Relaxation of vascular smooth muscle by inhibitors of calmodulin and cyclic nucleotide dependent protein kinase
The free calcium ion concentration in cellular cytoplasm increases with excitation and with stimulation. These increases in ionized calcium may be the consequence of influxes of extracellular calcium, and/or release from the calcium storing organelles or binding sites in the cytoplasm. For a better understanding of the role of Ca2+ as a cellular control mediator and other aspects of its biochemistry, the activity of the cation in subcellular compartments has to be manipulated and transmembrane Ca2+ fluxes have to be altered, with minimal disturbance to other properties of the system.
KeywordsRenal Blood Flow Myosin Light Chain Kinase Entry Blocker Physiological Salt Solution Calcium Entry Blocker
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