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IUPHAR 9th International Congress of Pharmacology London 1984 pp 43–48Cite as

Palgrave Macmillan

Formation and mechanism of action of leukotrienes: enzymatic hydration of leukotriene A4 by human blood cells

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Abstract

Leukotrienes (LT) are lipids formed by cellular metabolism of polyunsaturated acids, particularly arachidonic acid (Corey, 1982; Samuelsson 1983). Biologically active leukotrienes include LTC4 [(5S,6R)-5-hydroxyl-6-(S-glutathionyl)-7,9-trans-11,14-cis-eicosatetraenoic acid] and its metabolites which are chemical constituents of slow reacting substances of anaphylaxis (Murphy et al., 1979; Lewis et al., 1980; Morris et al., 1980; Orning et al., 1980), and LTB4 [(5S,12R)-5,12-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid] which activates leucocytes (Borgeat & Samuelsson, 1979 a,b; Ford-Hutchinson et al., 1980; Rollins et al., 1983) and contracts respiratory smooth muscle (Sirois et al., 1981).

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Authors and Affiliations

  1. Lipids Research, Pharmaceutical Research & Development, The Upjohn Company, 301 Henrietta Street, Kalamazoo, MI, 49007, USA

    F. A. Fitzpatrick, W. F. Liggett & J. E. McGee

Authors
  1. F. A. Fitzpatrick
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  2. W. F. Liggett
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  3. J. E. McGee
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Editor information

William Paton James Mitchell Paul Turner Cheryl Padgham Eileen Ashcroft

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© 1984 Macmillan Publishers Limited

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Fitzpatrick, F.A., Liggett, W.F., McGee, J.E. (1984). Formation and mechanism of action of leukotrienes: enzymatic hydration of leukotriene A4 by human blood cells. In: Paton, W., Mitchell, J., Turner, P., Padgham, C., Ashcroft, E. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17615-1_7

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