Abstract
Of all the receptor-coupled effector systems found in mammalian cells none has received more attention than the adenylate cyclase system (Lefkowitz et al., 1983; Smigel et al., 1984). Its ubiquity and the diversity of hormones and drugs which stimulate it has made it a premier model system for the study of the mechanisms whereby drugs and hormones activate their physiological effectors. Although numerous hormone receptors are coupled in a stimulatory or inhibitory fashion to the adenylate cyclase, to date only the β-adrenergic receptors, which respond to catecholamines such as adrenaline and noradrenaline, have been characterized in any significant detail. They are the only adenylate cyclase-coupled receptors which have been purified (Lefkowitz et al., 1983; Stiles et al., 1984a).
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Lefkowitz, R.J. et al. (1984). Purification, characterization and reconstitution of the adenylate cyclase-coupled β-adrenergic receptor. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17613-7_33
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DOI: https://doi.org/10.1007/978-1-349-17613-7_33
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