Abstract
There are several approaches to the study of endogenous prostaglandins (PGs) in man. One is to measure a major metabolite in urine and estimate changes in body turnover under different circumstances (FitzGerald et al., 1981). This technique has the advantage of not requiring blood sampling and of giving information related to synthesis integrated over several hours. A disadvantage is that the site of production of the PG is unknown. Another approach is the use of inhibitors of PG synthetic enzymes or receptors. The main problem here is the lack of sufficiently specific compounds. When more specific inhibitors and antagonists become available many outstanding questions may be answered.
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Dollery, C.T., Barrow, S.E., Heavey, D., Ritter, J.M. (1984). Vascular and platelet effects of prostacyclin and prostaglandin D2 in man. In: Paton, W., Mitchell, J., Turner, P., Padgham, C., Ashcroft, E. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17615-1_1
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DOI: https://doi.org/10.1007/978-1-349-17615-1_1
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