Pharmacological approaches to neuropeptide function: substance P

  • L. L. Iversen


More than three dozen small peptides are known to occur in neurones in the mammalian nervous system (Iversen, 1983). Each of the neuropeptides may represent a novel chemical messenger, and as a class the neuropeptides offer considerable potential for the development of a new era of psychopharmacology. At the moment, however, our knowledge of peptide pharmacology remains rudimentary. The present review will summarize some recent developments in understanding the biochemical pharmacology of one neuropeptide, substance P (SP). The concepts and experimental approaches may prove applicable more generally to other neuropeptides.


Angiotensin Converting Enzyme Activity Mammalian Spinal Cord Mesocortical Dopamine Bovine Spinal Cord Mammalian Tachykinin 
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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • L. L. Iversen
    • 1
  1. 1.Merck Sharp & Dohme Research LaboratoriesNeuroscience Research CentreEssexUK

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