Enzymes as antiviral targets

  • Y. Cheng
  • K. Bastow
  • K. Frank
  • L. Nutter
  • J. -F. Chiou
  • S. Grill


Viruses as a whole are important pathogens. They have also been found to have a close association with certain human malignancies. Five types of herpesviruses were identified to be the causative agents in human diseases. They are herpes simplex virus (HSV) type 1, HSV-2, cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella zoster virus (VZV). These are DNA viruses capable of inducing biochemical changes in infected cells, which in most cases are triggered by virus induced or coded enzymes or proteins (Nahmias et al., 1981; Roizman, 1983). Several enzymes involved in DNA synthesis are known to be specified by some or all types of herpesvirus. A summary of these identified enzymes and the primary reactions they catalyze (Lemaster & Roizman, 1980; Blue & Stobbs, 1981; Cheng et al., 1982) is presented in Table 1.


Herpes Simplex Virus Herpes Simplex Virus Type Thymidine Kinase Varicella Zoster Virus Nucleoside Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • Y. Cheng
    • 1
  • K. Bastow
  • K. Frank
  • L. Nutter
  • J. -F. Chiou
  • S. Grill
  1. 1.Department of Pharmacology, School of MedicineUniversity of North Carolina at Chapel HillNorth CarolinaUSA

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