Neurochemical and molecular studies of antidepressant effects in the modelled depression in animals

  • A. V. Valdman
  • V. V. Rozhanets
  • N. A. Avdulov
  • M. M. Kozlovskaya
  • V. P. Poshivalov

Abstract

The molecular basis for the therapeutic effect of tricyclic, as well as atypical antidepressants (AD), is only partly clear. Recent studies have shown that AD exert multiple effects on pre- and postsynaptic mechanisms in the brain. The shift in the emphasis on the mode of action of AD from acute presynaptic effects to delayed postsynaptic, probably receptormediated events and the role of receptor adaptation in the pathogenesis of affective disorders have been repeatedly reviewed during the last few years (Sugrue, 1983).

Keywords

Depression Dopamine Monoamine Tricyclic Sonal 

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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • A. V. Valdman
    • 1
  • V. V. Rozhanets
    • 1
  • N. A. Avdulov
    • 1
  • M. M. Kozlovskaya
    • 1
  • V. P. Poshivalov
    • 1
  1. 1.Institute of Pharmacology of the USSR Academy of Medical ScienceUSSRMoscowRussia

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