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Mechanism of action of antidepressant drugs given repeatedly: changes in the responses mediated by noradrenaline (α1) and dopamine receptors

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IUPHAR 9th International Congress of Pharmacology London 1984

Abstract

It is well known that antidepressant drugs (AD) have to be administered for about two weeks to elicit a therapeutic effect in patients. On these grounds it may be assumed that repeated administration induces secondary effects which may be directly responsible for the antidepressive effect. Therefore, experiments on animals, treated repeatedly with AD, are of great importance for studying the mechanism of antidepressive action. The present paper compiles the results of our earlier and recent studies on the effects of AD given repeatedly on responses mediated by α1-adrenoceptors and dopamine (DA) receptors.

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Authors and Affiliations

  1. Institute of Pharmaçology, Polish Academy of Sciences, 12 Smctna Street, 31-343, Cracow, Poland

    J. Maj

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  1. J. Maj
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William Paton James Mitchell Paul Turner Cheryl Padgham Eileen Ashcroft

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© 1984 Macmillan Publishers Limited

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Maj, J. (1984). Mechanism of action of antidepressant drugs given repeatedly: changes in the responses mediated by noradrenaline (α1) and dopamine receptors. In: Paton, W., Mitchell, J., Turner, P., Padgham, C., Ashcroft, E. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17615-1_21

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