Activity of single potassium channels recorded from single isolated visceral and vascular smooth muscle cells

  • T. B. Bolton
  • C. D. Benham
  • R. J. Lang
  • T. Takewaki


Relaxation of smooth muscle implies some existing tension. This is present presumably because the internal free ionised calcium concentration [Ca2+]; exceeds some threshold level causing activation of the myosin light chain kinase or leiotonin systems and actin-myosin interaction (Perry & Grand, 1979; Hartshorne, 1981). Relaxation of this existing tension may surely occur in a wide variety of ways; one obvious possibility is that [Ca2+]i is reduced and, probably after a slight delay, tension then declines.


Myosin Light Chain Kinase Membrane Patch Physiological Salt Solution Rabbit Jejunum Action Potential Discharge 
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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • T. B. Bolton
    • 1
  • C. D. Benham
  • R. J. Lang
  • T. Takewaki
  1. 1.Department of PharmacologySt George’s Hospital Medical SchoolLondonUK

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