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β-Lactam antibiotics with novel nuclei

  • F. O’Grady

Abstract

Since the isolation of the penicillin nucleus a huge number of semisynthetic penams and cephems have been generated by manipulation of the side chain at the 6 position of 6 amino penicillanic acid and at the 7 and 3 positions of 7 amino-cephalosporanic acid. The objectives of this manipulation have been to secure improvements over the parent compounds in four properties: (1) degree of intrinsic antibacterial activity; (2) extension of antibacterial range to include organisms resistant to the parent compound — an objective that has centred to a substantial extent on Pseudomonas aeruginosa, but has extended to include other naturally resistant Gram-negative rods such as Enterobacter, Serratia, indole-positive Proteus and anaerobic bacteria; (3) stability to a wide range of β-lactamases, the major cause of resistance in an increasing variety of organisms to earlier β-lactams; and (4) improvement in pharmacokinetic behaviour.

Keywords

Antibacterial Activity Clavulanic Acid Neisseria Gonorrhoeae Lactam Antibiotic Penicillanic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • F. O’Grady
    • 1
  1. 1.Department of Microbiology and PHLS LaboratoryQueen’s Medical CentreNottinghamUK

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