Pharmacological studies on the release and effects of leukotrienes in human and guinea pig lung tissue
The recent discovery that some arachidonic acid metabolites derived from the 5-lipoxygenase pathway are responsible for slow-reacting substance of anaphylaxis (SRS-A) activity has greatly stimulated research in the field of asthma and other allergic diseases (Murphy et al., 1979). In fact these compounds, which were first detected in leucocytes, possess as a common feature a conjugated triene and have been named leukotrienes (Samuelsson &; Hammarström, 1980).
KeywordsPermeability Aspirin CaCl Histamine Prostaglandin
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