Relaxation of vascular smooth muscle by inhibitors of calmodulin and cyclic nucleotide dependent protein kinase

  • H. Hidaka
  • T. Asano
  • M. Inagaki


The free calcium ion concentration in cellular cytoplasm increases with excitation and with stimulation. These increases in ionized calcium may be the consequence of influxes of extracellular calcium, and/or release from the calcium storing organelles or binding sites in the cytoplasm. For a better understanding of the role of Ca2+ as a cellular control mediator and other aspects of its biochemistry, the activity of the cation in subcellular compartments has to be manipulated and transmembrane Ca2+ fluxes have to be altered, with minimal disturbance to other properties of the system.


Renal Blood Flow Myosin Light Chain Kinase Entry Blocker Physiological Salt Solution Calcium Entry Blocker 
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© Macmillan Publishers Limited 1984

Authors and Affiliations

  • H. Hidaka
    • 1
  • T. Asano
  • M. Inagaki
  1. 1.Department of PharmacologyMie University School of MedicineEdobashiJapan

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