Relevance of surfactant inactivation by anti-surfactant antibodies to the evaluation of therapies for neonatal RDS
Infantile respiratory distress syndrome (IRDS) develops because immature lungs in preterm infants may not synthesize sufficient surfactant to maintain low pulmonary alveolar surface tension . The course of IRDS is characterized by atelectasis, poor arterial oxygenation and end expiratory collapse of airways. Complications of IRDS include both pulmonary and neurological impairment. It is thus an important cause of morbidity and mortality in the neonatal period, especially for preterm infants.
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