Prostacyclin and cerebral circulation
Maintenance of a metabolically adequate cerebral blood flow is a remarkable property of the cerebral circulation conditioned by a cascade of intricate interactions of neurohumoral origin and by a complex of interactions between the vessel wall and blood, first of all platelets. Determination of the vessel wall capacity to synthesize prostacyclin (PGI2) and assessment of its highly aggregatory and vasodilator effect on the one hand, and synthesis of thromboxane A2 (TXA2), a prostacyclin antagonist, in platelets on the other, revealed not only a biochemical community of structural and functional organization of two very different systems, but also made it possible to approach, from a new standpoint, the problems of regulation, pathogenesis of disturbances and pharmacological correction of regional circulation (Samuelsson et al., 1978; Moncada &; Vane, 1979).
KeywordsHuman Serum Albumin Basilar Artery Cerebral Circulation Cerebral Vessel Vascular Segment
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