Guanine nucleotide-binding regulatory proteins: a family of membrane-bound transducers

  • R. A. Kahn
  • A. G. Gilman


Studies of the hormone-sensitive adenylate cyclase system have resulted in the discovery of two distinct guanine nucleotide-binding regulatory proteins, Gs and Gi (Ross & Gilman, 1980; Gilman, 1984; Smigel et al., 1984). Stimulation of adenylate cyclase by a wide variety of activators, including peptide hormones, biogenic amines, prostaglandins, cholera toxin, fluoride, and nonhydrolyzable GTP analogues (e.g. GTPγS, Gpp(NH)p), is absolutely dependent on Gs. More recently, it has been demonstrated that hormonal inhibition of adenylate cyclase is mediated by a similar but distinct membrane-bound protein, Gi.


Adenylate Cyclase Cholera Toxin Guanine Nucleotide Adenylate Cyclase Activity Inhibit Adenylate Cyclase 
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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • R. A. Kahn
    • 1
  • A. G. Gilman
  1. 1.Department of PharmacologySouthwestern Graduate School, University of Texas Health Science Center at DallasDallasUSA

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