Abstract
A knowledge of how antimicrobial drugs are biosynthesised is essential for the production and purification of such drugs and provides a means whereby new drugs can be synthesised chemically. All the major antibiotics in use today are produced by bacteria or fungi with the exception of small antibiotic molecules such as chloramphenicol which can be synthesised chemically. As can be seen from table 3.1, the major antibiotics are produced from a relatively few types of microorganism, the classification of which was dealt with in chapter 1.
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3.6 References and Further Reading
Abraham, E. P. (ed). (1974). Biosynthesis and Enzymatic Hydrolysis of Penicillins and Cephalosporins. University of Tokyo Press, Tokyo
Evans, R. M. (1965). The Chemistry of the Antibiotics used in Medicine. Pergamon, London
Gottlieb, D. and Shaw, P. D. (eds) (1967). Antibiotics, Vol. II, Biosynthesis. Springer-Verlag, New York
Hammond, S. M. (1977). Biological activity of polyene antibiotics. In Progress in Medicinal Chemistry (G. P. Ellis and G. B. West, eds). Elsevier, North-Holland, Amsterdam, pp. 105–7
Kanzaki, T. and Fujisawa, Y. (1976). Biosynthesis of cephalosporins. Adv. appl. Microbiol., 20, 159–201
Kleinkauf, H. and Gevers, W. Non-ribosomal polypeptide synthesis. The biosynthesis of a cyclic peptide antibiotic, gramicidin S. Cold Spring Harbor Symp. quant. Biol., 34, 805–13
Martin, J. F. (1977). Biosynthesis of polyene macrolide antibiotics. A. Rev. Microbiol., 31, 13–38
Snell, J. F. (ed.) (1966). Biosynthesis of Antibiotics. Academic Press, London
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© 1980 David Edwards
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Edwards, D. (1980). Biosynthesis of Antimicrobial Drugs. In: Antimicrobial Drug Action. Palgrave, London. https://doi.org/10.1007/978-1-349-16360-1_3
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DOI: https://doi.org/10.1007/978-1-349-16360-1_3
Publisher Name: Palgrave, London
Print ISBN: 978-0-333-23568-3
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