Monobactams and other monocyclic β-lactams

  • D. P. Bonner
  • W. H. Koster
  • R. B. Sykes


Traditional approaches aimed at improving the in vitro and in vivo properties of β-lactam antibiotics have until recently focused on a bicyclic nucleus. This basic tenet that a fused ring system is necessary for meaningful antibacterial activity was formulated early in the development of penicillin and has generally held throughout the discovery and development of the cephalosporins, cephamycins and carbapenems. Constraints imposed by this doctrine have tended to direct structural alterations of the β-lactam antibiotics to peripheral changes on the bicyclic framework. The discovery of the monobactams (Sykes et al., 1981) and subsequent variation of the monocyclic β-lactam activating species (Cimarusti & Sykes, 1984) have provided a radical departure from this precept.


Unique Spectrum Lactam Antibiotic Inhibit Cell Wall Charles River Breeding Laboratory Fuse Ring System 
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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • D. P. Bonner
    • 1
  • W. H. Koster
  • R. B. Sykes
  1. 1.The Squibb Institute for Medical ResearchNew Jersey USA

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