The relative importance of inositol 1,4,5-trisphosphate, 1,2-diacylglycerol and phosphatidic acid in mediating human platelet activation by thrombin

  • E. G. Lapetina
  • S. P. Watson


Thrombin-induced platelet activation can be correlated with formation of three potential bioactive agents (i.e. , second messengers), namely, inositol 1,4,5-trisphosphate, 1,2-diacylglycerol and phosphatidic acid. The present article reviews the relative importance of these three second messengers. It is suggested that both 1,2-diacylglycerol and phosphatidic acid may be of importance in activating protein kinase C in platelets, and that inositol 1,4,5-trisphosphate and possibly lysophosphatidic acid, may be of importance in mobilizing Ca++. It is concluded that thrombin-induced platelet activation occurs through the synergistic interaction of Ca++ and protein kinase C activation.


Human Platelet Phosphatidic Acid Pancreatic Acinar Cell Lysophosphatidic Acid Release Reaction 
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© Macmillan Publishers Limited 1984

Authors and Affiliations

  • E. G. Lapetina
    • 1
  • S. P. Watson
  1. 1.Department of Molecular BiologyThe Wellcome Research LaboratoriesUSA

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