Mechanisms of desensitization of β-adrenergic receptors

  • J. P. Perkins
  • T. K. Harden


For the past several years we and our colleagues have been involved in a study of catecholamine-induced desensitization of the β-adrenergic receptor (βAR)-linked adenylate cyclase system. There appears to be a number of processes utilized by cells to reduce responsiveness to catecholamines (see Lefkowitz et al., 1980; Perkins et al., 1982; Harden, 1983; Hertel & Perkins, 1985 for recent reviews). Our studies have focused on a desensitization process that is βAR-specific, that is, it results in changes in the system that eliminate responsiveness only to catecholamines.


Adenylate Cyclase Adrenergic Receptor Adenylate Cyclase Activity Adenylate Cyclase System Frog Erythrocyte 
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© Macmillan Publishers Limited 1984

Authors and Affiliations

  • J. P. Perkins
    • 1
  • T. K. Harden
  1. 1.Department of PharmacologyUniversity of North Carolina at Chapel HillUSA

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