Abstract
During the last 15 years numerous therapeutic agents have been reported to reduce or limit myocardial infarct size in both experimental and clinical studies (Maroko et al., 1971; Maroko & Braunwald, 1973; Kloner & Braunwald, 1980; Rude et al., 1981). However, the interpretation of some of these studies is now open to question and the methods for measuring infarct size subject to criticism (Most et al., 1976; Vogel et al., 1977; Heng et al., 1978; Peter et al., 1978; Opie, 1980; Hearse & Yellon, 1981; Reimer & Jennings, 1982; Chambers et al., 1983). As a consequence, the ability of pharmacological agents to reduce the size of a myocardial infarct has become a highly controversial issue. Much of this controversy relates to the validity of various experimental models and to the relevance of the results to the clinical situation. With this in mind we have developed new methods which conform to certain criteria which we believe should be adopted when studying the effects of drug therapy on infarct size.
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Yellon, D.M., Hearse, D.J., Downey, J.M. (1984). Myocardial salvage by pharmacological interventions. In: Paton, W., Mitchell, J., Turner, P., Padgham, C., Ashcroft, E. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17615-1_37
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DOI: https://doi.org/10.1007/978-1-349-17615-1_37
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