Abstract
It has been known since the earliest studies on the biosynthesis of proteins that the ribosomal particles are the sites of protein synthesis in the cell. These nucleoprotein particles, present in every cell which carries out protein synthesis, vary somewhat in size but are of basically similar structural build-up in different organisms and fulfil the same function. They bring together the different components of the translation system, in the correct spatial arrangement and in the right conformation required for the highly specific interactions between these components. They bring about the formation of peptide bonds between the amino acids which are specified in the message.
Preview
Unable to display preview. Download preview PDF.
References
Kurland, C. G. in Molecular Mechanisms of Protein Biosynthesis (eds Weissbach, H. and Pestka, S.) Academic Press, New York, 81 (1977).
Roberts, B. E. and Paterson, B. M. PNAS, 70, 2330 (1973).
Gross, K., Probst, E., Schaffner, W. and Birnstiel, M. Cell, 8, 455 (1973).
Strohman, R. C., Moss, P. S., Micou-Eastwood, J., Spector, D., Przybyla, A. and Paterson, B. Cell, 10, 265 (1977).
Heywood, S. M., Kennedy, D. S. and Bester, A. J. PNAS, 71, 2428 (1974).
Lane, C. D., Gregory, C. M. and Morel, C. Eur. J. Biochem., 34, 219 (1973).
Lodish, H. F. J. Mol. Biol., 50, 689 (1970); Nature, 226, 705 (1970).
Hall, N. D. and Arnstein, H. R. V. Biochem. Biophys. Res. Comm., 54, 1489 (1973).
Stöffler, G. and Wittmann, H. G. in Molecular Mechanisms of Protein Biosynthesis (eds Weissbach, H. and Pestka, S.) Academic Press, New York, 117, (1977).
Boublik, M. and Hellmann, W. PNAS, 75, 2829 (1978).
Brownlee, G. G., Sanger, F. and Barrell, B. G. Nature, 215, 735 (1967).
Erdmann, V. A. Nucl. Acids Res., 6, r29 (1979).
Ofengand, J. and Henes, C. J. Biol. Chem., 244, 6241 (1969).
Herr, W. and Noller, H. F. FEBS Lett., 53, 248 (1975).
Weidner, H., Yuan, R. and Crothers, D. M. Nature, 266, 193 (1977).
Erdmann, V. A. Progr. Nucl. Acid Res. Mol. Biol., 18, 45 (1976).
Fox, G. E. and Woese, C. R. Nature, 256, 505 (1975).
Nishikawa, K. and Takemura, S. FEBS Lett., 40, 106 (1974).
Bear, D. G., Schleich, T., Noller, H. F. and Garrett, R. A. Nucl. Acid Res., 4, 2511 (1977).
Branlant, C., Sri Widada, J., Krol, A. and Ebel, J. P. Eur. J. Biochem., 74, 155 (1977).
Van Duin, J., Kurland, C. G., Dondon, J., Grunberg-Manago, M., Branlant, C. and Ebel, J. P. FEBS Lett., 62, 111 (1976).
Sonenberg, N., Wilchek, M. and Zamir, A. Eur. J. Biochem., 77, 217 (1977).
Carbon, P., Ehresmann, C. and Ebel, J. P. FEBS Lett., 94, 152 (1978).
Bowman, C. M., Dahlberg, J. E., Ikemura, T., Konisky, J. and Nomura, M. PNAS, 68, 964 (1971).
Shine, J. and Dalgarno, L. Nature, 254, 34 (1975).
Sprague, K. U., Steitz, J. A., Greney, R. M. and Stocking, C. E. Nature, 267, 462 (1977).
Steitz, J. A., Wahba, A. J., Laughrea, M. and Moore, P. B. Nucl. Acids Res., 4, 1 (1977).
Dahlberg, A. E. and Dahlberg, J. E. PNAS, 72, 2940 (1975).
Steitz, J. A. personal communication.
Baan, R. A., Hilbers, C. W., Van Charldorp, R., Van Leerdam, E., Van Knippenberg, P. H. and Bosch, L. PNAS, 74, 1028 (1977).
Cox, R. A. Progr. Biophys. Molec. Biol., 32, 193 (1977).
Kurland, C. G. in Ribosomes (eds Nomura, M., Tissieres, S. and Lengyel, P.) Cold Spring Harbor Laboratories, New York, 309 (1974).
Brimacombe, R. in Relations between Structure and Function in the Prokaryotic Cell (eds Stanier, R. Y., Rogers, H. J. and Ward, J. B.) Cambridge University Press, 1 (1978).
Hochkeppel, H. K. and Craven, G. R. J. Mol. Biol., 113, 623 (1977).
Luoma, G. A. and Marshall, A. G. J. Mol. Biol., 125, 95 (1978).
Wrede, P. and Erdmann, V. A. PNAS, 74, 2706 (1977).
Jaskunas, S. R., Nomura, M. and Davies, J. in Ribosomes (eds Nomura, M., Tissieres, S. and Lengyel, P.) Cold Spring Harbor Laboratories, New York, 333 (1974).
Reeder, R. H. in Ribosomes (eds Nomura, M., Tissieres, S. and Lengyel, P.) Cold Spring Harbor Laboratories, New York, 489 (1974).
Walker, T. A. and Pace, N. R. Nucl. Acids Res., 4, 595 (1977).
Hagenbiichle, O., Santer, M. and Steitz, J. A. Cell, 13, 551 (1978).
Subramanian, A. R., Haase, C. and Giesen, M. Eur. J. Biochem., 67, 591 (1976).
Martini, O. H. W. and Gould, H. J. Mol. Gen. Genet., 142, 317 (1975).
Kaltschmidt, E. and Wittmann, H. G. PNAS, 67, 1276 (1970).
Hardy, S. J. S. Mol. Gen. Genet., 140, 253 (1975).
Subramanian, A. R. J. Mol. Biol., 95, 1 (1975).
Isono, K. and Isono, S. PNAS, 73, 767 (1976).
Traub, P. and Nomura, M. PNAS, 59, 777 (1968).
Nomura, M. and Erdmann, V. A. Nature, 228, 744 (1970).
Dohme, F. and Nierhaus, K. H. J. Mol. Biol., 107, 585 (1976).
Moore, V. G., Atchison, R. E., Thomas, G., Moran, M. and Noller, H. F. PNAS, 72, 844 (1975).
Nierhaus, K. H. and Montejo, V. PNAS, 70, 1931 (1973).
Pongs, O., Stöffler, G. and Bald, R. W. Nucl. Acids Res., 3, 635 (1976).
Eliat, D., Pellegrini, M., Oen, H., Lapidot, Y. and Cantor, C. R. J. Mol. Biol., 88, 831 (1974).
Tate, W. P., Caskey, C. T. and Stöffler, G. J. Mol. Biol., 93, 375 (1975).
Van Dieijn, G., Van der Laken, C. J., Van Knippenberg, P. H. and Van Duin, J. J. Mol. Biol., 93, 351 (1975).
Szer, W., Hermoso, J. M. and Leffler, S. PNAS, 72, 2325 (1975).
Bosch, L. in Proceedings of the 10th FEBS Meeting (eds Chapeville, F. and Grunberg-Manago, M.) North Holland/American Elsevier, New York, 275 (1975).
Isono, S. and Isono, K. Eur. J. Biochem., 56, 15 (1975).
Czernilofsky, A. P., Kurland, C. G. and Stöffler, G. FEBS Lett., 58, 281 (1975).
Bear, D. G., Ng, Ray, Van Derveer, D., Johnson, N. P., Thomas, G., Schleich, T. and Noller, H. F. PNAS, 73, 1824 (1976).
Szer, W., Hermoso, J. M. and Boublik, M. Biochem. Biophys. Res. Comm., 70, 957 (1976).
Thomas, J. O., Kolb, A. and Szer, W. J. Mol. Biol., 123, 163 (1978).
Kolb, A., Hermoso, J. M., Thomas, J. O. and Szer, W. PNAS, 74, 2379 (1977).
Carmichael, G. G., Weber, K., Niveleau, A. and Wahba, A. J. J. Biol. Chem., 250, 3607 (1975).
Senear, A. W. and Steitz, J. A. J. Biol. Chem., 251, 1902 (1975).
Gorini, L. Nature NB 234 261 (1971).
Mizushima, S. and Nomura, M. Nature, 226, 1214 (1970).
Nierhaus, K. H. and Dohme, F. PNAS, 71, 4713 (1974).
Spillman, S., Dohme, F. and Nierhaus, K. H. J. Mol. Biol., 115, 513 (1977).
Hochkeppel, H.-K., Spicer, E. and Craven, G. R. J. Mol. Biol., 101, 155 (1976).
Bear, D. G., Schleich, T., Noller, H. F. and Garrett, R. A. Nucl. Acids Res., 4, 2511 (1977).
Brimacombe, R., Nierhaus, K. H., Erdmann, V. A. and Wittmann, H. G. Progr. Nucl. Acid Res. Mol. Biol., 18, 1 (1976).
Ungewickel, E., Garrett, R., Ehresmann, C., Stiegler, P. and Fellner, P. Eur. J. Biochem., 51, 165 (1975).
Ehresmann, B., Backendorf, C., Ehresmann, C. and Ebel, J. P. FEBS Lett., 78, 261 (1977).
Sloof, P., Garrett, R. A. and Nanninga, N. Mol. Gen. Genet., 147, 129 (1976).
Dennis, P. P. and Nomura, M. J. Mol. Biol., 97, 61 (1975).
Jaskunas, S. R., Lindahl, L. and Nomura, M. Nature, 256, 183 (1975).
Nomura, M. Cell, 9, 633 (1977).
Yamamoto, M. and Nomura, M. J. Bacteriol., 137, 584 (1979);PNAS, 75, 3891 (1978).
Lund, E., Dahlberg, J. E., Jaskunas, S. R., Dennis, P. P. and Nomura, M. Cell., 7, 165 (1976).
Morgan, E. A., Ikemura, T., Lindahl, L., Fallon, A. M. and Nomura, M. Cell., 13, 335 (1978).
Gorenstein, C. and Warner, J. R. PNAS, 73, 1547 (1976).
Warner, J. R. and Gorenstein, C. Cell, 11, 201 (1977).
Blatti, S. P., Ingles, C. J., Lindell, T. J., Morris, P. W., Weaver, R. F., Weinberg, F. and Rutter, W. J. Cold Spring Harbor Symp., 35, 649 (1970).
Weinmann, R. and Roeder, R. G. PNAS, 71, 1790 (1974).
Kyriakopoulos, A. and Subramanian, A. R. Biochem. Biophys. Acta, 474, 308 (1977).
Dahlberg, J. E., Kintner, C. and Lund, E. PNAS, 75, 1071 (1978).
Hochkeppel, H. K. and Gordon, J. Nature, 273, 560 (1978).
Cole, M. D., Beer, M., Koller, T., Strycharz, W. A. and Nomura, M. PNAS, 75, 270 (1978).
Post, L. E., Arfsten, A. E., Reusser, F. and Nomura, M. Cell, 15, 215 (1978).
Author information
Authors and Affiliations
Copyright information
© 1980 Maria Szekely
About this chapter
Cite this chapter
Szekely, M. (1980). The Site of Protein Synthesis: The Ribosome. In: From DNA to Protein. Palgrave, London. https://doi.org/10.1007/978-1-349-16264-2_7
Download citation
DOI: https://doi.org/10.1007/978-1-349-16264-2_7
Publisher Name: Palgrave, London
Print ISBN: 978-0-333-21838-9
Online ISBN: 978-1-349-16264-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)