Advertisement

The Structure of Messenger RNA

  • Maria Szekely
Chapter

Abstract

Interest in the primary structure of mRNA dates back to the time when the messenger concept was first introduced by Jacob and Monod. Although their hypothesis was based rather on the functional requirement for a mediator between DNA and protein than on direct evidence for the existence of such a substance, it was strongly supported by the work of Volkin and Astrachan1, who characterised an RNA fraction which seemed to fit the above requirements. This RNA fraction, synthesised in E. coli cells after phage infection, was shown to have a base composition similar to that of DNA. This finding directed attention to the ‘rapidly labelled’ or ‘DNA-like’ RNA and encouraged further research2 into the characterisation of this RNA fraction.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Volkin, E. and Astrachan, L. Virology, 2, 149 (1956).CrossRefGoogle Scholar
  2. 2.
    Gros, F., Hiatt, H., Gilbert, W., Kurland, C. G. and Risebrough, R. W. Nature, 190, 581 (1961).CrossRefGoogle Scholar
  3. 3.
    Hall, B. D. and Spiegelmann, S. PNAS, 47, 137 (1961).CrossRefGoogle Scholar
  4. 4.
    Adams, J. M., Jeppesen, P. G. N., Sanger, F. and Barrell, B. G. Nature, 223, 1009 (1969).CrossRefGoogle Scholar
  5. 5.
    Steitz, J. A. Nature 224, 957 (1969).CrossRefGoogle Scholar
  6. 6.
    Sanger, F. Biochem. J., 124, 833 (1971).CrossRefGoogle Scholar
  7. 7.
    Billeter, M. A., Dahlberg, J. E., Goodman, H. M., Hindley, J. and Weissmann, C. Nature, 224, 1083 (1969).CrossRefGoogle Scholar
  8. 8.
    Min Jou, W., Haegeman, G., Ysebaert, M. and Fiers, W. Nature, 237, 82 (1972).CrossRefGoogle Scholar
  9. 9.
    Fiers, W. et al. Nature, 256, 273 (1975).CrossRefGoogle Scholar
  10. 10.
    Fiers, W. et al. Nature, 260, 500 (1976).CrossRefGoogle Scholar
  11. 11.
    Sanger, F., Air, G. M., Barrell, B. G., Brown, N. L., Coulson, A. R., Fiddes, J. C., Hutchison, C. A. III, Slocombe, P. M. and Smith, M. Nature, 265, 687 (1977).CrossRefGoogle Scholar
  12. 12.
    Ravetch, J. V., Model, P. and Robertson, H. D. Nature, 265, 698 (1977).CrossRefGoogle Scholar
  13. 13.
    Squires, C., Lee, F., Bertrand, K., Squires, C. L., Bronson, M. J. and Yanofsky, C. J. Mol. Biol., 103, 351 (1976).CrossRefGoogle Scholar
  14. Bronson, M. J., Squires, C. and Yanofsky, C. PNAS, 70, 2335 (1973).CrossRefGoogle Scholar
  15. 14.
    Maizels, N. M. PNAS, 70, 3585 (1973).CrossRefGoogle Scholar
  16. 15.
    Musso, R. E., de Crombrugghe, B., Pastan, I., Sklar, J., Yot, P. and Weissman, S. PNAS, 71, 4940 (1974).CrossRefGoogle Scholar
  17. Sklar, J., Weissman, S., Musso, R. E., Di Lauro, R. and de Crombrugghe, B. J. Biol. Chem., 252, 3538 (1977).Google Scholar
  18. 16.
    Weber, K. Biochemistry, 6, 3144 (1967).CrossRefGoogle Scholar
  19. 17.
    Yudelevich, A. J. Mol. Biol., 60, 21 (1971).CrossRefGoogle Scholar
  20. Scherberg, N. H. and Weiss, S. B. PNAS, 67, 1164 (1970).CrossRefGoogle Scholar
  21. 18.
    Garel, J. P., Hentzen, D. and Daillie, J. FEBS Lett., 39, 359 (1974).CrossRefGoogle Scholar
  22. Garel, J. P. J. Theor. Biol., 43, 225 (1974).CrossRefGoogle Scholar
  23. Smith, D. W. E. Science, 190, 529 (1975).CrossRefGoogle Scholar
  24. 19.
    Platt, T. and Yanofsky, C. PNAS, 72, 2399 (1975).CrossRefGoogle Scholar
  25. 20.
    Contreras, R., Rogiers, R., Van der Voorde, A. and Fiers, W. Cell, 12, 529 (1977).CrossRefGoogle Scholar
  26. 21.
    Shine, J. and Dalgarno, L. Nature, 254, 34 (1975).CrossRefGoogle Scholar
  27. 22.
    Steitz, J. A. and Jakes, K. PNAS, 72, 4734 (1975).CrossRefGoogle Scholar
  28. 23.
    Sprague, K. U., Steitz, J. A., Grenley, R. M. and Stocking, C. E. Nature, 267, 462 (1977).CrossRefGoogle Scholar
  29. 24.
    Moore, C. M., Fanon, F., Bohnert, D. and Weissmann, C. Nature NB, 234, 204 (1971).Google Scholar
  30. Weiner, A. M. and Weber, K. Nature NB, 234, 206 (1971).Google Scholar
  31. aWalz, A., Pirrotta, V. and Ineichen, K. Nature, 262, 665 (1976).CrossRefGoogle Scholar
  32. 25.
    Lee, F. and Yanofsky, C. PNAS, 74, 4365 (1977).CrossRefGoogle Scholar
  33. 26.
    Bertrand, K., Korn, L., Lee, F., Platt, T., Squires, C. L., Squires, C. and Yanofsky, C. Science, 189, 22 (1975).CrossRefGoogle Scholar
  34. 26a.
    Di Nocera, P. P., Blasi, F., Di Lauro, R., Frunzio, R. and Bruni, C. B. PNAS, 75, 4276 (1978).CrossRefGoogle Scholar
  35. Barnes, W. M. PNAS, 75, 4281 (1978).CrossRefGoogle Scholar
  36. Zurawski, G., Brown, K., Killingly, D. and Yanofsky, C. PNAS, 75, 4271 (1978).CrossRefGoogle Scholar
  37. Lee, F., Bertrand, K., Bennett, G. and Yanofsky, C. J. Mol. Biol., 121, 193 (1978).CrossRefGoogle Scholar
  38. 27.
    Aviv, H. and Leder, P. PNAS, 69, 1408 (1972).CrossRefGoogle Scholar
  39. 28.
    Brownlee, G. G., Cartwright, E. M., Cowan, N. J., Jarvis, J. M. and Milstein, C. Nature NB, 244, 2 (1973).CrossRefGoogle Scholar
  40. 29.
    Schimke, R. T., Palacios, R., Sullivan, D., Kiely, M. L., Gonzales, C. and Taylor, J. M. Methods in Enzymology, 30F, 631 (1974).CrossRefGoogle Scholar
  41. 30.
    Proudfoot, N. J. Cell, 10, 559 (1977).CrossRefGoogle Scholar
  42. Efstratiadis, A., Kafatos, F. C. and Maniatis, T. Cell, 10, 571 (1977).CrossRefGoogle Scholar
  43. 31.
    Baralle, F. E. Cell, 12, 1085 (1977).CrossRefGoogle Scholar
  44. 32.
    Hsu, M. and Ford, J. PNAS, 74, 4982 (1977).CrossRefGoogle Scholar
  45. Fiers, W. et al. Nature, 273, 113 (1978).CrossRefGoogle Scholar
  46. Klessig, D. F. Cell, 12, 9 (1977).CrossRefGoogle Scholar
  47. Chow, L. T. and Broker, T. R. Cell, 15, 497 (1978).CrossRefGoogle Scholar
  48. 33.
    Legon, S. J. Mol. Biol., 106, 37 (1976).CrossRefGoogle Scholar
  49. 34.
    Baralle, F. E. Cell, 10, 549 (1977).CrossRefGoogle Scholar
  50. 35.
    Hagenbuchle, O., Santer, M. and Steitz, J. A. Cell, 13, 551 (1978).CrossRefGoogle Scholar
  51. 36.
    Kozak, M. Nature, 269, 390 (1977).CrossRefGoogle Scholar
  52. 37.
    Huez, G. et al. PNAS, 71, 3134 (1974).CrossRefGoogle Scholar
  53. Marbaix, G. et al. PNAS, 72, 3065 (1975).CrossRefGoogle Scholar
  54. 38.
    Brawerman, G. Progr. Nucl. Acid Res. Mol. Biol., 17, 117 (1976).CrossRefGoogle Scholar
  55. 39.
    Rottman, F., Shatkin, A. J. and Perry, R. P. Cell, 3, 197 (1974).CrossRefGoogle Scholar
  56. Abraham, G., Rhodes, D. P. and Banerjee, A. K. Nature, 255, 37 (1975).CrossRefGoogle Scholar
  57. 40.
    Adams, J. M. and Cory, S. Nature, 255, 28 (1975).CrossRefGoogle Scholar
  58. Mutukrishnan, S., Both, G. W., Furuichi, Y. and Shatkin, A. J. Nature, 255, 33 (1975).CrossRefGoogle Scholar
  59. 41.
    Shatkin, A. J. Cell, 9, 645 (1976).CrossRefGoogle Scholar
  60. 42.
    Zan-Kowalczewska, M., Bretner, M., Sierakowska, H.,Szczesna, E., Filipowicz, W. and Shatkin, A. J. Nucl. Acids Res., 4, 3065 (1977).CrossRefGoogle Scholar
  61. 43.
    Jacobson, A. B. and Spahr, P. F. J. Mol. Biol., 115, 279 (1977).CrossRefGoogle Scholar
  62. 44.
    Isenberg, H., Cotter, R. I. and Gratzer, W. B. Biochim. Biophys. Acta, 232, 184 (1971).CrossRefGoogle Scholar
  63. 45.
    Tinoco, T., Borer, P. N., Dengler, B., Levine, M. D., Ohlenback, O. C., Crothers, D. M. and Gralla, J. Nature NB, 246, 40 (1973).Google Scholar
  64. 46.
    Lodish, H. F. and Robertson, H. D. Cold Spring Harbor Symp., 34, 655 (1969).CrossRefGoogle Scholar
  65. Lodish, H. F. J. Mol. Biol., 50, 689 (1970).CrossRefGoogle Scholar
  66. 47.
    Steitz, J. A. PNAS, 70, 2605 (1973).CrossRefGoogle Scholar
  67. 48.
    Lodish, H. F. in RNA phages (ed. Zinder, N. D.) Cold Spring Harbor Laboratory, New York, 301 (1975).Google Scholar
  68. 49.
    vanDieijn, G., Van Knippenberg, P. H. and Van Duin, J. Eur. J. Biochem., 64, 511 (1976).CrossRefGoogle Scholar
  69. 50.
    Bear, D. G., Ng, Ray, Van Derveer, D., Johnson, N. P., Thomas, G., Schleich, T. and Noller, H. F. PNAS, 73, 1824 (1976).CrossRefGoogle Scholar
  70. Szer, W., Hermoso, J. M. and Boublik, M. Biochem. Biophys. Res. Comm., 70, 957 (1976).CrossRefGoogle Scholar
  71. 51.
    Heindell, H. C., Liu, A., Paddock, G. V., Studnicka, G. M. and Salser, W. A. Cell, 15, 43 (1978).CrossRefGoogle Scholar
  72. 52.
    McReynolds, L. et al. Nature, 273, 723 (1978).CrossRefGoogle Scholar
  73. 53.
    Baralle, F. E. and Brownlee, G. G. Nature, 274, 84 (1978).CrossRefGoogle Scholar
  74. 54.
    Kozak, M. and Shatkin, A. J. Cell, 13, 201 (1978).CrossRefGoogle Scholar
  75. 55.
    Hamlyn, P., Brownlee, G. G., Cheng, C., Gait, M. J. and Milstein, C. Cell, 15, 1067 (1978).CrossRefGoogle Scholar
  76. 56.
    Ghosh, P. K., Reddy, V. B., Swinscoe, J., Choudary, P. V., Lebowitz, P. and Weissman, S. M. J. Biol. Chem., 253, 3643 (1978).Google Scholar
  77. Bina-Stein, M., Thoren, M., Salzman, N. and Thompson, J. A. PNAS, 76, 731 (1979).CrossRefGoogle Scholar
  78. 57.
    Kozak, M. and Shatkin, A. J. J. Mol. Biol., 112, 75 (1977).CrossRefGoogle Scholar

Copyright information

© Maria Szekely 1980

Authors and Affiliations

  • Maria Szekely
    • 1
  1. 1.Department of BiochemistryImperial CollegeLondonUK

Personalised recommendations