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Abstract

Cardiovascular diseases are expected to be the main cause of death globally within the next 15 years owing to the rapidly increasing prevalence in developed countries and Eastern Europe and the rising incidence of obesity and diabetes mellitus.1 Cardiovascular diseases cause 38% of all deaths in North America and are the most common cause of death in European men under 65 and the second most common cause in women.

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References

  1. Gaziano JM. Global burden of cardiovascular disease. In: Braunwald’s Heart Disease (7th edn). Zipes DP, Libby P, Bonow R, Braunwald E (eds). Philadelphia: Elsevier Saunders; 2005: 1.

    Google Scholar 

  2. Brackenridge RDC. In: Medical Selection of Life Risks (2nd ed). Brackenridge RDC (ed). Basingstoke, U.K. Macmillan; 1985: 262.

    Google Scholar 

  3. Cochran Jr. HA, Buck NF. Coronary Artery Disease and other chest pain. A fourth report. Trans Assoc Am Life Insur Med Dir Assoc 1970; 54: 63.

    Google Scholar 

  4. Lew EA. Proceedings 10th International Congress on Life Assurance Medicine. London: Pitman, 1970.

    Google Scholar 

  5. Gill JB et al. Prognostic importance of myocardial ischemia detected by ambulatory monitoring early after acute myocardial infarction. N Engl J Med 1997; 334: 650.

    Google Scholar 

  6. Singer RB. First-year acute coronary event rates in patients with acute myocardial infarction. J Insur Med 1997; 29: 19.

    Article  Google Scholar 

  7. Fessel M. Myocardial infarction in European insureds. J Insur Med 1990; 22: 284.

    Google Scholar 

  8. Strong JP et al. Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathological Determinants of Atherosclerosis in Youth Study. JAMA 1999; 281: 727.

    Article  Google Scholar 

  9. Murabito JM et al. Prognosis after the onset of CHD: an investigation of differences in the outcome between the sexes according to initial coronary disease presentation. Circulation 1993; 88: 2548.

    Article  Google Scholar 

  10. Lerner DJ, Kannel WB. Patterns of CHD morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J 1986; 111:383.

    Article  Google Scholar 

  11. Lampe FC et al. The natural history of prevalent ischaemic heart disease in middle-aged men. Eur Heart J 2000; 21: 1052.

    Article  Google Scholar 

  12. Frank CW, Weinblatt E, Shapiro S. Angina Pectoris in men: prognostic significance of selected medical factors. Circulation 1973; 47: 509.

    Article  Google Scholar 

  13. Deewania PC, Carbajal EV. Silent myocardial ischemia. A clinical perspective. Arch Intern Med 1991; 151:2373.

    Article  Google Scholar 

  14. American Heart Association, Heart and Stroke Facts: 2004 Statistical Supplement. American Heart Association 2004 Dallas, Texas.

    Google Scholar 

  15. Roger VL et al. Time trends in the prevalence of atherosclerosis: a population-based autopsy study. Am J Med 2001; 110:267.

    Article  Google Scholar 

  16. British Heart Foundation 2004. Statistics Fact-sheet. BHF Statistics Database, www.heartstats.org.

  17. Cupples LA et al. Preexisting cardiovascular conditions and long-term prognosis after initial myocardial infarction: The Framingham Study. Am Heart J 1993; 125: 863.

    Article  Google Scholar 

  18. Wilson PWF. Epidemiology and prognosis of CHD. UpToDate 2004; October 8.

    Google Scholar 

  19. Gordon T et al. Menopause and coronary heart disease. The Framingham Study. Ann Intern Med 1978; 89: 157.

    Article  Google Scholar 

  20. Elgin A et al. Secular trends in CVS. Cardiovascular disease mortality, incidence and case fatality rates in adults in the USA. Am J Med 2004; 117:219.

    Article  Google Scholar 

  21. Kuulasmaa K et al. Estimation of contribution of changes in classic risk factors to trends in coronary event rates across the WHO MONICA Project populations. Lancet 2000; 355: 675.

    Article  Google Scholar 

  22. Feinleib M. Trends in heart disease in the United States. Am J Med Sci 1995; 310 (supp 1) S8.

    Article  Google Scholar 

  23. Fox C et al. Temporal Trends in CHD mortality and sudden cardiac death from 1950 to 1999: the Framingham Heart Study. Circulation 2004; 110: 522.

    Article  Google Scholar 

  24. Capewell S et al. Explanation for the decline of CHD mortality rates in Auckland, New Zealand, between 1982 and 1993. Circulation 2000; 102: 1511.

    Article  Google Scholar 

  25. Goldman L. The decline in CHD: determining the paternity of success. Am J Med 2004, 117: 274.

    Article  Google Scholar 

  26. Unal B, Critchley JA, Capewell S. Explaining the decline in CHD mortality in England and Wales between 1981 and 2000. Circulation 2004; 109: 1101.

    Article  Google Scholar 

  27. Levi F et al. Trends in Mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world. Heart 2002; 88: 119.

    Article  Google Scholar 

  28. Reddy KS. Cardiovascular disease in non-western countries. N Eng J Med 2004; 350: 2438.

    Article  Google Scholar 

  29. Critchley J et al. Explaining the increase in CHD mortality in Beijing between 1984 and 1999. Circulation 2004; 110: 1236.

    Article  Google Scholar 

  30. Weissberg PL. Atherogenesis: current understanding of the causes of atheroma. Heart 2000; 83: 247.

    Article  Google Scholar 

  31. Forrester JS. Prevention of plaque rupture: a new paradigm of therapy. Ann Intern Med 2002; 137: 823.

    Article  Google Scholar 

  32. Lerman A, Zeiher AM. Endothelial Function. Circulation 2005; 111: 363.

    Article  Google Scholar 

  33. Glagov S et al. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987; 316: 371.

    Article  Google Scholar 

  34. O’Keefe Jr JH, Lavie CJ, McCallister BD. Insights into the pathogenesis and prevention of coronary artery disease. Mayo Clin Proc 1995; 70: 69.

    Article  Google Scholar 

  35. O’Keefe Jr JH et al. The new paradigm for coronary artery disease: Altering risk factors, atherosclerotic plaques, and clinical prognosis. Mayo Clin Proc 1996; 71: 957.

    Article  Google Scholar 

  36. Giroud D et al. Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography. Am J Cardiol 1992; 69: 729.

    Article  Google Scholar 

  37. Steil GM et al. Impact of compensatory enlargement of atherosclerotic coronary arteries on angiographic assessment of coronary artery disease. Circulation 1989; 80: 1603.

    Article  Google Scholar 

  38. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastin Survival Study (4S). Lancet 1994; 344: 1383.

    Google Scholar 

  39. Shepherd J et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 1995; 333: 1301.

    Article  Google Scholar 

  40. Simoons ML et al. Coronary artery disease: prevention of events. Eur Heart J 1995; 16: 729.

    Google Scholar 

  41. Enos WF, Holmes RH, Beyer J. Coronary disease among U.S. soldiers killed in action in Korea: preliminary report. JAMA 1953; 152: 1090.

    Article  Google Scholar 

  42. Kannel WB et al. Factors of risk in the development of CHD — six year follow-up experience: The Framingham Study. Ann Intern Med 1961; 55: 33.

    Article  Google Scholar 

  43. Wilson PW et al. Prediction of CHD using risk factor categories. Circulation 1998; 97: 1837.

    Article  Google Scholar 

  44. Furberg CD et al. Clinical epidemiology: the conceptual basis of interpreting risk factors. JACC 1996; 27: 976.

    Article  Google Scholar 

  45. Alderman MH. Absolute cardiovascular risk: the basis ofdeciding to treat. Am J Nephrol 1996; 16:182.

    Article  Google Scholar 

  46. Fletcher, R, Fletcher SW, Wagner EH. Clinical Epidemiology (3rd edn). Lippincort, Williams and Wilkins. 1996; 94.

    Google Scholar 

  47. Eisen GM et al. Evaluating risk: a primer for gastroenterologists. AJG 1995; 90: 704.

    Google Scholar 

  48. Jackson R. Guidelines on preventing cardiovascular disease in clinical practice. BMJ 2000; 320: 661.

    Article  Google Scholar 

  49. Sedgewick JEC. Absolute, attributable and relative risk in the management of CHD. Heart 2001; 85: 491.

    Article  Google Scholar 

  50. Franklin SS et al. Hemodynamic patterns of agerelated changes in blood pressure. The Framing-ham Study. Circulation 1997; 96: 308.

    Article  Google Scholar 

  51. Magnus P, Beaglehole R. The real contribution of the major risk factors to the coronary epidemics. Arch Intern Med 2001; 161: 2657.

    Article  Google Scholar 

  52. Greenland P et al. Major risk factors as antecedents of fatal and nonfatal CHD events. JAMA 2003; 290 (7) 891–7.

    Article  Google Scholar 

  53. Khot UN et al. Prevalence of conventional risk factors in patients with CHD. JAMA 2003; 290: 898.

    Article  Google Scholar 

  54. Sesso HD et al. Maternal and parental history of MI and risk of cardiovascular disease in men and women. Circulation 2001; 104: 393.

    Article  Google Scholar 

  55. Scheuner MT. Clinical application of genetic risk assessment strategies for coronary artery disease: genotypes phenotypes and family history. Primary Care 2004; 31: 711.

    Article  Google Scholar 

  56. Hamsten A. Molecular genetics as the rout to understanding, prevention and treatment. Lancet 1996; 348 Suppl 1: S17.

    Article  Google Scholar 

  57. Brown DW et al. Familial aggregation of early-onset MI. Community Genet 2002; 5: 232.

    Article  Google Scholar 

  58. Genest JJ et al. Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation 1992; 85: 2025.

    Article  Google Scholar 

  59. Yusuf S et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART Study): case-control study, Lancet 2004; 364: 937.

    Article  Google Scholar 

  60. Stamler J, Wentworth D, Neaton JD. Is the relationship between serum cholesterol and risk of premature death from CHD continuous and graded? JAMA 1986; 256: 2823.

    Article  Google Scholar 

  61. Otvos JD et al. LDL particles, but not IDL cholesterol, are highly elevated in the metabolic syndrome: results from the Framingham Offspring Study. Circulation 2003; 108 (suppl IV): 740.

    Google Scholar 

  62. Kinosian B, Glick H, Garland G. Cholesterol and CHD: Predicting risk by levels and ratios. Am Intern Med 1994; 121: 641.

    Article  Google Scholar 

  63. Cui Y et al. Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality. Arch Intern Med 2001; 161: 1413.

    Article  Google Scholar 

  64. Sniderman AD, Pedersen T, Kjekshus J. Putting low-density lipoproteins at center stage in athero-genesis. Am J Cardiol 1997; 64.

    Google Scholar 

  65. Lamarche B et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation 1997; 95: 69.

    Article  Google Scholar 

  66. Burt VL et al. Prevalence of hypertension in the USA adult population: Results from NHANES III 1988–91. Hypertension 1995; 25: 305.

    Google Scholar 

  67. Chobanian AV et al. The seventh report of the Joint Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC-7 express). JAMA 2003; 289: 2560.

    Article  Google Scholar 

  68. Pastor-Barriuso R et al. Systolic BP, diastolic BP and pulse pressure: an evaluation of their joint effect on mortality. Ann Int Med 2003; 139: 731.

    Article  Google Scholar 

  69. Franklin SS et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation 1997; 96: 308.

    Article  Google Scholar 

  70. Franklin SS et al. Is pulse pressure useful in predicting risk for CHD? The Framingham Heart Study. Circulation 1999; 100: 354.

    Article  Google Scholar 

  71. Staessen JA et al. Ambulatory pulse pressure as a predictor of outcome in older patients with systolic hypertension. Am J Hypertension 2002; 15: 835.

    Article  Google Scholar 

  72. Domanski M et al. Pulse pressure and cardiovascular disease related mortality: follow-up study of the Multiple Risk Intervention Trial (MRFIT). JAMA 2002; 287: 2677.

    Article  Google Scholar 

  73. Vasan RS et al. Antecedent blood pressure and the risk of cardiovascular disease: The Framingham Heart Study. Circulation 2002; 105: 48.

    Article  Google Scholar 

  74. Pickering TJ et al. How common is white coat hypertension? JAMA 1988; 259: 225.

    Article  Google Scholar 

  75. O’Brien E, Beevers G, Lip GYH. Blood pressure measurement. Part III. Automated sphyngomanometry: Ambulatory blood pressure management. BMJ 2001; 322: 1110.

    Article  Google Scholar 

  76. Vedecchia P. Prognostic value of ambulatory blood pressure. Hypertension 2000; 35: 844.

    Article  Google Scholar 

  77. Neal B, MacMahon S, Chapman N. Effects of ACE inhibitors, calcium antagonists and other blood pressure-lowering drugs. Lancet 2000; 356: 1955.

    Article  Google Scholar 

  78. Wong ND et al. Preventing heart disease by controlling hypertension: impact of hypertensive subtype, stage, age and sex. Am Heart J 2003; 145: 888.

    Article  Google Scholar 

  79. Ruiz-Bailen M et al. Paradoxical effect of smoking in the Spanish population with acute MI or unstable angina. Chest 2004; 125: 831.

    Article  Google Scholar 

  80. Critchley JA, Capewell S. Mortality risk reduction associated with smoking cessation in patients with CHD: a systematic review. JAMA 2003; 290: 86.

    Article  Google Scholar 

  81. Kannel W, McGee D. Diabetes and cardiovascular risk factors: The Framingham Heart Study. Circulation 1979; 59: 8.

    Article  Google Scholar 

  82. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults. Circulation 2002; 106: 3143.

    Google Scholar 

  83. Hoff JA et al. The prevalence of coronary artery calcium among diabetic individuals without known coronary artery disease. J Am Coll Cardiol 2003; 41: 1008.

    Article  Google Scholar 

  84. Kannel W. Lipids, diabetes and CHD: insights from the Framingham Study. Am Heart J 1985; 110: 1100.

    Article  Google Scholar 

  85. Selvin E et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 2004; 141: 421.

    Article  Google Scholar 

  86. Norhammar A et al. Glucose metabolism in patients with acute MI and no previous diagnosis of diabetes mellitus. Lancet 2002; 359: 2140.

    Article  Google Scholar 

  87. Almdal T et al. The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke and death: a population-based study of 13,000 men and women with 20 years of follow-up. Arch Intern Med 2004; 164 1422.

    Article  Google Scholar 

  88. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependant diabetes mellitus. N Engl J Med 1993; 329: 977.

    Article  Google Scholar 

  89. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837.

    Article  Google Scholar 

  90. Kuczmarski RJ et al. Increasing prevalence of overweight among U.S. adults. The NHANES surveys 1960 to 1991. JAMA 1994; 205.

    Google Scholar 

  91. Pouliot MC et al. Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 1994; 73: 400.

    Article  Google Scholar 

  92. Kang SS, Wong PW, Malinow MR. Hyperhomo-cysteinemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 1992; 12: 279.

    Article  Google Scholar 

  93. Jacques PF et al. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 2001; 73: 613.

    Google Scholar 

  94. Stampfer MJ et al. A prospective study of the plasma homocysteine and risk of MI in U.S. physicians. JAMA 1992; 268: 877.

    Article  Google Scholar 

  95. Homocysteine Studies Collaboration. Homocysteine and the risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002; 288: 2015.

    Article  Google Scholar 

  96. Reaven GM. Banting Lecture 1988: Role of insulin resistance in human disease. Diabetes 1988; 37: 1595.

    Article  Google Scholar 

  97. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part I: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539.

    Article  Google Scholar 

  98. Lakka HM et al. The metabolic syndrome and total and cardiovascular mortality in middle-aged men. JAMA 2002; 288: 2709.

    Article  Google Scholar 

  99. Gerstein HC et al. Albuminuria and the risk of cardiovascular events, death and heart failure in diabetic and nondiabetic individuals. JAMA 2001; 286: 421.

    Article  Google Scholar 

  100. Diercks GF et al. Microalbuminuria modifies the mortality risk associated with electrocardiographic ST-T segment changes. J Am Coll Cardiol 2002; 40: 1401.

    Article  Google Scholar 

  101. Danesh J et al. Low grade inflammation and CHD: prospective study and updated meta-analyses. BMJ 2000; 321: 199.

    Article  Google Scholar 

  102. Danesh J et al. C-reactive protein and other circulating markers of inflammation in the prediction of CHD. N Engl J Med 2004; 350: 1387.

    Article  Google Scholar 

  103. Nissen SE et al. Statin therapy, LDL cholesterol; C-reactive protein and coronary artery disease. N Engl J Med 2005; 352: 29.

    Article  Google Scholar 

  104. Ridker PM et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005; 352: 20.

    Article  Google Scholar 

  105. Muntner, P et al. Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. J Am Soc Nephrol 2002; 13: 745.

    Google Scholar 

  106. Lowe LP et al. Impact of major cardiovascular disease risk factors, particularly in combination on 22 year mortality in women and men. Arch Intern Med 1998; 158: 2007.

    Article  Google Scholar 

  107. Stamler J et al. Low risk factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adults and middle-aged men and women. JAMA 1999; 282: 2012.

    Article  Google Scholar 

  108. Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating risk of acute coronary events based on the 10 year follow-up of the prospective Munster (PROCAM) study. Circulation 2002; 105: 310.

    Article  Google Scholar 

  109. Conroy RM et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 2003; 24: 987.

    Article  Google Scholar 

  110. Greenland P, Smith SC, Grundy SM. Improving CHD risk assessment in asymptomatic people. Circulation 2001; 104: 1863.

    Article  Google Scholar 

  111. Garber AM, Hlatky. Stress testing for the diagnosis of CHD. UptoDate 2004; May.

    Google Scholar 

  112. Garber AM, Solomon NA. Cost-effectiveness of alternative test strategies for the diagnosis of coronary artery disease. Ann Int Med 1999; 130: 719.

    Article  Google Scholar 

  113. Gianrossi R et al. Exercise-induced ST depression in the diagnosis of coronary artery disease: a metaanalysis. Circulation 1989; 80: 87.

    Article  Google Scholar 

  114. Kwok T et al. Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol 1999; 83: 660.

    Article  Google Scholar 

  115. Chaitman BR. Exercise Stress Testing. In: Braunwald’s Heart Disease 7th edn. Zipes D, Libby P, Bonow RO, Braunwald E (eds) Philadelphia. Elsevier Saunders 2005; 153–178.

    Google Scholar 

  116. Marwick TH, Cain P. Screening for coronary artery disease. MCNA 1999; 83: 1375.

    Article  Google Scholar 

  117. Mark DB et al. Exercise treadmill score for predicting prognosis in CHD. Ann Int Med 1987; 106: 793.

    Article  Google Scholar 

  118. Greenland P, Gaziano JM. Selecting asymptomatic patients for coronary computed tomography or electrocardiographic exercise testing. N Eng J Med 2003; 349: 465.

    Article  Google Scholar 

  119. Berman DS et al. Nuclear Cardiology. In: Hurst’s The Heart 11th edn. Fuster V, Alexander RW, O’Rourke RA (eds). New York. McGraw-Hill. 2004; 563–598.

    Google Scholar 

  120. Yusuf S et al. Effect of coronary bypass graft surgery on survival: overview of 10-year results from randomized trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration. Lancet 1994; 344: 563.

    Article  Google Scholar 

  121. Senior R et al. Stress echocardiography for the diagnosis and risk stratification of patients with suspected or known coronary artery disease: a critical appraisal. Heart 2005; 91: 427.

    Article  Google Scholar 

  122. Marwick TH. Stress echocardiography. Heart 2003; 89: 113.

    Article  Google Scholar 

  123. Rumberger TH. Electron beam (ultrafast) computed tomography for the evaluation of cardiac disease and function. UpToDate. January 2005.

    Google Scholar 

  124. Mahmarian JJ, Computed Tomography of the heart. In. Hurst’s The Heart 11th edn. Fuster V, Alexander RW, O’Rourke RA (eds). New York. McGraw-Hill. 2004; 599.

    Google Scholar 

  125. Salazar HD, Raggi P. Usefulness of electron-beam computed tomography. Am J Cardiol 2002; 89 (suppl); 17B.

    Article  Google Scholar 

  126. Wexler L et al. Coronary artery calcification: pathophysiology, epidemiology, imaging methods and clinical implications. Circulation 1996; 94: 1175.

    Article  Google Scholar 

  127. Rumberger JA et al. Electron-beam computed tomographic scanning: a review and guidelines for use in asymptomatic persons. Mayo Clin Proc 1999; 74: 243.

    Article  Google Scholar 

  128. Underwood II DG. A scheme for more complete evaluations of exercise electrocardiograms. J Insur Med 1988; 20: 61.

    Google Scholar 

  129. Antman EM, Braunwald E. ST-Elevation MI: pathology, pathophysiology and clinical features. In: Braunwald’s Heart Disease 7th edn. Zipes DP, Libby P, Bonow R, Braunwald E (eds). Philadelphia: Elsevier Saunders: 2005; 1152.

    Google Scholar 

  130. Smith LR et al. Determinants of early versus late cardiac death in patients undergoing coronary bypass graft surgery. Circulation 1991; 84 (supp III); 245.

    Google Scholar 

  131. Campeau L. Grading of angina pectoris. Circulation 1975; 54: 522.

    Google Scholar 

  132. Diamond GA, Forrester JS. Analysis of probability as an aid in the clinical diagnosis of coronary artery disease. N Engl J Med 1979; 300: 1350.

    Article  Google Scholar 

  133. Weiner DA et al. Long-term prognostic value of exercise testing in men and women from the Coronary Artery Surgery Study (CASS) registry. Am J Cardiol 1995; 75: 865.

    Article  Google Scholar 

  134. Gibbons RJ et al ACC/AHA guideline update for the management of stable angina pectoris. (Available at www.acc.org/clinical/guidelines/stable/stable.pdf).

  135. Rosenson RS, Kennedy HL. Calcium channel blockers in acute myocardial infarction. UpToDate September 2004.

    Google Scholar 

  136. Pinkham CA, Titcomb C. Lincoln Re’s coronary artery disease experience study. Lincoln Re’s Medical Resource 1998; 10: 3.

    Google Scholar 

  137. Morrow DA, Gersh BJ, Braunwold E. Chronic coronary artery disease. In: Braunwald’s Heart Disease 7th edn. Zipes DP, Libbey P, Bonow R, Braunwald E (eds). Philadelphia: Elsevier Saunders: 2005; 1281.

    Google Scholar 

  138. Levin T, Arvesty JM. Medical versus interventional therapy in the management of stable angina. UpToDate 1994; June.

    Google Scholar 

  139. The BARI Investigators: seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol 2000; 35: 122.

    Google Scholar 

  140. Prinzmetal M et al. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am J Med 1959; 27: 375.

    Article  Google Scholar 

  141. Delhanty JM. Variant Angina. UpToDate 2004; April.

    Google Scholar 

  142. Walling, A et al. Long-term prognosis of patients with variant angina. Circulation 1987; 76: 990.

    Article  Google Scholar 

  143. Bugiardini R, Merz CNB. Angina with ‘normal’ coronaries. A changing philosophy. JAMA 2005; 293: 477.

    Article  Google Scholar 

  144. Crea F, Lauza GA. Angina pectoris and normal caoronary arteries: cardiac syndrome X. Heart 2004; 90: 457.

    Article  Google Scholar 

  145. Nallamothu N, Iskandrian AE. Myocardial bridging of the coronary arteries. UpToDate 2004; December.

    Google Scholar 

  146. Tzivoni D et al. Prognostic significance of ischemic episodes in patients with previous myocardial infarction. Am J Cardiol 1988; 62: 661.

    Article  Google Scholar 

  147. Cohn PF, Fox KM. Silent myocardial ischemia. Circulation 2003; 108: 1263.

    Article  Google Scholar 

  148. Deedwania PC. Silent myocardial ischemia: epidemiology and pathogenesis. UpToDate July 2004.

    Google Scholar 

  149. Mulcahy D et al. Ischemia during ambulatory monitoring as a prognostic indicator in patients with stable coronary artery disease. JAMA 1997; 277: 318.

    Article  Google Scholar 

  150. O’Rourke RA. Unstable angina and non-ST elevation MI: clinical presentation, diagnostic evaluation, and medical management. In: Hurst’s The Heart 11th edn. Fuster V, Alexander RW, O’Rourke RA (eds). New York. McGraw-Hill. 2004; 1252.

    Google Scholar 

  151. Kim M, Kini AS, Fuster V. Definitions of acute coronary syndromes. In: Hurst’s The Heart 11th edn. Fuster V, Alexander RW, O’Rourke RA (eds). New York. McGraw-Hill. 2004; 215.

    Google Scholar 

  152. Hasdai D et al. A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin. The Euro Heart Survey of Acute Coronary Syndromes (Euro Heart Survey ACS). Eur Heart J 2002; 23:1190.

    Article  Google Scholar 

  153. Fox KA et al. Management of acute coronary syndromes. Variations in practice and outcome. Findings from the Global Registry of Acute Coronary Events (GRACE). Eur Heart J 2002; 23: 1177.

    Article  Google Scholar 

  154. Reeder GS, Kennedy HL. Diagnosis of acute myocardial infarction. UpToDate 2004; August.

    Google Scholar 

  155. Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature. Circulation 1979; 59: 607.

    Article  Google Scholar 

  156. Myocardial infarction redefined — a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000; 36: 959.

    Google Scholar 

  157. Boersma H et al. Estimated gains in life expectancy. A simple tool to select optimal reperfusion treatment in individual patients with evolving myocardial infarction. Eur Heart J 1996; 17 (1): 64–75.

    Article  Google Scholar 

  158. Morrow DA et al. Application of the TIMI risk score for ST-elevation MI in the National Registry of Myocardial Infarction 3. JAMA 2001; 286: 1356.

    Article  Google Scholar 

  159. Fibrinolytic Therapy Trialists (FTT) Collaborative Group: Indications for fibrinolytic therapy in suspected acute MI: collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients. Lancet 1994; 343: 311.

    Google Scholar 

  160. Marchioli R et al. Assessment of absolute risk of death after myocardial infarction by use of multiple-risk-factor assessment equations: GISSI-Prevenzione mortality risk chart. Eur Heart J 2001; 22: 2085.

    Article  Google Scholar 

  161. Rosamond WD et al. Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994. N Engl J Med 1998; 339: 861.

    Article  Google Scholar 

  162. Rogers WJ et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the USA from 1990 through 1999: the National Registry of Myocardial Infarction 1, 2 and 3. J Am Coll Cardiol 2000; 36: 2056.

    Article  Google Scholar 

  163. Guidry UC et al. Temporal trends in event rates after Q-wave myocardial infarction: The Fra-mingham Heart Study. Circulation 1999; 100: 2054.

    Article  Google Scholar 

  164. Simons M. Classification of unstable angina and non-ST elevation MI. UpToDate December 2004.

    Google Scholar 

  165. Cannon CP, Braunwald E. Unstable angina and non-ST elevation MI. In: Braunwald’s Heart Disease 7th edn. Zipes DP, Libby P, Bonow R, Braunwald E (eds). Philadelphia: Elsevier Saunders: 2005; 1243.

    Google Scholar 

  166. French JK, White HD. Clinical implications of the new definition of MI. Heart 2004; 90: 99.

    Article  Google Scholar 

  167. Fox KA et al. British Cardiac Society Working Group on the definition of MI. Heart 2004; 90:603.

    Article  Google Scholar 

  168. Antman EM et al. The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA 2000; 284: 835.

    Article  Google Scholar 

  169. Fox KA. Management of acute coronary syndromes. Heart 2004; 90: 698.

    Article  Google Scholar 

  170. Naslafkih A et al. Geographical variations in post myocardial infarction mortality and their impact on risk selection. J Insur Med 2004; 36: 282.

    Google Scholar 

  171. Hu FB et al. Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. N Engl J Med 2000; 343: 530.

    Article  Google Scholar 

  172. Douglas PS. Determinants and management of cardiovascular risk in women. UpToDate 2004; December.

    Google Scholar 

  173. Martin KA, Rosen HN, Rosenson RS. Postmenopausal hormone therapy and cardiovascular risk. UpToDate 2004; October.

    Google Scholar 

  174. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002; 288: 321.

    Google Scholar 

  175. Hulley S et al., for the Heart and Estrogen/Progestin Replacement Study (HERS) Research Group. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998; 280: 605.

    Article  Google Scholar 

  176. Grady D et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA 2002; 288: 49.

    Article  Google Scholar 

  177. Herrington DM et al. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. N Engl J Med 2000; 343: 522.

    Article  Google Scholar 

  178. Weiner DA et al. Exercise stress testing. Correlations among history of angina, ST- segment response and prevalence of coronary-artery disease in the Coronary Artery Surgery Study (CASS). N Engl J Med 1979; 301: 230.

    Article  Google Scholar 

  179. Kannel WB, Abbott RD. Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N Engl J Med 1984; 311: 1144.

    Article  Google Scholar 

  180. Azar RR, Waters DD. CHD and MI in young men and women. UpToDate 2004; December.

    Google Scholar 

  181. Zimmerman FH, Cameron A, Fisher LD, NG G. Myocardial infarction in young adults: angiographic characterization, risk factors and prognosis (Coronary Artery Surgery Study Registry). J Am Coll Cardiol 1995; 26: 654.

    Article  Google Scholar 

  182. Wolfe MW, Vacek JL. Myocardial infarction in the young. Angiographic features and risk factor analysis of patients with myocardial infarction at or before the age of 35 years. Chest 1988; 94: 926.

    Article  Google Scholar 

  183. Psaty BM et al. Traditional risk factors and subclinical disease measures as predictors of first myocardial infarction in older adults. Arch Intern Med 1999; 159: 1339.

    Article  Google Scholar 

  184. Otto CM et al. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med 1999; 341: 142.

    Article  Google Scholar 

  185. Gersh BJ et al. Comparison of coronary artery bypass surgery and medical therapy in patients 65 years of age or older. A nonrandomized study from the Coronary Artery Surgery Study (CASS) registry. N Engl J Med 1985; 313: 217.

    Article  Google Scholar 

  186. Batchelor WB et al. Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions: results in 7472 octogenarians. National Cardiovascular Network Collaboration. J Am Coll Cardiol 2000; 36: 723.

    Article  Google Scholar 

  187. Medical Impairment Study 1983. Vol 1. Boston: Society of Actuaries and Association of Life Insurance Medical Directors of America, 1986.

    Google Scholar 

  188. Shaper AG et al. Heart rate, ischemic heart disease, and sudden cardiac death in middle aged British men. Br Heart J 1993; 70: 49–55.

    Article  Google Scholar 

  189. Kristal-Boneh E et al. The association of resting heart rate with cardiovascular, cancer and all cause mortality. The Cordis Study. Eur Heart J2000; 21: 116–24.

    Article  Google Scholar 

  190. Malik M, Camm AJ. Editorial. Heart rate variability and clinical cardiology. Br Heart J 1994; 71: 3–6.

    Article  Google Scholar 

  191. Kleiger RE et al. For the multicentre post infarction research group. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987; 59: 256–62.

    Article  Google Scholar 

  192. Sajadieh Ahmad et al. Increased heart rate and reduced heart — rate variability are associated with sub clinical inflammation in middle-aged and elderly subjects with no apparent heart disease. Eur Heart J 2004; 25; 363–70.

    Article  Google Scholar 

  193. Rodstein M, Wooloch I, Gobnor RS. A mortality study of the significance of extrasystoles in an insured population. Trans Assoc Life Insur Med Dir Am 1970; 54: 81–91.

    Google Scholar 

  194. Kennedy HL et al. Long-term follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopics. N Engl J Med 1985; 312: 193–4.

    Article  Google Scholar 

  195. Fleg JL, Kennedy HL. Long-term prognostic significance of ambulatory electrocardiographic findings in apparently healthy subjects greater than or equal to 60 years of age. Am J Cardiol 1992; 70(7): 748–51.

    Article  Google Scholar 

  196. Bikkina M, Larst on MG, Levy D. Prognostic implications of asymptomatic ventricular arrhythmias: the Framingham heart study. Ann Intern Med 1992; 117(12): 990–6.

    Article  Google Scholar 

  197. Duddleston DN. Frequent ventricular contractions. Case study. J Insure Med 2000; 32; 262–5.

    Google Scholar 

  198. Ganz LI, Freedman PL. Medical progress: supraventricular tachycardia. N Engl J Med 1995; 332: 162–71.

    Article  Google Scholar 

  199. Chue CD, Routledge HC, Ahmad RA. Supraventricular tachycardia and elevated troponin in the absence of coronary artery disease. Heart 2004; 90: 3.

    Article  Google Scholar 

  200. Steinberg JS, Atrial fibrillation; an emerging epidemic? Heart 2004; 90: 239–40.

    Article  Google Scholar 

  201. Furberg CD et al. Prevalence of atrial fibrillation in elderly subjects. Am J Cardiol 1994; 74: 236–41.

    Article  Google Scholar 

  202. Stewart S et al. Population prevalence, incidence and predictors of atrial fibrillation in the Renfrew/Paisley study. Heart 2001; 86: 516–21.

    Article  Google Scholar 

  203. Markides V, Schilling RJ. Atrial fibrillation: classification, pathophysiology mechanisms and drug treatment. Heart 2003: 89: 939–43.

    Article  Google Scholar 

  204. Page RL. Newly diagnosed atrial fibrillation. N Engl J Med 2004; 351: 2408–16.

    Article  Google Scholar 

  205. 1979 Atrial Fibrillation Mortality Study. New York: Association of Life Insurance Medical Directors of America/Society of Actuaries.

    Google Scholar 

  206. Krahn AD et al. The natural history of atrial fibrillation: incidence, risk factors, and prognosis in the Manitoba follow-up study. Am J Med 1995; 98: 476–84.

    Article  Google Scholar 

  207. Iacovino JR. Mortality of atrial fibrillation in a population selected to be free of major cardiovascular impairments. J Insure Med 1999; 31: 8–12.

    Google Scholar 

  208. Epstein AE, Corley SD. The NHLBI AFFIRM Investigators. Relationship between sinus rhythm, treatment and survival in the atrial fibrillation follow up investigation of rhythm management (AFFIRM) study (abstract). Circulation 2003; 108: IV–472.

    Google Scholar 

  209. Jais P et al. Catheter ablation for atrial fibrillation. Heart: 2003; 91: 7–9.

    Article  Google Scholar 

  210. Morgan JM, Patients with ventricular arrhythmias: who should be referred to an electrophysiologist? Heart 2002; 88: 544–50.

    Article  Google Scholar 

  211. Katritsis DG, Camm A J. Non sustained ventricular tachycardia: where do we stand? Eur Heart J 2004; 25: 1093–9.

    Article  Google Scholar 

  212. Lew EA, Gajewski J (eds). Medical Risks: trends and mortality by age and time elapsed. Vol 1 and 2. New York: Praeger, 1990.

    Google Scholar 

  213. Shen WK, Hammill SC, Hayes DL. Mixed outlook for long-term survival after permanent pacemaker implantation. Cardiol Review 1994; 12: 7, 13–17.

    Google Scholar 

  214. 1951 Impairment Study. New York: Society of Actuaries, 1954.

    Google Scholar 

  215. Treasure T et al. The evidence for cardio thoracic surgery. TFM Publishing Ltd 2005.

    Google Scholar 

  216. Keogh BE, Kingsman R. Fifth National adult cardiac surgical database report 2003. The Society of Cardio Thoracic Surgeons of Great Britain and Ireland 2004.

    Google Scholar 

  217. Lembo NJ et al. Bedside diagnosis of systolic murmurs. N Engl J Med 1988; 318: 1572–8.

    Article  Google Scholar 

  218. Popp RL. Medical progress. Echocardiography. N Engl J Med 1990; 323: 101–9, 165–72.

    Article  Google Scholar 

  219. Houston AB. Doppler ultrasound and the apparently normal heart. Br Heart J 1993; 69: 99–100.

    Article  Google Scholar 

  220. Joshua AM, Celermjaer DA, Stockier MR. Beauty is in the eye of the examiner; reaching an agreement of physical signs and their value. Intern Med J 2005: 35; 178–87.

    Article  Google Scholar 

  221. Prendergrast BD, Banning AP, Hall RJC. Valvular Heart Disease: recommendations for investigation and management. London: Royal College of Physicians, 1996.

    Google Scholar 

  222. Wilkins GT. Editorial. Valvular heart disease: putting guidelines into practice. BMJ 1997; 314: 1428–9.

    Article  Google Scholar 

  223. Bonow RO et al. ACC/AHA guidelines for the management of patients with valvular heart disease. Circulation 1998, 98: 1949–84.

    Article  Google Scholar 

  224. Marcus RH et al. The spectrum of severe rheumatic mitral valve disease in a developing country. Ann Intern Med 1994; 120: 177–83.

    Article  Google Scholar 

  225. Olesen KH. Mitral Stenosis: a follow-up of 351 patients. Copenhagen: Munksgaard, 1955.

    Google Scholar 

  226. Gilchrist AR, Murray-Lyon RM. Edinburgh Med J 1933; 40: 587.

    Google Scholar 

  227. Hammermeisteir KE et al. Prediction of late survival in patients with mitral valve disease from clinical, hemodynamic and quantitative angiographic variables. Circulation 1978; 57: 341–9.

    Article  Google Scholar 

  228. Braunwald E. Valvular heart disease. In: Braun-wald E (ed). Heart Disease — a text book of cardiovascular medicine 5th edn. Philadelphia: WB Saunders Company, 1997.

    Google Scholar 

  229. Ling LH et al. Clinical outcome of mitral regurgitation due to flail leaflets. N Engl J Med 1996; 335: 1417–23.

    Article  Google Scholar 

  230. Enriquez-Sarano MD et al. Quantitative determinants of outcome of asymptomatic mitral regurgitation. N Eng J Med 2005: 352; 9, 875–83.

    Article  Google Scholar 

  231. Freed LA et al. Prevalence and clinical outcome of mitral — valve prolapse. N Eng J Med 1999: 341; 1–7.

    Article  Google Scholar 

  232. Duren ER, Becker AE, Duning AJ. Long-term follow-up of idiopathic mitral valve prolapse in 300 patients. J Am Coll Cardiol 1988; 11: 42–7.

    Article  Google Scholar 

  233. Nishamura RA et al. Echocardiographic documented mitral valve prolapse. Long-term follow-up of 237 patients. N Engl J Med 1985; 313: 1305–9.

    Article  Google Scholar 

  234. Wilken DL, Hickey AJ. Lifetime risk for patients with mitral valve prolapse developing severe valve regurgitation requiring surgery. Circulation 1988; 78: 10–14.

    Article  Google Scholar 

  235. Zuppiroli A et al. Natural history of mitral valve prolapse. Am J Cardiol 1995; 75: 1028–32.

    Article  Google Scholar 

  236. Stoddard MF et al. Exercise induced mitral regurgitation as a predictor of morbid events in subjects with mitral valve prolapse. J Am Coll Cardiol 1995; 25: 693–9.

    Article  Google Scholar 

  237. Hayek E, Gring CN, Griffin BP, Mitral valve prolapse. Lancet 2005: 365; 50–518.

    Google Scholar 

  238. Nair B et al. Cardiovascular findings in self reported healthy elderly. The elite seniors study. Aust N Z J Med 1996; 26: 363–7.

    Article  Google Scholar 

  239. Otto CN et al. Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Eng J Med 1999; 341: 142–14.

    Article  Google Scholar 

  240. Rapperport E. Natural history of aortic and mitral valve disease. Am J Cardiol 1975; 35: 221–7.

    Article  Google Scholar 

  241. Frank S, Johnson A, Ross J. Natural history of valvular aortic stenosis. Br Heart J 1973; 35: 41.

    Article  Google Scholar 

  242. Hancock EW, Fleming PR. Aortic stenosis. QJM 1960; 29: 209.

    Google Scholar 

  243. Chambers J, Aortic Senosis. BMJ 2005; 330: 801–2.

    Article  Google Scholar 

  244. Campbell JM. Life insurance for applicants with heart disease. Trans Ass Med Soc 1958; 29.

    Google Scholar 

  245. Iung B et al. Recommendations on the management of the asymptomatic patient with valvular heart disease. Eur Heart J 2002; 23: 1253–66.

    Article  Google Scholar 

  246. Enriquez-Sarano MD, Tajik A.J. Aortic regurgitation. New Eng J Med 2004; 351; 1539–46.

    Article  Google Scholar 

  247. Singer RB. Comparative mortality in medical treated aortic regurgitation. J Insure Med 2004; 36: 10–15.

    Google Scholar 

  248. Otto CN. Valvular heart disease. 2nd edn. Saunders 2004.

    Google Scholar 

  249. Cohn LH, Edmunds LH. Cardiac surgery in the adult. 2nd edn. Mcgraw-Hill 2003.

    Google Scholar 

  250. Kouchoukos NT et al. Cardiac Surgery 3rd edn. Churchill Livingston 2003.

    Google Scholar 

  251. Steyerberg EW et al. Prophylactic replacement of Bjork-Shiley convexo-concave heart valves: an easy to use tool to a decision making in individual patients. Heart 1996: 76: 264–8.

    Article  Google Scholar 

  252. Piehler JM et al. Reoperation on prosthetic heart valves: patient-specific estimates of in hospital events. J Thorac Cardiovasc Surg 1995; 109: 30–48.

    Article  Google Scholar 

  253. Oxenham H et al. 20 year comparison of a Bjork-Shiley mechanical heart valve with porcine bio-prosthesis. Heart 2003; 89: 715–21.

    Article  Google Scholar 

  254. Iung B et al. A prospective survey of patients with valvular heart disease in Europe; the Europe heart survey on vavular heart disease. Eur Heart J 2003; 24; 1231–43.

    Article  Google Scholar 

  255. Kinsley RH. Valve replacement. Life Insur Med 1980; 6: 185.

    Google Scholar 

  256. Livesey S et al. Cardiac surgery for patients aged 65 and older: a long-term survival analysis. Br Heart J 1988; 60: 480–4.

    Article  Google Scholar 

  257. Monrad ES et al. Time course of regression of left ventricular hypertrophy after aortic valve replacement. Circulation 1988; 77: 1345–55.

    Article  Google Scholar 

  258. Carabello BA et al. Predictors of outcome for aortic valve replacement in patients with aortic regurgitation and left ventricular dysfunction: a change in the measuring stick. J Am Coll Cardiol 1987; 10: 991–7.

    Article  Google Scholar 

  259. Taniguchi K et al. Preoperative left ventricular function: minimal requirement of the successful late results of valve replacement aortic regurgitation. J Am Coll Cardiol 1987; 10: 510–18.

    Article  Google Scholar 

  260. Copeland DJ et al. Long-term follow-up after isolated aortic valve replacement. J Thorac Cardiovasc Surg 1977; 74: 875.

    Google Scholar 

  261. Malm JR, Bale GS. Long term view of patients with prosthetic valves. Trans Assoc Life Insur Med Dir Am 1980; 64: 430.

    Google Scholar 

  262. Robinson JC. J Insur Med 1981; 12: 11.

    Google Scholar 

  263. Czer SC et al. Reduction in sudden late death by concomitant revascularization with aortic valve replacement. J Thorac Cardiovasc Surg 1988; 95: 390–401.

    Google Scholar 

  264. Schofield PM et al. Aortic valve replacement with combined myocardial revascularization. Br Heart J 1989; 62: 915.

    Google Scholar 

  265. Monro JL et al. Cardiac surgery in Wessex. Br Med J 1983; 286: 361–5.

    Article  Google Scholar 

  266. Scully HE. Prognosis in valve replacement. Trans Assoc Life Insur Med Dir Am 1986; 70: 129–34.

    Google Scholar 

  267. Butchart EG. Surgery for heart valve disease. Hospital Update 1990; 16: 963–74.

    Google Scholar 

  268. Edmunds LH et al. Guidelines for reporting morbidity and mortality after cardiac valvular operations. J Thorac Cardiovasc Surg 1988; 96: 351–3.

    Google Scholar 

  269. Bridgewater V. Mortality data in adult cardiac surgery for named surgeons: retrospective examination of prospectively collected data on coronary artery surgery and aortic valve replacement. BMJ 2005; 330: 506–10.

    Article  Google Scholar 

  270. Teply J et al. The ultimate prognosis after valve replacement; an assessment at 20 years. Ann Thorac Surg l981;32: 111–19.

    Google Scholar 

  271. Lindblom D et al. Long term relative survival rates after heart valve replacement. J Am Coll Cardiol 1990; 15: 566–73.

    Article  Google Scholar 

  272. Monro JL. Wessex Cardiac Unit 10 year survival valve replacement procedures. Personal communication.

    Google Scholar 

  273. Croxson RS, Tyler AW. Underwriting aspects of heart valve replacement. 16th International Conference of COINTRA 1989; 241–54.

    Google Scholar 

  274. Cumming GR. Survival after valve replacement. Trans AAIM 1992; 76: 40–55.

    Google Scholar 

  275. MacKenzie BR. Long-term mortality and complicants of Bjork-Shiley spherical-disc valve — a life table analysis. J Insur Med 1992; 24: 128–32.

    Google Scholar 

  276. Ellis LB, Harken DE. Ann Life Insur Med 1977; 3: 149.

    Google Scholar 

  277. Turi ZG et al. Percutaneous balloon v. surgical closed valvuloplasty for mitral stenosis. Circulation 1991; 66: 156–60.

    Google Scholar 

  278. Kirklin JW. Percutaneous balloon v. surgical closed commissurotomy for mitral stenosis. Circulation 1991, 83: 1450–1.

    Article  Google Scholar 

  279. Lau KW, Ding ZP, Hung JS. Percutaneous transvenous mitral commissurotomy versus surgical commissurotomy in the treatment of mitral stenosis. Clin Cardiol 1997; 20: 99–106.

    Article  Google Scholar 

  280. Carabello BA, Crawford FA. Editorial. Therapy for mitral stenosis comes full circle. N Engl J Med 1994; 331: 1014–15.

    Article  Google Scholar 

  281. Shaw TRD, Sutaria N. Prendergast B. Clinical and hemodynamic profiles of young, middle aged and elderly patients with mitral stenosis undergoing mitral balloon valvotomy. Heart 2003; 89: 1430–36.

    Article  Google Scholar 

  282. Fawzy ME et al. Long term clinical and echocardiography results after successful mitral balloon valvotomy and predictors of long term outcome. Eur Heart] 2005; April 8th.

    Google Scholar 

  283. Ellis LB, Harken DE. Closed valvuloplasty for mitral stenosis. A 12 year follow up study of 1571 patients. N Engl J Med 1964; 260: 643.

    Article  Google Scholar 

  284. Cooper GJ, Wright EM, Smith GH. Mitral valve repair: a valuable procedure with good long term results even when performed infrequently. Br Heart J 1991; 66: 156–60.

    Article  Google Scholar 

  285. Singer RB. Valve repair for mitral insufficiency without stenosis. J Insur Med 1988; 20: 21–3.

    Google Scholar 

  286. Lindblom D et al. Long term relative surivival rates after heart valve replacement. J Am Coll Cardiol 1990; 15: 566–73.

    Article  Google Scholar 

  287. Cumming GR. Underwriting the cardiac risk after aortic valve replacement. Trans Assoc Life Insur Med Dir Am 1987; 71: 151–61.

    Google Scholar 

  288. Ungerleider HE, Clark CP. Trans Assoc Life Insur Med Dir Am 1938; 25: 84.

    Google Scholar 

  289. Siber FJ et al. A cardiovascular survey of chest X-ray and nearly five thousand life insurance applicants: normal standards and distribution curves for relative heart diameter. Trans Assoc Life Insur Med Dir Am 1979; 53: 159.

    Google Scholar 

  290. Singer RB et al. Mortality in 4100 insured applicants with ECG and chest X-ray. Trans Assoc Life Insur Med Dir Am 1981; 65: 180.

    Google Scholar 

  291. Ferrer MI. A study of 6,000 chest X-rays obtained for insurance purposes. J Insur Med 1983; 14: 2: 12–14

    Google Scholar 

  292. Iacovino JR. Underwriting left ventricular hypertrophy — a review of the medical literature with an emphasis on mortality and morbidity. J Insur Med 1992; 24: 256–61.

    Google Scholar 

  293. Lao et al. Left ventricular hypertrophy has a greater impact on survival in women than in men. Circulation 1995; 92: 805–10.

    Article  Google Scholar 

  294. Sjogren A. Prognosis of mild heart failure. In: Gill SRW, True C (eds). Proceedings of the 17th International Congress of Life Insurance Medicine 1993; RSM series number 200; 65–71.

    Google Scholar 

  295. Basan RS et al. Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med 1997; 336: 1350–5.

    Article  Google Scholar 

  296. Varela-Roman A et al. Clinical characteristics and prognosis of hospitalized inpatients with heart failure and preserved or reduced left ventricular ejection fraction. Heart 2002; 88: 249–54.

    Article  Google Scholar 

  297. Singer R.B. Insur Med 2000; 32: 254–61.

    Google Scholar 

  298. Huwez FU et al. Age and body surface area related normal upper and lower limits of M-mode echocardiographic measurements and left ventricular volume and mass from infancy to early adulthood. Br Heart J 1994; 72: 276–80.

    Article  Google Scholar 

  299. Popp RL. Medical progress. Echocardiography. N Engl J Med 1990; 323: 101–9, 165–72.

    Article  Google Scholar 

  300. Franck EU, Furthmayr RH. Marfan’s syndrome and other disorders of fibrillin. Editorial. N Engl J Med 1994; 330: 1384–5.

    Article  Google Scholar 

  301. Treasure T. Elective replacement of the aortic root in Marfan’s syndrome. Br Heart J 1993; 69: 101–3.

    Article  Google Scholar 

  302. Finkbohner R et al. Marfan’s syndrome. Long-term survival and complications after aortic aneursym repair. Circulation 1995; 91: 728–33.

    Article  Google Scholar 

  303. Gott VL et al. Aortic root replacement. J Thorac Cardiovasc Surg 1995; 109: 3: 536–45.

    Article  Google Scholar 

  304. Silverman DI et al. Life expectancy in the Marfan’s syndrome. Am J Cardiol 1995; 75: 157–60.

    Article  Google Scholar 

  305. Krause MJ. Marfan syndrome; literature review of mortality studies J Insur Med 2000; 32: 78–88.

    Google Scholar 

  306. Troughton RW, Asher CR, Klein AL. Pericarditis. Lancet 2004; 363: 717–27.

    Article  Google Scholar 

  307. McCaughan BC et al. Early and late results of pericardectomy for constictive pericarditis. J Thorac Cardiovasc Surg 1985; 89: 340–50.

    Google Scholar 

  308. Infective endocarditis mini symposium Heart 2004; 98: 601–19.

    Google Scholar 

  309. Moreillon P, Quey A. Infective endocarditis. Lancet 2004; 363: 139–49.

    Article  Google Scholar 

  310. Pokorski RJ. Long term survival of patients with infective endocarditis. J Insur Med 1998; 30: 76–78.

    Google Scholar 

  311. D’Ambrosio A et al. The fate of acute mycarditis between spontaneous improvement and evolution to dilated cardiomyopathy; a review. Heart 2001; 85: 499–504.

    Article  Google Scholar 

  312. McCarthy RE et al. Long term outcome of fulminant myocarditis as compared with (acute) non fulminant myocarditis. N Eng J Med 2000; 342: 690–5.

    Article  Google Scholar 

  313. McKenna N et al. Prognosis in hypertrophic cardiomyopathy; role of age and clinical electrocardiographic and hemodynamic features. Am J Cardiol 1981; 46: 1532–8.

    Google Scholar 

  314. Goodwin JF. The frontiers of cardiomyopathy. Br Heart J 1982; 48: 1–18.

    Article  Google Scholar 

  315. Shapiro LM, Zezulka A. Hypertrophic cardiomyopathy: a common disease with a good prognosis. 5 year experience of a district general hospital. Br Heart J 1983; 50: 530–3.

    Google Scholar 

  316. Maron BJ et al. Prevalence of hypertrophic cardiomyopathy in an outpatient population referred for echo cardiographic study. Am J Cardiol 1994; 73: 577–80.

    Article  Google Scholar 

  317. Cannan CR et al. Natural history of hypertrophic cardiomyopathy. A population based study, 1976 to 1990. Circulation 1995; 92(9): 2488–95.

    Article  Google Scholar 

  318. TenCate FJ. Prognosis of hypertrophic cardiomyopathy. J Insur Med 1996; 28: 42–5.

    Google Scholar 

  319. Pokorski RJ. Effect of age on mortality experience in patients with hypertrophic cardiomyopathy. J Insur Med 1997; 29: 43–6.

    Google Scholar 

  320. Iacovino JR. The non-mortality of hypertrophic cardiomyopathy in an unselected community diagnosed and treated population. J Insur Med 1996; 28: 51–5.

    Google Scholar 

  321. Watkins H. Multiple genes cause hypertrophic cardiomyopathy. Br Heart J 1994; 72: s4–s9.

    Article  Google Scholar 

  322. Spirito P et al. The management of hypertrophic cardiomyopathy. N Engl J Med 1997; 336: 775–85.

    Article  Google Scholar 

  323. Pokorski R.J. Hypertrophic cardiomyopathy: risk factors for life and living benefits insurance. J Insur Med 2002; 34: 43–60.

    Google Scholar 

  324. Van Driest SL, Maron BJ, Ackerman MJ. From malignant mutations to malignant domains; the continuing search for prognostic significance in the mutant genes causing hypertrophic cardiomyopathy. Heart 2004; 90: 7–8.

    Article  Google Scholar 

  325. Lenarda A Di et al. Changes in mortality in dilated cardiomyopathy. Br Heart J 1994; 72: s41, s46.

    Article  Google Scholar 

  326. Dec GW, Fuster V. Idiopathic dilated cardiomyopathy. N Engl Med 1994; 331: 1564–75.

    Article  Google Scholar 

  327. Sinagra G. Dilated cardiomyopathy and new techniques in the evaluation of myocardial diseases. Presentation 21st congress of the international committee for life, disability and health assurance medicine 2004.

    Google Scholar 

  328. Iacovino J R. Peripartum cardiomyopathy: mortality outcomes. J Insur Med 2001; 33: 165–69.

    Google Scholar 

  329. Kushwaha SS, Fallon JT, Fuster V. Restrictive cardiomyopathy. N Engl J Med 1997; 266: 267–76.

    Article  Google Scholar 

  330. Goldhaber SZ. Pulmonary embolism Lancet 2004; 363: 1295–305.

    Article  Google Scholar 

  331. Mavor GE. Thromboangitis obliterans, clinical and arteriographic findings, with discussion on clinical diagnosis. QJM 1955; 24: 229.

    Google Scholar 

  332. Eastcott HHG. Prognosis in peripheral vascular disease. Trans Assur Med Soc 1965; 77.

    Google Scholar 

  333. Dormundy JA. Natural history of intermittent claudication. Hospital Update 1991; 17: 314–20.

    Google Scholar 

  334. Davey Smith G, Shipley MJ, Rose G. Intermittent claudication, heart disease risk factors and mortality: the Whitehall Study. Circulation 1990; 82: 1925–31.

    Article  Google Scholar 

  335. Sayers RD et al. Critical ischemia of the lower limb: femorodistal bypass in preference to amputation. BMJ 1992; 304: 898.

    Article  Google Scholar 

  336. Cheshire NJW, Wolfe JHN. Critical leg ischemia: amputation or reconstruction. BMJ 1992; 304: 312–14.

    Article  Google Scholar 

  337. Ouriel K. Peripheral arterial disease, Lancet 2001; 358: 1257–64.

    Article  Google Scholar 

  338. Carrell TWG, Wolfe JHN. Non cardiac vascular disease. Heart 2005; 91: 265–70.

    Article  Google Scholar 

  339. Farkouh ME et al. Influence of coronary heart disease on morbidity and mortality after lower extremity revascularisation surgery: a population based study in Olmsted County Minnesota (1970–1987). J Am Coll Cardiol 1994; 24: 1290–6.

    Article  Google Scholar 

  340. Leng GC et al. Use of ankle/brachical pressure index to predict cardiovascular events and death: a cohort study. BMJ 1996; 313: 1440–4.

    Article  Google Scholar 

  341. Pokorski RJ. Ankle/arm blood pressure index: an insurance perspective. J Insur Med 1993; 25: 445–8.

    Google Scholar 

  342. Van der Vliet JA, Boll APM. Abdominal aortic aneurysm. Lancet 1997; 349: 863–6.

    Article  Google Scholar 

  343. Ernst CB. Current therapy for infra-renal aortic aneurysms. N Engl J Med 1997; 336: 59–60.

    Article  Google Scholar 

  344. Cumming MJ, Cumming M E. Endovascular repair of abdominal aortic aneurysms. J Insur Med 2004; 36: 162–6.

    Google Scholar 

  345. Iacovino JR. Outcome of early surgery compared to surveillance in the management of small aortic aneurysms — a comparative mortality analysis. J Insur Med 2003; 35: 150–154.

    Google Scholar 

  346. Pretre R, von Segesser LK. Aortic dissection. Lancet 1997; 349: 1461–3.

    Article  Google Scholar 

  347. Nieminen HP, Jokinen EV, Sairanen, HI. Late Results of Pediatric Cardiac Surgery in Finland: A Population-Based Study With 96% Follow-Up, Circulation 2001; 104: 570–5.

    Article  Google Scholar 

  348. Kouchoukos NT et al. Cardiac Surgery (2 vols) 3rd edn. Churchill Livingston.

    Google Scholar 

  349. Daubeney PFF, Gatzoulis MA, Webb GD. Diagnosis and Management of Adult Congenital Heart Disease. Churchill Livingston.

    Google Scholar 

  350. Murphy JG et al. Long-term outcome after surgical repair of isolated atrial septal defect. Follow up at 27 to 32 years. N Eng J Med 1990; 323: 1645–50.

    Article  Google Scholar 

  351. Morris CD and Menashe VD. 25-year mortality after surgical repair of congenital heart defect in childhood. A population-based cohort study. JAMA 1991; 226: 3447–72.

    Article  Google Scholar 

  352. Singer RB. 1993. Repair of congenital cardiovascular defects. 25–year follow-up. J Insur Med 1993; 25: 5–10.

    Google Scholar 

  353. Moller JH et al. Late results (30–35 years) after operative closure of isolated ventricular septal defect from 1954 to 1960. Am J Cardiol 1991; 68: 1491.

    Article  Google Scholar 

  354. King RM et al. Prognostic factors and surgical treatment of partial atrioventricular canal. Circulation 1986; 74 (suppl I): 1–41 to 1–46.

    Google Scholar 

  355. Bando K et al. Surgical management of complete atrioventricular septal defects. A twenty-year experience. J Thorac Cardiovasc Surg 1995; 110(5): 1543–52.

    Article  Google Scholar 

  356. Wu MH et al. Implication of aneurysmal transformation in silated perimembranous ventricular septal defect. Am J Cardiol 1993; 72: 596–601.

    Article  Google Scholar 

  357. Hayes CJ et al. Second natural history study of congenital heart defects. Results of treatment of patients with pulmonary valvar stenosis. Circulation 1993; 87(2 Suppl):I28–37.

    Google Scholar 

  358. Rhodes LA et al. Long follow-up (to 43 years) of ventricular septal defect with audible aortic regurgitation. Am J Cardiol 1990; 66: 340–5.

    Article  Google Scholar 

  359. Okita Y et al. Long-term results of aortic valvuloplasty for aortic regurgitation associated with ventricular septal defect. J Thorac Cardiovasc Surg 1988; 96: 769–74.

    Google Scholar 

  360. Mavroudis C, Backer CL, Gevitz M. Forty-six years of patient ductus arteriosus division at Children’s Memorial Hospital of Chicago. Standards for comparison. Ann Surg 1994; 220(3): 402–9; discussion 409–10.

    Article  Google Scholar 

  361. Hayes CJ et al. Second natural history study of congenital heart defects. Results of treatment of patients with pulmonary valvar stenosis. Circulation 1993; 87 (2 Suppl): I 28–37.

    Google Scholar 

  362. Kopecky SL et al. Long-term outcome of patients undergoing surgical repair of isolated pulmonary valve stenosis. Follow-up at 20–30 years. Circulation 1988; 78: 1150–6.

    Article  Google Scholar 

  363. Earing MG et al. Forty Years follow up of patients undergoing surgical repair of isolated pulmonary valve stenosis. Circulation 2004; 110 (Suppl III): 651.

    Google Scholar 

  364. Sabet HY et al. Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literative review of 2715 additional cases. Mayo Clin Proc 1999; 74(1): 14–26.

    Article  Google Scholar 

  365. Steinberger J et al. Echocardiographic Diagnosis of Heart Disease in Apparently Healthy Adolescents. Pediatrics 2000; 105: 815–18.

    Article  Google Scholar 

  366. Pachulski RT, Weinberg AL, Chan KL. Aortic aneurysm in patients with functionally normal or minimally stenotic bicuspid aortic valve. Am J Cardiol. 1991; 67(8): 781–2.

    Article  Google Scholar 

  367. Hahn RT et al. Association of aortic Dilatation with regurgitation, stenotic and functionally normal bicuspid aortic valves. Am Coll Cardiol 1992; 19: 283–8.

    Article  Google Scholar 

  368. Ward C. Clinical significance of the bicuspid aortic valve. Heart. 2000; 83(1): 81–5.

    Article  Google Scholar 

  369. Moore P et al. Midterm results of balloon dilation of congenital aortic stenosis: predictors of success. J Am Col Cardio 1996; 27(5): 1257–63.

    Article  Google Scholar 

  370. Moodie DS et al. Long-term follow-up in the unop-erated univentricular heart. Am J Cardiol 1984;53(8): 1124–8.

    Article  Google Scholar 

  371. Driscoll DJ et al. Five- to fifteen-year follow-up after Fontan operation. Circulation 1992; 85: 469–96.

    Article  Google Scholar 

  372. Ammesh NM, Warnes CA. Survival into adulthood of patients with unoperated single ventricle. Am J Cardiol 1996; 77: 5420–45.

    Google Scholar 

  373. Musumeci F et al. Surgical treatment for double-outlet right ventricle at the Brompton Hospital, 1973 to 1986. J Thorac Cardiovasc Surg 1988: 96: 278–87.

    Google Scholar 

  374. Shen WK et al. Sudden death after repair of double-outlet right ventricle. Circulation 1990; 81(1): 128–36.

    Article  Google Scholar 

  375. Gentles TL, Calder AL, Clarkson PM, Neutze JM. Predictors of long-term survival with Ebstein’s anomaly of the tricuspid valve. Am J Cardiol 1992; 69(4): 377–81.

    Article  Google Scholar 

  376. Watson H. Natural history of Ebstein’s anomaly of tricuspid valve in childhood and adolescence. Br Heart J 1974; 36(5): 417–27.

    Article  Google Scholar 

  377. Giuliani ER et al. The clinical features and natural history of Ebstein’s anomaly of the tricuspid valve. Mayo Clin Proc 1979; 54(3): 163–73.

    Google Scholar 

  378. Radford DJ, Graff RF, Neilson GH. Diagnosis and natural history of Ebstein’s anomaly. Br Heart J 1985; 54(5): 517–22.

    Article  Google Scholar 

  379. Hong YM, Moller JH. Ebstein’s anomaly: a long-term study of survival. Am Heart J 1993; 125(5 Pt1): 1419–24.

    Article  Google Scholar 

  380. Hofbeck M et al. Analysis of survival in patients with pulmonic valve atresia and ventricular septal defect. Am J Cardiol 1991; 67(8): 737–43.

    Article  Google Scholar 

  381. Hawkins JA et al. Early and late results in pulmonary atresia and intact ventricular septum. J Thorac Cardiovasc Surg 1990; 100(4): 492–7.

    Google Scholar 

  382. Olin CL et al. Pulmonary atresia: surgical considerations and results in 103 patients undergoing definitive repair. Circulation 1976; 54 (6 Suppl): III 35–40.

    Google Scholar 

  383. Maron BJ et al. Development and progression of left ventricular hypertrophy in children with hypertrophic cardiomyopathy. N Engl J Med 1986; 315(10): 610–14.

    Article  Google Scholar 

  384. Maron BJ et al. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA study. Circulation 1995; 92: 785–9.

    Article  Google Scholar 

  385. Kofflard MJ et al. Prognosis in hypertrophic cardiomyopathy observed in a large clinic population. Am J Cardiol 1993; 72(12): 939–43.

    Article  Google Scholar 

  386. Hecht GM, Panza JA, Maron BJ. Clinical course of middle-aged asymptomatic patients with hypertrophic cardiomyopathy. Am J Cardiol 1992; 69(9): 935–40.

    Article  Google Scholar 

  387. Koga Y, Utaya K, Toshima H. Prognosis in hypertrophic cardiomyopathy. Am Heart J 1984; 108(2): 351–9.

    Article  Google Scholar 

  388. Louie EK, Edwards LC III. Hypertrophic cardiomyopathy. Prog Cardiovasc Dis 1994; 36: 275–308.

    Article  Google Scholar 

  389. Wigle ED et al. Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review. Prog Cardiovasc Dis 1985; 28(1): 1–83.

    Article  Google Scholar 

  390. Maron BJ et al. Prognosis of surgically corrected coarctation of the aorta. A 20-year postoperative appraisal. Circulation 1973; 47(1): 119–26.

    Article  Google Scholar 

  391. Forfang K et al. Late sudden death after surgical correction of coarctation of the aorta. Importance of aneurysm of the ascending aorta. Acta Med Scand 1979; 206(5): 375–9.

    Google Scholar 

  392. Clarkson PM et al. Results of repair of coarctation of the aorta beyond infancy: a 10–28 year follow-up with particular reference to late systemic hypertension. Am J Cardiol 1983; 51(9): 1481–8.

    Article  Google Scholar 

  393. Simon AB, Zlotop AE. Coarctation of the aorta. Longitudinal assessment of operated patients. Circulation 1974; 50(3): 456–74.

    Article  Google Scholar 

  394. Cohen M et al. Coarctation of the aorta. Long-term follow-up and prediction of outcome after surgical correction. Circulation 1989; 80: 840–5.

    Article  Google Scholar 

  395. Murphy JG et al. Long-term outcome in patients undergoing surgical repair of Tetralogy of Fallot. N Engl J Med 1993; 329(9): 593–9.

    Article  Google Scholar 

  396. Moller JH, Anderson RC. 1000 consecutive children with a cardiac malformation with 26– to 37-year follow-up. Am J Cardiol 1992; 70(6): 661–7.

    Article  Google Scholar 

  397. Waien SA et al. Serial follow-up of adults with repaired tetralogy of Fallot. J Am Coll Cardiol 1991; 20(2): 295–300.

    Article  Google Scholar 

  398. Gatzoulis MA et al. Mechanoelectrical Interaction in Tetralogy of Fallot. Circulation 1995; 92: 231–7.

    Article  Google Scholar 

  399. Walsh EP et. Late results in patients with Tetralogy of Fallot repaired during infancy. Circulation 1988; 77: 1062–7.

    Article  Google Scholar 

  400. Turina MI et al. Late functional deterioration after atrial correction for transposition of the great arteries. Circuation 1989; 80(3 Ptl): I 162–7.

    Google Scholar 

  401. Gewillig M et al. Risk factors for arrhythmia and death after Mustard operation for simple transposition of the great arteries. Circulation 1991; 84(5 Suppl): III 187–92.

    Google Scholar 

  402. Trusler GA et al. Results with the Mustard operation in simple transposition of the great arteries 1963–1985. Ann Surg 1987; 206(3): 251–60.

    Article  Google Scholar 

  403. Losay J et al. Late outcome after arterial switch operation for transposition of the great arteries. Circulation. 2001; 104(12 Suppl 1):I 121–6.

    Google Scholar 

  404. Legendre A et al. Coronary events after arterial switch operation for transposition of the great arteries. Circulation. 2003; 108: II-186.

    Article  Google Scholar 

  405. Presbitero P et al. Corrected transposition of the great arteries without associated defects in adult patients: clinical profile and follow-up. Br Heart J 1995; 74: 57–9.

    Article  Google Scholar 

  406. Connelly MS et al. Congenitally corrected transposition of the great arteries in the adult: functional status and complications. J Am Coll Cardiol 1996; 27(5):1238–43.

    Article  Google Scholar 

  407. Fernandes F et al. The role of transesophageal echocardiography in identifying anomalous coronary arteries. Circulation 1993; 88: 2532–40.

    Article  Google Scholar 

  408. Hellenbrand WE et al. Multicenter USA amplatzer patent ductus occlusion device trial. J American Col of Cardiology 2004; 44: 513–19.

    Article  Google Scholar 

  409. Campbell M, Emanuel R. Six cases of congenital complete heart block followed for 34–40 years. Br Heart J 1967; 29: 577–87.

    Article  Google Scholar 

  410. Jaeggi X et al. Outcome of children with natal, neonatal or childhood diagnoses of congenital atrio-ventricular block. F Am Col Cardio 2002; 39: 130–7.

    Article  Google Scholar 

  411. Thambo JB et al. Detrimental ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical pacing. Circulation 2004; 110(25): 3766–72. Epub 2004 Dec 06.

    Article  Google Scholar 

  412. Ross B, Garson A, McNamara D. Factors affecting outcome in children with long QT syndrome. Circulation 1984; 70 (suppl II): II-320.

    Google Scholar 

  413. Swartz PJ. Sudden infant death syndrome. In: Reviews in Perinatal Medicine. Vol 4. New York: Raven Press, 1981.

    Google Scholar 

  414. Moss AJ et al. The long QT syndrome: prospective longitudinal study of 328 families. Circulation 1991; 84: 1136–44.

    Article  Google Scholar 

  415. Garson A Jr, Gillette PL, McNamara DG. Supraventricular tachycardia in children: clinical features, response to treatment and long-term follow-up on 217 patients. J Pediatr 1981; 98: 875–82.

    Article  Google Scholar 

  416. Munger TM et al. A population study of the natural history of Wolff-Parkinson-White syndrome in Olmstead County, Minnesota, 1953–1989. Circulation 1993; 87: 866–73.

    Article  Google Scholar 

  417. Bernd-Dieter Gonska et al. Radiofrequency catheter ablation of right ventricular tachycardia late after repair of congenital heart defects. Circulation 1996; 94: 1902–8.

    Article  Google Scholar 

  418. Lambert V et al. Mid-term results after surgical repair of anomalous origin of the coronary artery. Circulation 1996; 94 (suppl II): II-38 to II-43.

    Google Scholar 

  419. Garson A Jr, McNamara DG. Sudden death in a pediatric cardiology population, 1958 to 1983: relation to prior arrhythmias. J Am Coll Cardiol 1985; 5 (suppl): 134B–7B.

    Article  Google Scholar 

  420. Liberthson RR. Sudden death from cardiac causes in children and young adults. N Engl J Med 1996; 334: 1039–44.

    Article  Google Scholar 

  421. Marsalese DL et al. Marfan’s syndrome: natural history and long-term follow-up of cardiovascular involvement. J Am Coll Cardiol 1989; 14: 422–8.

    Article  Google Scholar 

  422. Shores J et al. Progression of aortic dilatation and the benefit of long-term B-Adrenergic blockade in Marfan’s syndrome. N Engl J Med 1994; 330: 1335–41.

    Article  Google Scholar 

  423. Shime J et al. Congenital heart disease in pregnancy: short and long-term implications. Am J Obstet Gynegol 1987; 156: 313–22.

    Article  Google Scholar 

  424. Nadas AS (ed). Report from the Joint Study on the Natural History of Congenital Heart Defects. Circulation 1977; 56 (suppl I).

    Google Scholar 

  425. Levison ME et al. Characteristics of patients with multiple episodes of bacterial endocarditis. JAMA 1970; 211: 1355–7.

    Article  Google Scholar 

  426. Bisset GS III et al. Clinical spectrum and long-term follow-up of isolated mitral valve prolapse in 119 children. Circulation 1980; 62: 423–9.

    Article  Google Scholar 

  427. Duren DR, Becker AE, Dunning AJ. Long-term follow-up of idiopathic mitral valve prolapse in 300 patients: a prospective study. J Am Coll Cardiol 1988; 11: 42–7.

    Article  Google Scholar 

  428. Kramer HH et al. Malformation patterns in children with congenital heart disease. AM J Dis Child 1987; 141: 789–95.

    Google Scholar 

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MacKenzie, R., Croxson, R.S., Cumming, G.R. (2006). Cardiovascular Disorders. In: Brackenridge, R.D.C., Croxson, R.S., MacKenzie, R. (eds) Brackenridge’s Medical Selection of Life Risks. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-72324-9_21

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