Abstract
Studies of the hormone-sensitive adenylate cyclase system have resulted in the discovery of two distinct guanine nucleotide-binding regulatory proteins, Gs and Gi (Ross & Gilman, 1980; Gilman, 1984; Smigel et al., 1984). Stimulation of adenylate cyclase by a wide variety of activators, including peptide hormones, biogenic amines, prostaglandins, cholera toxin, fluoride, and nonhydrolyzable GTP analogues (e.g. GTPĪ³S, Gpp(NH)p), is absolutely dependent on Gs. More recently, it has been demonstrated that hormonal inhibition of adenylate cyclase is mediated by a similar but distinct membrane-bound protein, Gi.
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References
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Kahn, R.A., Gilman, A.G. (1984). Guanine nucleotide-binding regulatory proteins: a family of membrane-bound transducers. In: Paton, W., Mitchell, J., Turner, P. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17613-7_32
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DOI: https://doi.org/10.1007/978-1-349-17613-7_32
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