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Evidence for myocardial salvage in human clinical ischaemia

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IUPHAR 9th International Congress of Pharmacology London 1984

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Abstract

It is generally accepted that ischaemic injury to the myocardium arises from an imbalance between myocardial oxygen supply and demand. When ischaemia is brief, as is usually the case with stable angina, and there is already considerable narrowing in one or more of the coronary arteries, a relative decrease in reserve will manifest itself when demand is suddenly increased as a result of augmented work of the heart. When the decrease in oxygen supply is primary, when coronary flow decreases as a function of increased resistance in the coronary arterial and capillary system, the degree of ischaemia is often more severe. At other times this condition may be brief and transitory, with no residual damage.

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Authors and Affiliations

  1. Thoraxcenter, Division of Cardiology, University Hospital, Rotterdam, The Netherlands

    P. G. Hugenholtz, J. W. Deckers, W. J. van der Giessen, P. S. Serruys & J. Lubsen

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  1. P. G. Hugenholtz
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  2. J. W. Deckers
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  3. W. J. van der Giessen
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  4. P. S. Serruys
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  5. J. Lubsen
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William Paton James Mitchell Paul Turner Cheryl Padgham Eileen Ashcroft

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© 1984 Macmillan Publishers Limited

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Hugenholtz, P.G., Deckers, J.W., van der Giessen, W.J., Serruys, P.S., Lubsen, J. (1984). Evidence for myocardial salvage in human clinical ischaemia. In: Paton, W., Mitchell, J., Turner, P., Padgham, C., Ashcroft, E. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17615-1_38

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