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Galanin/5-HT interactions in the rat central nervous system. Relevance for depression

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Galanin

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

Abstract

During recent years we have obtained evidence for the existence of galanin (GAL)/5-hydroxytryptamine (5-HT) interactions at the pre-and postsynaptic level in the rat central nervous system (CNS). The main basis of these interactions appear to be bidirectional intramembrane interactions between GAL and 5-HT1A receptors (Fuxe et al., 1988a, 1990) which represents a way to increase plasticity of 5-HT neurotransmission, since the 5-HT1A receptor appears to be selectively modulated by GAL (Fuxe et al, 1988a). Recent work by Hedlund et al. (1990) indicates that in fact the 5-HT1A receptor subtype is regulated by an intramembrane feedback loop involving the high affinity GAL receptor.

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Authors
  1. K. Fuxe
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  2. P. Hedlund
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  3. G. von Euler
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  4. K. Lundgren
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  5. M. Martire
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  6. S. O. Ögren
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  7. P. Eneroth
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  8. L. F. Agnati
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Editor information

Editors and Affiliations

  1. Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden

    Tomas Hökfelt

  2. Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden

    Tamas Bartfai

  3. Laboratory of Clinical Science, NIMH, Bethesda, USA

    David Jacobowitz

  4. Wenner-Gren Center Foundation, Stockholm, Sweden

    David Ottoson

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© 1991 The Wenner-Gren Center

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Fuxe, K. et al. (1991). Galanin/5-HT interactions in the rat central nervous system. Relevance for depression. In: Hökfelt, T., Bartfai, T., Jacobowitz, D., Ottoson, D. (eds) Galanin. Wenner-Gren Center International Symposium Series. Palgrave, London. https://doi.org/10.1007/978-1-349-12664-4_16

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  • DOI: https://doi.org/10.1007/978-1-349-12664-4_16

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-12666-8

  • Online ISBN: 978-1-349-12664-4

  • eBook Packages: EngineeringEngineering (R0)

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