr. 2nd Meeting, American Society for Neurochemistry, Hershey, Pennsylvania, p. 87.
Kato, T., and Lowry, O. H. (1971). Abstr. 2nd Meeting, American Society for Neurochemistry, Hershey, Pennsylvania, p. 87.
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., and Schulz, D. W. (1964). J. Biol. Chem., 239, 18–30.
Machiyama, Y., Balazs, R., Hammond, B. J., Julian, T., and Richter, D. (1970). Biochem. J., 116,469–81.
Raine, C. S., Poduslo, S. E., and Norton, W. T. (1971). Brain Res., 27, 11–24.
Rose, S. P. R. (1968). J. Neurochem., 15, 1415–29.
Shein, H. M., Britva, A., Hess, H. H., Selkoe, D. J. (1970). Brain Res., 19, 497–501.
Van den Berg, C. J., and Garfinkel, D. (1971). Biochem. J., 123, 211–18.
Van den Berg, C. J., Krzalic, Lj., Mela, P., and Waelsch, H. (1969). Biochem. J., 113, 281–90.
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Garfinkel, D. (1973). Theory and Practice of Computer Simulation as Applied to Compartmentation in Brain. In: Balázs, R., Cremer, J.E. (eds) Metabolic Compartmentation in the Brain. Palgrave, London. https://doi.org/10.1007/978-1-349-81567-8_10
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DOI: https://doi.org/10.1007/978-1-349-81567-8_10
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