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The problems of extrapolating laboratory data to man in teratology

  • R. Jelínek

Abstract

Everybody knows what extrapolation is. However, it is useful from time to time to refresh one’s mind by reading a definition. ‘Extrapolation’ according to The Concise Oxford English Dictionary ‘is the calculation from known terms of a series of other terms which lie outside the range of the known terms’. Any extrapolation, therefore, should start with an inventory of the known terms. It may be relatively easy in exact sciences and wherever a higher degree of knowledge, that is natural law or at least theory, has been achieved. Although much has been written about extrapolation in teratology, no attempt has been made to argue on the basis offered by theory. Teratology remained for a long time an empirical branch of science working, in the field of extrapolation, with simple analogies. Instead of the usual compiling of dispersed data, this contribution aims to present a theoretical account of our chance to make extrapolations in teratology consequent upon the theory of morphogenetic systems. Before doing this, it is necessary to elucidate several terms and viewpoints.

Keywords

Chick Embryo Sensitive Period Palatal Shelf Actual Genotype Malformed Foetus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • R. Jelínek
    • 1
  1. 1.Institute of Experimental MedicineCzechoslovak Academy of SciencesPragueCzechoslovakia

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