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DNA Topoisomerases

  • Raymond K. Ralph
  • Warren Judd
  • Yves Pommier
  • Kurt W. Kohn
Chapter
Part of the Topics in Molecular and Structural Biology book series (TMSB)

Abstract

The simple elegance of the antiparallel, plectonemic DNA double helix revealed by Watson, Crick and Wilkins gave substance to the concept of DNA as a repository of genetic information and a rationale for its replication (Watson and Crick, 1953). Subsequently the complexity of chromosomes has been slowly revealed (Gasser et al., 1989; Filipski et al., 1990), bringing with it the realization that simple models for DNA replication must be modified to explain the replication and resolution of knotted DNA, concatemeric DNA, radial looped DNA, nucleosome-coiled DNA or other phenomena such as DNA replication from multiple origins in eukaryotic cells (Hamlin et al., 1991). In addition, the progression of RNA or DNA polymerase produces topological effects on DNA templates which, if left unresolved, inhibit RNA and DNA synthesis (Brill et al., 1987; Uemura et al., 1987; Yamagishi and Nomura, 1988). The discovery of topoisomerases, enzymes that can resolve topological constraints in DNA, gave a clue to the mechanism(s) used by cells to overcome some of the problems resulting from DNA twisting (Vosberg, 1985; Wang, 1985). As their functions are revealed, these apparently magical enzymes can be seen as central to most of the events involving DNA, gene expression and growth of cells. Consequently, they are good potential targets for anticancer drugs.

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© The contributors 1994

Authors and Affiliations

  • Raymond K. Ralph
  • Warren Judd
  • Yves Pommier
  • Kurt W. Kohn

There are no affiliations available

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