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The Surfactant System of the Lung pp 28–33Cite as

Biological approaches to the prevention of RDS

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Abstract

The recognition that fetal lung maturation is dependent upon epithelial-mesenchymal interactions has led to understanding of the mechanism by which glucocorticoids accelerate fetal lung maturation. It is likely that deeper understanding of these phenomena will lead to new preventive and therapeutic approaches to respiratory distress syndrome (RDS). Tissue interactions are classified as inductive (lead to expression of a different set of genes) or permissive (no change in the set of genes being expressed, but quantitative changes in some) [1]. The corresponding cellular responses are called commitment and progression. In fetal lung development, the first occur early in development while the latter are seen near term. An interposed set of tissue interactions are less clearly characterized and are referred to as transitional.

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References

  1. Saxen, L. Inductive tissue interactions. In: Lash, J. W. and Burger, M. M. eds. Cell and Tissue Interactions, New York: Raven Press, 1977; 1–10.

    Google Scholar 

  2. Bissell, M. J., Hall, H. G. and Parry, G. How does the extra-cellular matrix direct gene expression? J Theor Biol 1982; 99: 31–68.

    Article  Google Scholar 

  3. Grobstein, C. Mechanism of organogenetic tissue interaction. J Natl Cancer Inst Monogr 1967; 26: 279–99.

    Google Scholar 

  4. Karkinen-Jaakelannen, M., Saxen, L. and Weiss, L. Cell Interactions in Development, New York: Academic Press, 1977.

    Google Scholar 

  5. Lash, J. W. and Burger, M. M. Cell and Tissue Interactions, New York: Raven Press, 1977.

    Google Scholar 

  6. Lash, J. W. and Whittaker, J. R. Concepts of Development, Stamford, Conn.: Simauer Associates, 1974.

    Google Scholar 

  7. Poste, G. and Nicolson, G. L. Cell Surface Reviews, Amsterdam. North-Holland, 1977.

    Google Scholar 

  8. Wessels, N. K. Tissue Interactions and Development, Menlo Park, Ca.: Benjamin/Cummings, 1977.

    Google Scholar 

  9. Hilfer, S. R. Development of terminal buds in the fetal mouse lung. Scanning Electron Microsc 1983; 3: 1387–401.

    Google Scholar 

  10. Kratochwil, K. Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse. Dev Biol 1969; 20: 46–71.

    Article  Google Scholar 

  11. Lawson, K. A. Stage specificity in the mesenchyme requirement of rodent lung epithelium in vitro: a matter of growth control? J Embryol Exp Morphol 1983; 74: 183–206.

    Google Scholar 

  12. Taderera, J. V. Control of lung differentiation in vitro. Dev Biol 1967; 16: 489–512.

    Article  Google Scholar 

  13. Wessels, N. K. Mammalian lung development: interactions in formation and morphogenesis of tracheal buds. J Exp Zool 1970; 175: 445–60.

    Article  Google Scholar 

  14. Rudnick, D. Developmental capacities of the chick lung in chorioallantoic grafts. J Exp Zool 1933; 66: 125–53.

    Article  Google Scholar 

  15. Borghese, E., Alescio, T. and Cassini, A. Experiments on induction and effect of gamma radiation in mouse lung developing in vitro. In: Rose, G. G. ed. Cinemicrography in Cell Biology, New York: Academic Press, 1963; 201–26.

    Chapter  Google Scholar 

  16. Dameron, F. L’influence de divers mesenchymes sur la differentiation de l’epithelium pulmonaire de l’embryon de poulet en culture in vitro. J Embryol Exp Morphol 1961; 9: 628–33.

    Google Scholar 

  17. Sampaolo, G. and Sampaolo, L. Observations histologiques sur le poumon de foetus de Cobaye, cultive in vitro. CR Assoc Anat; 45: 707–14.

    Google Scholar 

  18. Mendelson, C. R., Johnston, J. M., MacDonald, P. C. and Snyder, J. M. Multihormonal regulation of surfactant synthesis by human fetal lung in vitro. J Clin Endocrinol Metab 1981; 53: 307–17.

    Article  Google Scholar 

  19. Gross, I. and Wilson, C. M. Fetal rat lung maturation: initiation and modulation. J Appl Physiol: Resp Environ Exerc Physiol 1983; 55: 1725–32.

    Google Scholar 

  20. Alescio, T. and Cassini, A. Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium. J Exp Zool 1962; 150: 83–94.

    Article  Google Scholar 

  21. Spooner, B. S. and Wessels, N. K. Mammalian lung development: interactions in primordium formation and bronchial morphogenesis. J Exp Zool 1970; 175: 445–54.

    Article  Google Scholar 

  22. Hilfer, S. R., Rayner, R. M. and Brown, J. W. Mesenchymal control of branching pattern in the fetal mouse lung. Tissue Cell 1985; 17: 523–38.

    Article  Google Scholar 

  23. Alescio, T. and Colombo Piperno, E. A quantitative assessment of mesenchymal contribution to epithelial growth rate in mouse embryonic lung developing in vitro. J Embryol Exp Morphol 1967; 17: 213–27.

    Google Scholar 

  24. Goldin, G. V. and Wessels, N. K. Mammalian lung development: the possible role of cell proliferation in the formation of supernumerary tracheal buds and in branching morphogenesis. J Exp Zool 1979; 208: 337–46.

    Article  Google Scholar 

  25. Avery, M. E. and Mead, J. Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 1959; 97: 517–23.

    Google Scholar 

  26. Farrell, P. M. and Wood, R. E. Epidemiology of hyaline membrane disease in the United States: analysis of national mortality statistics. Pediatrics 1976; 58: 167–76.

    Google Scholar 

  27. Cheshire, L. B., Joyal, J. L., Peterson, R. D., Hester, R. B. Singh, G., Katyal, S. L. and Funkhouser, J. D. Isolation and examination of putative type II pneumocyte precursors. Pediatr Res 1987; 21: 211A (Abstr).

    Article  Google Scholar 

  28. Funkhouser, J. D., Cheshire, L. B., Ferrara, T. B. and Peterson, R. D. A. Monoclonal antibody identification of a type II alveolar epithelial cell antigen and expression of the antigen during lung development. Dev Biol 1987; 119: 190–8.

    Article  Google Scholar 

  29. Otto-Verberne, C. J. M. and Ten Have-Opbroek, A. A. W. Development of the pulmonary acinus in fetal rat lung: a study based on antiserum recognizing surfactant-associated proteins. Anat Embryol 1987; 175: 365–73.

    Article  Google Scholar 

  30. Ten Have-Opbroeck, A. A. W. The development of the lung in mammals: an analysis of concepts and findings. Am J Anat 1981; 162: 201–19.

    Article  Google Scholar 

  31. Kusakabe, M., Smith, B. T. and Post, M. Mesenchymal induction of surfactant protein expression in rat lung epithelium. Pediatr Res 1988; 23: 246A (Abstr).

    Google Scholar 

  32. Beer, D. G., Butley, M. S., Cunha, G. R. and Malkinson, A. M. Autoradiographic localization of specific (3H)dexamethasone binding in fetal lung. Dev Biol 1984; 105: 351–64.

    Article  Google Scholar 

  33. Sweezey, N. B., Buch, S. J., Rae, S., Mawdsley, C. and Post, M. Glucocorticoid receptor and surfactant protein expression in maturing rat lung. Pediatr Res 1989; 25: 61A (Abstr).

    Google Scholar 

  34. Smith, B. T. Prevention of hyaline membrane disease: an attempt to mimic a physiologic process. In: Moss, A. ed. Pediatrics Update, New York: Elsevier North-Holland, 1979; 151–67.

    Google Scholar 

  35. Smith, B. T. Pulmonary surfactant during fetal development and neonatal adaptation: hormonal control. In: VanGolde, L. M. G. and Batenburg, J. J. eds. Pulmonary Surfactant, Amsterdam: Elsevier, 1984; 357–81.

    Google Scholar 

  36. Smith, B. T. Lung maturation in the fetal rat: acceleration by the injection of fibroblast-pneumonocyte factor. Science 1979; 20: 1094–5.

    Article  Google Scholar 

  37. Post, M., Floros, J. and Smith, B. T Inhibition of lung maturation by monoclonal antibodies against fibroblast-pneumonocyte factor. Nature 1984; 308: 284–6.

    Article  Google Scholar 

  38. Floros, J., Post, M. and Smith, B. T. Glucocorticoids affect the synthesis of pulmonary fibroblast-pneumonocyte factor at a pretranslational level. J Biol Chem 1985; 260: 2265–7.

    Google Scholar 

  39. Floros, J., Post, M., Kay, R. M. and Smith, B. T. Molecular basis for a pulmonary mesenchymal-epithelial interaction. In: Progress in Developmental Biology, Part B, New York: Alan R. Liss, 1986; 333–7.

    Google Scholar 

  40. Post, M., Tseu, I. and Mawdsley, C. Mesenchymal influence on surfactant protein A synthesis. Pediatr Res 1989; 25: 58A (Abstr).

    Google Scholar 

  41. Post, M., Barsoumian, A. and Smith, B. T. The cellular mechanism of glucocorticoid acceleration of fetal lung maturation: fibroblast-pneumonocyte factor stimulates cholinephosphate cytidylyltransferase activity. J Biol Chem 1986; 261: 2179–85.

    Google Scholar 

  42. Post, M., Batenburg, J. J., Schuurmans, E. A. J. M. and Van Golde, L. M. G. The rate-limiting step in the biosynthesis of phosphatidylcholine by alveolar type II cells from adult rat lung. Biochim Biophys Acta 1982; 712: 390–4.

    Article  Google Scholar 

  43. Post, M., Batenburg, J. J., Smith, B. T. and Van Golde, L. M.G. Pool sizes of precursors for phosphatidylcholine formation in adult rat lung type II cells. Biochim Biophys Acta 1984; 795: 552–7.

    Article  Google Scholar 

  44. Post, M., Batenburg, J. J., Van Golde, L. M. G. and Smith, B. T. The rate-limiting reaction in phosphatidylcholine synthesis by alveolar type II cells isolated from fetal rat lung. Biochim Biophys Acta 1984; 795: 558–63.

    Article  Google Scholar 

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Authors
  1. Barry T. Smith
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Editor information

Editors and Affiliations

  1. Second Institute of Gynaecology and Obstetrics, University of La Sapienza, Rome, Italy

    E. V. Cosmi

  2. Institute of Gynaecology and Obstetrics, University of Perugia, Policlinico Monteluce, Perugia, Italy

    G. C. Di Renzo

  3. Second Institute of Gynaecology and Obstetrics, University of La Sapienza, Rome, Italy

    M. M. Anceschi

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© 1991 Macmillan Publishers Limited

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Smith, B.T. (1991). Biological approaches to the prevention of RDS. In: Cosmi, E.V., Di Renzo, G.C., Anceschi, M.M. (eds) The Surfactant System of the Lung. Palgrave, London. https://doi.org/10.1007/978-1-349-12553-1_5

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  • DOI: https://doi.org/10.1007/978-1-349-12553-1_5

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-12555-5

  • Online ISBN: 978-1-349-12553-1

  • eBook Packages: EngineeringEngineering (R0)

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