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Physicochemical Principles of Pharmacy pp 401–443Cite as

Drug Interactions and Incompatibilities — a physicochemical viewpoint

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Abstract

This chapter deals with one aspect of the topic of drug interactions, and contains a discussion of the problem from a physicochemical viewpoint. Many drug interactions in vitro are, not surprisingly, readily explained by resorting to the physical chemistry discussed in previous chapters of this book. There is no reason why the same forces and phenomena that operate in vitro cannot explain many of the observed interactions that occur in vivo, although of course the interplay of physicochemical and physiological forces makes simple interpretations a little hazardous. Interactions such as protein binding, whether as a result of hydrophobic or electrostatic interactions, adsorption of drugs onto solids, chelation and complexation all occur in physiological conditions and are predictable to a large degree.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutics, University of Strathclyde, UK

    A. T. Florence

  2. Department of Pharmacy, University of Manchester, UK

    D. Attwood

Authors
  1. A. T. Florence
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  2. D. Attwood
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© 1981 A.T. Florence and D. Attwood

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Florence, A.T., Attwood, D. (1981). Drug Interactions and Incompatibilities — a physicochemical viewpoint. In: Physicochemical Principles of Pharmacy. Palgrave, London. https://doi.org/10.1007/978-1-349-19480-3_10

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