Axonal transport of receptors

  • M. A. Zarbin
  • M. J. Kuhar


There are several aspects to the study of the life cycle of a receptor molecule. These include its identification, synthesis, transport, insertion into membranes, function, inactivation, turnover, and degradation. Because of the dramatic successes in the past ten to fifteen years in identifying receptors, many of the other aspects can be studied. A main interest of our laboratory over the past several years has been the axonal transport of drug and neurotransmitter receptors.


Sciatic Nerve Vagus Nerve Axonal Transport Nerve Trunk Opiate Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. ALONSO, F.G., CENA, V., GARCIA, A.F., KIRPEKAR, S.M. & SANCHEZ-GARCIA, P. (1982). Presence and axonal transport of cholinoceptor, but not adrenoceptor site on a cat noradrenergic neurone. J. Physiol., 333, 595–618.PubMedPubMedCentralCrossRefGoogle Scholar
  2. ATWEH, S.F. & KUHAR, M.J. (1977). Autoradiographic localization of opiate receptor in rat brain. I. Spinal cord and lower medulla. Brain Res., 124, 53–68.CrossRefGoogle Scholar
  3. ATWEH, S.F., MURRIN, L.C. & KUHAR, M.J. (1978). Presynaptic localization of opiate receptors in the vagal and accessory optic systems: an autoradiographic study. Neuropharmacology., 17, 65–71.PubMedCrossRefGoogle Scholar
  4. LADURON, P. (1980). Axoplasmic transport of muscarinic receptors. Nature, 286, 287–288.PubMedCrossRefGoogle Scholar
  5. LADURON, P.M. & JANSSEN, P.F.M. (1982). Axoplasmic transport and possible recycling of opiate receptors labelled with 3H-lofentanyl. Life Sci., 31, 457–462.PubMedCrossRefGoogle Scholar
  6. LEVIN, B.E. (1982). Presynaptic location and axonal transport of β1 adrenoreceptors in the rat brain. Science, 217, 555–557.PubMedCrossRefGoogle Scholar
  7. RODBELL, M. (1980). The role of hormone receptors and GTP regulatory proteins in membrane transduction. Nature, 284, 17–22.PubMedCrossRefGoogle Scholar
  8. WAMSLEY, J.K. (1983). Muscarinic cholinergic receptors undergo axonal transport in the brain. Eur. J. Pharmac., 86, 309–310.CrossRefGoogle Scholar
  9. YOUNG, III, W.S. & KUHAR, M.J. (1979). A new method for receptor autoradiography: 3H-opioid receptor labelling in mounted tissue sections. Brain Res., 179, 255–270.PubMedCrossRefGoogle Scholar
  10. YOUNG, III, W.S., WAMSLEY, J.K., ZARBIN, M.A. & KUHAR, M.J. (1980). Opioid receptors undergo axonal flow. Science, 210, 76–78.PubMedCrossRefGoogle Scholar
  11. ZARBIN, M.A., PALACIOS, J.M., WAMSLEY, J.K. & KUHAR, M.J. (1983). Axonal transport of β-adrenergic receptors. Mol. Pharmac., 24, 341–348.Google Scholar
  12. ZARBIN, M.A., WAMSLEY, J.K., INNIS, R.B. & KUHAR, M.J. (1981). CCK receptors: presence and axonal flow in the rat vagus nerve. Life Sci., 29, 697–705.PubMedCrossRefGoogle Scholar
  13. ZARBIN, M.A., WAMSLEY, J.K. & KUHAR, M.J. (1982). Axonal transport of muscarinic cholinergic receptors in rat vagus nerve. J. Neurosci., 2, 934–941.PubMedGoogle Scholar

Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • M. A. Zarbin
    • 1
  • M. J. Kuhar
  1. 1.Departments of Neuroscience, Pharmacology and Experimental Therapeutics, Psychiatry and Behavioral SciencesJohns Hopkins University School of MedicineBaltimoreUSA

Personalised recommendations