Skip to main content

Pathophysiology of adult RDS

  • Chapter
The Surfactant System of the Lung

Abstract

The adult respiratory distress syndrome (ARDS) represents a sequence of pathophysiological events that develop when there is a variety of frequently unrelated assaults to the lung, such as bacterial sepsis, aspiration, fat embolism, shock, drug injury and others [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bone, R. C. The adult respiratory distress syndrome: new trends. Medical Times 1987; 115: 33–41.

    Google Scholar 

  2. Giomarelli, P. P., Chiara, O., Borelli, E., Betti S., Volterrani, L., Lorenzini, L. and Grossi, A. Early diagnosis of adult respiratory distress syndrome: an experimental model of complement mediated pulmonary injury. J Thoracic Imaging 1988; 3 (3): 15–20.

    Article  Google Scholar 

  3. Pepe, P. E., Potkin, K. T. and Reus, D. H. Clinical predictors of the adult respiratory distress syndrome. Am J Surg 1982; 144: 124–30.

    Article  Google Scholar 

  4. Goris, R. J. A., Baekholtz, W. K. F., Van Bebber, I. P. T., Nuytink, J. K. S. and Schillings, P. H. M. Multiple organ failure and sepsis without bacteria: an experimental model. Arch Surg 1986; 121: 896–901.

    Article  Google Scholar 

  5. Chiara, O., Giomarelli, P. P. and Biagioli, B. Leukocytes-mediated pulmonary injury. Update Intens Care Emerg Med 1988; 125–30.

    Google Scholar 

  6. Chiara, O., Giomarelli, P. P. and Casini, A. Acute lung injury: role of lipid peroxidation. Update Intens Care Emerg Med 1989; 33–8.

    Google Scholar 

  7. Borrelli, E., Giomarelli, P. P., Chiara, O., Casini, A., Betti, S., Sabatini, L., Lorenzini, L. and Grossi, A. Liquid peroxidation and lung ultrastructural changes in an experimental model of leukocyte-mediated pulmonary injury. Lung 1990; 168: 35–42.

    Article  Google Scholar 

  8. Ohkawa, H., Ohishi, N. and Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction: Ann Biochem 1979; 95: 351–8.

    Article  Google Scholar 

  9. Burton, G. V., Webb, A. and Ingold, K. U. A mild rapid and efficient method of lipid extraction for use in determining vitamin E/lipid ratios. Lipids 1985; 20: 29–39.

    Article  Google Scholar 

  10. Jacobs, H. S., Craddock, P. R. Hammerschmidt, D. E. and Moldow, C. F. Complement induced granulocyte aggregation. An unsuspected mechanism of disease. New Engl J Med 1980; 302: 789–94.

    Google Scholar 

  11. Sibbald, W. J., Anderson, R. P. and Holliday, R. L. Pulmonary edema associated with the adult respiratory distress syndrome. Can Med Assoc J 1979; 120: 445.

    Google Scholar 

  12. Webster, R. O., Larsen, G. L. and Mitchell, B. C. Absence of inflammatory lung injury in rabbits challenged intravascularly with complement derived chemiotactic factors. Am Rev Resp Dis 1982; 125: 335–40.

    Google Scholar 

  13. Johnson, A., Cooper, J. A. and Malik, A. B. Effect of complement activation with cobra venom factor on pulmonary vascular permeability. J Appl Physiol 1986; 61: 2202–9.

    Google Scholar 

  14. Goris, R. J. A., Boekhorst, T. P. A. and Nuytink, J. K. S. Multiple organ failure: generalized autodestructive inflammation. Arch Surg 1985; 120: 1109–15.

    Article  Google Scholar 

  15. Stephenson, A. H., Lonigro, A. J., Hyers, T., Webster, R. O. and Fowler, A. A. Increased concentrations of leukotrienes in bronchoalveolar lavage fluid of patients with ARDS or at risk for ARDS. Am Rev Resp Dis 1988; 138: 714–19.

    Article  Google Scholar 

  16. Hammerschmidt, D. E., White, J. C. and Craddock, P. R. Corticosteroids inhibit complement-induced granulocyte aggregation. J Clin Invest 1979; 63: 798–803.

    Article  Google Scholar 

  17. Demling, R., Smith, M. and Gunther, R. Endotoxin-induced lung injury in anesthetized sheep: effects of methylprednisolone. Circulatory Shock 1981; 8: 351–7.

    Google Scholar 

  18. Sibbald, W., Anderson, R. and Reid, B. Alveolo-capillary permeability in human septic ARDS. Chest 1981; 79: 133–7.

    Article  Google Scholar 

  19. Bone, R. C., Fisher, C. J., Clemmer, T. P., Slotman, G. J. and Metz, C. A. Early methylprednisolone treatment for septic syndrome and the adult respiratory distress syndrome. Chest 1987; 92: 1032–6.

    Article  Google Scholar 

  20. Neugebauer, E., Schirren, J. and Lorenz, W. High-dose steroids and sepsis. New Engl J Med 1988; February 25: 314.

    Google Scholar 

  21. Hofman, S. I. High-dose steroids and sepsis. New Engl J Med 1988; February 25: 318.

    Google Scholar 

  22. Rinaldo, J. E. The prognosis of the adult respiratory distress syndrome: inappropriate pessimism? Chest 1986; 90: 470–1.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Copyright information

© 1991 Macmillan Publishers Limited

About this chapter

Cite this chapter

Grossi, A., Giomarelli, P. (1991). Pathophysiology of adult RDS. In: Cosmi, E.V., Di Renzo, G.C., Anceschi, M.M. (eds) The Surfactant System of the Lung. Palgrave, London. https://doi.org/10.1007/978-1-349-12553-1_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-12553-1_30

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-12555-5

  • Online ISBN: 978-1-349-12553-1

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics