Evidence for myocardial salvage in human clinical ischaemia

  • P. G. Hugenholtz
  • J. W. Deckers
  • W. J. van der Giessen
  • P. S. Serruys
  • J. Lubsen


It is generally accepted that ischaemic injury to the myocardium arises from an imbalance between myocardial oxygen supply and demand. When ischaemia is brief, as is usually the case with stable angina, and there is already considerable narrowing in one or more of the coronary arteries, a relative decrease in reserve will manifest itself when demand is suddenly increased as a result of augmented work of the heart. When the decrease in oxygen supply is primary, when coronary flow decreases as a function of increased resistance in the coronary arterial and capillary system, the degree of ischaemia is often more severe. At other times this condition may be brief and transitory, with no residual damage.


Acute Myocardial Infarction Infarct Size Calcium Antagonist Unstable Angina Myocardial Salvage 
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Additional References

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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • P. G. Hugenholtz
    • 1
  • J. W. Deckers
    • 1
  • W. J. van der Giessen
    • 1
  • P. S. Serruys
    • 1
  • J. Lubsen
    • 1
  1. 1.Thoraxcenter, Division of CardiologyUniversity HospitalRotterdamThe Netherlands

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